DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXB and Gucy2e

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	XP_036012232.1	Gene:	Gucy2e / 14919	MGIID:	105123	Length:	1139	Species:	Mus musculus

Alignment Length:	302	Identity:	88/302 - (29%)
Similarity:	132/302 - (43%)	Gaps:	83/302 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   788 MMLLTMYA-------KERQSEFNTKINFKINQDLQGKQKAADITNKSIIILLTNILPSHVVEVYL 845
            :.:|..|:       :||..|..           |.|||    |::    |||.:||..|.|...
Mouse   855 LRMLEQYSSNLEDLIRERTEELE-----------QEKQK----TDR----LLTQMLPPSVAEALK 900

  Fly   846 DSVANHELYYENYKMVSVMFAMLINF----QMDLP--SLRVLNDIITEFDRLLNAYKEYYVVEKI 904
            ...:....|:|.   |::.|:.::.|    .|..|  .:.:|||:.|.||.::.|:..|    |:
Mouse   901 MGTSVEPEYFEE---VTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGAHDVY----KV 958

  Fly   905 KVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAFIMTTFALDLM 969
            :.:|..||.|.||     ..:.|.| ||:                      |:|    ..:||::
Mouse   959 ETIGDAYMVASGL-----PQRNGQR-HAA----------------------EIA----NMSLDIL 991

  Fly   970 RVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPG 1034
            ..:......:......|      |.||:.:|..:|||||.:.|.|.::|:.||.||||||||||.
Mouse   992 SAVGSFRMRHMPEVPVR------IRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPY 1050

  Fly  1035 HIHVTQETANIL----EQFDIMCMYRGMTFVKGRGEIPTYFV 1072
            .|||...|..||    :.|.:.|  ||.|.:||:|...||::
Mouse  1051 RIHVNMSTVRILRALDQGFQMEC--RGRTELKGKGIEDTYWL 1090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831
		CYCc	249..459	CDD:214485
		Nucleotidyl_cyc_III	298..484	CDD:299850
		CYCc	825..1047	CDD:214485	68/231 (29%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	71/228 (31%)
Gucy2e	XP_036012232.1	PBP1_sensory_GC_DEF-like	58..465	CDD:380594
		PK_GC-2D	570..845	CDD:270945
		HNOBA	<854..899	CDD:400168	17/62 (27%)
		CYCc	879..1070	CDD:214485	72/243 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900