Protein Alignment ACXB and Gucy2c

DIOPT Version :10

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: NP_001120790.1
• Gene: Gucy2c / 14917
• MGIID: 106903
• Length: 1072
• Species: Mus musculus
• Alignment Length: 1127
• Identity: 219/1127 - (19%)
• Similarity: 386/1127 - (34%)
• Gaps: 386/1127 - (34%)

  Fly   245 WLRQARQQ--------ESMLLDSILPPQIAKPIQQSIKE-----RIMLSETDSDRIVVNARRTEN 296
            |..|.||.        ..:::|:....:..:.::::::|     |..|.|.|.: :.|||
Mouse    22 WASQVRQNCRNGSYEISVLMMDNSAYKEPMQNLREAVEEGLDIVRKRLREADLN-VTVNA----- 80

  Fly   297 FMAIQIHPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCV 361
                      :.:|:|                 .::|.                   .|||....
Mouse    81 ----------TFIYSD-----------------GLIHK-------------------SGDCRSST 99

  Fly   362 AG----LGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGT---------LLAGVI 413
            ..    |.|...||......:|.|...:..::.....|:..|   :.:|:         .|..::
Mouse   100 CEGLDLLREITRDHKMGCALMGPSCTYSTFQMYLDTELNYPM---ISAGSYGLSCDYKETLTRIL 161

  Fly   414 GQA-KLQY---DIWGPDVDIANRLEATGKP-----GYVHVSGRTLSS----LNVAEYTVFPGTEV 465
            ..| ||.|   |.|..:       .|:.||     .||:.:|.....    ||..|..|...:||
Mouse   162 PPARKLMYFLVDFWKVN-------NASFKPFSWNSSYVYKNGSEPEDCFWYLNALEAGVSYFSEV 219

  Fly   466 AQSDPILQKQPMTTYLLTAAPSR-NSVRSVDAVHSYAEIDINALGASRKSPILRPTLMSDELREE 529
            .....:|::......:||....: |.:.......|:.::. ..|..:..:.::...|.|:...||
Mouse   220 LNFKDVLRRSEQFQEILTGHNRKSNVIVMCGTPESFYDVK-GDLQVAEDTVVILVDLFSNHYFEE 283

  Fly   530 FKKMPVGGFNI---RSPCCRDNSND---EKVNHGLGMFCVAFKDSSLEWSYLHK----------- 577
            ....|....|:   ..|..:..||.   |:.:.|...|.:|:.:.:|.:.::.:
Mouse   284 NTTAPEYMDNVLVLTLPSEQSTSNTSVAERFSSGRSDFSLAYLEGTLLFGHMLQTFLENGENVTG 348

  Fly   578 PDFILKYSVLLAWGIG--------------CCLIYIQIVNDKFTICVEC---------------- 612
            |.|...:..|...|..              ..|:|:.:...|:.:.::.
Mouse   349 PKFARAFRNLTFQGFAGPVTLDDSGDIDNIMSLLYVSLDTRKYKVLMKYDTHKNKTIPVAENPNF 413

  Fly   613 ----------------IVIDMVVFT---FLTSLLFISWF-------------KKVCWWRCV--EN 643
                            .::.:.|||   .|..||.|:..             ||   |..:  ||
Mouse   414 IWKNHKLPNDVPGLGPQILMIAVFTLTGILVVLLLIALLVLRKYRRDHALRQKK---WSHIPSEN 475

  Fly   644 -----------------DSRKYGRV----SCKLFK---IWERIQHS---FVLRVTIYMS--IVAS 679
                             |.|:...:    .||..|   |.:.::||   |..:..|.::  :.:.
Mouse   476 IFPLETNETNHISLKIDDDRRRDTIQRVRQCKYDKKKVILKDLKHSDGNFSEKQKIDLNKLLQSD 540

  Fly   680 YYLL---ISTILLN---------CDKNQYELDVINSKLYHYDIVTDNCFNPWVFTDMI--SLIVG 730
            ||.|   ..|:.|:         |::.... :|:|..:.:    .|..|..|.|...:  .:..|
Mouse   541 YYNLTKFYGTVKLDTRIFGVVEYCERGSLR-EVLNDTISY----PDGTFMDWEFKISVLNDIAKG 600

  Fly   731 VSYTF-ARIPFALKMLITCCATVAYLV--IVFFQYSFIF----------EHSATTTPFMKAELAH 782
            :||.. ::|....::..|.|...:.:|  |..|..:.|.          ||....|...|.::..
Mouse   601 MSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQATISQKGDVYS 665

  Fly   783 CLRVCMMLL----TMYAKERQSEFNTKINFKINQ--------DL--------------------- 814
            ...:...::    |.|....: :.|.|| |::..        ||
Mouse   666 FAIIAQEIILRKETFYTLSCR-DHNEKI-FRVENSYGKPFRPDLFLETADEKELEVYLLVKSCWE 728

  Fly   815 QGKQKAADITN-KSIIILLTNILPSHVVEVYLDSVANH-ELYYEN-------------------- 857
            :..:|..|... :|.:..:..:......|.|:|::... :||..|
Mouse   729 EDPEKRPDFKKIESTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRAD 793

  Fly   858 -------------------------YKMVSVMFAMLINF------QMDLPSLRVLNDIITEFDRL 891
                                     |:.|::.|:.::.|      ...:..:.:||||...||::
Mouse   794 HLNFMLLPRLVVKSLKEKGIVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDQI 858

  Fly   892 LNAYKEYYVVEKIKVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHDE 956
            :    :::.|.|::.:|..|:.|.||..     :.|:| ||...|::..              |.
Mouse   859 V----DHHDVYKVETIGDAYVVASGLPM-----RNGNR-HAVDISKMAL--------------DI 899

  Fly   957 VAFIMTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPV 1021
            ::|| .||.|:.:..|.|.                 |.||:.:|...|||||...|.|.::|:.|
Mouse   900 LSFI-GTFELEHLPGLPVW-----------------IRIGVHSGPCAAGVVGIKMPRYCLFGDTV 946

  Fly  1022 NMASRMESTGLPGHIHVTQETANILEQFDIMCMY--RGMTFVKGRGEIPTYFV-GIDD---NLKF 1080
            |.||||||||||..||::..|..||::.|...:|  ||.|::||||...||:: |:.|   ||..
Mouse   947 NTASRMESTGLPLRIHMSSSTITILKRTDCQFLYEVRGETYLKGRGTETTYWLTGMKDQEYNLPS 1011

  Fly  1081 LPSNVKKNNMSKRFS--ILSSL 1100
            .|:...:..:...||  |:|:|
Mouse  1012 PPTVENQQRLQTEFSDMIVSAL 1033

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AcyC	85..452	CDD:441717	41/245 (17%)
		Nucleotidyl_cyc_III	298..484	CDD:448371	36/211 (17%)
		Nucleotidyl_cyc_III	853..1072	CDD:448371	73/271 (27%)
Gucy2c	NP_001120790.1	Periplasmic_Binding_Protein_type1	35..415	CDD:471960	70/442 (16%)
		Protein Kinases, catalytic domain	480..749	CDD:473864	47/275 (17%)
		CYCc	787..978	CDD:214485	60/232 (26%)