DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ACXB and Gucy2c

DIOPT Version :9

Sequence 1:NP_620474.2 Gene:ACXB / 53427 FlyBaseID:FBgn0040509 Length:1114 Species:Drosophila melanogaster
Sequence 2:NP_001120790.1 Gene:Gucy2c / 14917 MGIID:106903 Length:1072 Species:Mus musculus


Alignment Length:1127 Identity:219/1127 - (19%)
Similarity:386/1127 - (34%) Gaps:386/1127 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   245 WLRQARQQ--------ESMLLDSILPPQIAKPIQQSIKE-----RIMLSETDSDRIVVNARRTEN 296
            |..|.||.        ..:::|:....:..:.::::::|     |..|.|.|.: :.|||     
Mouse    22 WASQVRQNCRNGSYEISVLMMDNSAYKEPMQNLREAVEEGLDIVRKRLREADLN-VTVNA----- 80

  Fly   297 FMAIQIHPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCV 361
                      :.:|:|                 .::|.                   .|||....
Mouse    81 ----------TFIYSD-----------------GLIHK-------------------SGDCRSST 99

  Fly   362 AG----LGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGT---------LLAGVI 413
            ..    |.|...||......:|.|...:..::.....|:..|   :.:|:         .|..::
Mouse   100 CEGLDLLREITRDHKMGCALMGPSCTYSTFQMYLDTELNYPM---ISAGSYGLSCDYKETLTRIL 161

  Fly   414 GQA-KLQY---DIWGPDVDIANRLEATGKP-----GYVHVSGRTLSS----LNVAEYTVFPGTEV 465
            ..| ||.|   |.|..:       .|:.||     .||:.:|.....    ||..|..|...:||
Mouse   162 PPARKLMYFLVDFWKVN-------NASFKPFSWNSSYVYKNGSEPEDCFWYLNALEAGVSYFSEV 219

  Fly   466 AQSDPILQKQPMTTYLLTAAPSR-NSVRSVDAVHSYAEIDINALGASRKSPILRPTLMSDELREE 529
            .....:|::......:||....: |.:.......|:.::. ..|..:..:.::...|.|:...||
Mouse   220 LNFKDVLRRSEQFQEILTGHNRKSNVIVMCGTPESFYDVK-GDLQVAEDTVVILVDLFSNHYFEE 283

  Fly   530 FKKMPVGGFNI---RSPCCRDNSND---EKVNHGLGMFCVAFKDSSLEWSYLHK----------- 577
            ....|....|:   ..|..:..||.   |:.:.|...|.:|:.:.:|.:.::.:           
Mouse   284 NTTAPEYMDNVLVLTLPSEQSTSNTSVAERFSSGRSDFSLAYLEGTLLFGHMLQTFLENGENVTG 348

  Fly   578 PDFILKYSVLLAWGIG--------------CCLIYIQIVNDKFTICVEC---------------- 612
            |.|...:..|...|..              ..|:|:.:...|:.:.::.                
Mouse   349 PKFARAFRNLTFQGFAGPVTLDDSGDIDNIMSLLYVSLDTRKYKVLMKYDTHKNKTIPVAENPNF 413

  Fly   613 ----------------IVIDMVVFT---FLTSLLFISWF-------------KKVCWWRCV--EN 643
                            .::.:.|||   .|..||.|:..             ||   |..:  ||
Mouse   414 IWKNHKLPNDVPGLGPQILMIAVFTLTGILVVLLLIALLVLRKYRRDHALRQKK---WSHIPSEN 475

  Fly   644 -----------------DSRKYGRV----SCKLFK---IWERIQHS---FVLRVTIYMS--IVAS 679
                             |.|:...:    .||..|   |.:.::||   |..:..|.::  :.:.
Mouse   476 IFPLETNETNHISLKIDDDRRRDTIQRVRQCKYDKKKVILKDLKHSDGNFSEKQKIDLNKLLQSD 540

  Fly   680 YYLL---ISTILLN---------CDKNQYELDVINSKLYHYDIVTDNCFNPWVFTDMI--SLIVG 730
            ||.|   ..|:.|:         |::.... :|:|..:.:    .|..|..|.|...:  .:..|
Mouse   541 YYNLTKFYGTVKLDTRIFGVVEYCERGSLR-EVLNDTISY----PDGTFMDWEFKISVLNDIAKG 600

  Fly   731 VSYTF-ARIPFALKMLITCCATVAYLV--IVFFQYSFIF----------EHSATTTPFMKAELAH 782
            :||.. ::|....::..|.|...:.:|  |..|..:.|.          ||....|...|.::..
Mouse   601 MSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQATISQKGDVYS 665

  Fly   783 CLRVCMMLL----TMYAKERQSEFNTKINFKINQ--------DL--------------------- 814
            ...:...::    |.|....: :.|.|| |::..        ||                     
Mouse   666 FAIIAQEIILRKETFYTLSCR-DHNEKI-FRVENSYGKPFRPDLFLETADEKELEVYLLVKSCWE 728

  Fly   815 QGKQKAADITN-KSIIILLTNILPSHVVEVYLDSVANH-ELYYEN-------------------- 857
            :..:|..|... :|.:..:..:......|.|:|::... :||..|                    
Mouse   729 EDPEKRPDFKKIESTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRAD 793

  Fly   858 -------------------------YKMVSVMFAMLINF------QMDLPSLRVLNDIITEFDRL 891
                                     |:.|::.|:.::.|      ...:..:.:||||...||::
Mouse   794 HLNFMLLPRLVVKSLKEKGIVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDQI 858

  Fly   892 LNAYKEYYVVEKIKVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHDE 956
            :    :::.|.|::.:|..|:.|.||..     :.|:| ||...|::..              |.
Mouse   859 V----DHHDVYKVETIGDAYVVASGLPM-----RNGNR-HAVDISKMAL--------------DI 899

  Fly   957 VAFIMTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPV 1021
            ::|| .||.|:.:..|.|.                 |.||:.:|...|||||...|.|.::|:.|
Mouse   900 LSFI-GTFELEHLPGLPVW-----------------IRIGVHSGPCAAGVVGIKMPRYCLFGDTV 946

  Fly  1022 NMASRMESTGLPGHIHVTQETANILEQFDIMCMY--RGMTFVKGRGEIPTYFV-GIDD---NLKF 1080
            |.||||||||||..||::..|..||::.|...:|  ||.|::||||...||:: |:.|   ||..
Mouse   947 NTASRMESTGLPLRIHMSSSTITILKRTDCQFLYEVRGETYLKGRGTETTYWLTGMKDQEYNLPS 1011

  Fly  1081 LPSNVKKNNMSKRFS--ILSSL 1100
            .|:...:..:...||  |:|:|
Mouse  1012 PPTVENQQRLQTEFSDMIVSAL 1033

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXBNP_620474.2 AC_N <36..276 CDD:292831 6/43 (14%)
CYCc 249..459 CDD:214485 42/248 (17%)
Nucleotidyl_cyc_III 298..484 CDD:299850 36/211 (17%)
CYCc 825..1047 CDD:214485 65/274 (24%)
Nucleotidyl_cyc_III 853..1072 CDD:299850 73/271 (27%)
Gucy2cNP_001120790.1 Periplasmic_Binding_Protein_Type_1 35..415 CDD:299141 70/442 (16%)
PKc_like 480..749 CDD:304357 47/275 (17%)
STYKc 502..744 CDD:214568 45/248 (18%)
CYCc 787..978 CDD:214485 60/232 (26%)
Guanylate_cyc 814..1001 CDD:278633 70/228 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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