DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXB and LRRK2

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	NP_940980.4	Gene:	LRRK2 / 120892	HGNCID:	18618	Length:	2527	Species:	Homo sapiens

Alignment Length:	1220	Identity:	225/1220 - (18%)
Similarity:	388/1220 - (31%)	Gaps:	447/1220 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 EDISEVVHDLDTICVDIFHYLGFNLMGIF-------FRIMN---------------------DTM 228
            |::::||..|:.:.::     |..:.||.       .:|:|                     ...
Human  1100 ENLTDVVEKLEQLILE-----GNKISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFS 1159

  Fly   229 VRSSFLDRHQFLKEEMWLRQARQQE-SMLLDSILP-PQI------AKPIQ--------QSIKERI 277
            .|.:||....||...|.:.:..|.: |.:.::||. |.:      :..||        :|:..|.
Human  1160 ARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRE 1224

  Fly   278 MLSETDSDRIVVNARRTENFMAI-----------QIHPDVSILYADVVNYTHLTTTLTVE----- 326
            :|...:...|:..:.:...:..:           :|.|::..|    .|.|.|..:..:|
Human  1225 LLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCL----ENLTSLDVSYNLELRSFP 1285

  Fly   327 ----KLVKV----LHDLYGRFDMAASTFKVQR-IKFLGDCYYCVAGLGEADPDHARMAVSL---- 378
                ||.|:    |.:|:..||......|.:. |:||..      .|.:|.| :.||.:.:
Human  1286 NEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQ------RLKKAVP-YNRMKLMIVGNT 1343

  Fly   379 GISMIANIQEVRAHRALDIDMR---IGVHSGTLLAGVIGQAK--LQYDIWGPDVDIANRLEATGK 438
            |......:|::...:..|:.|:   :|:........:..:.|  |..::|    |.|.|.|...
Human  1344 GSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLNVW----DFAGREEFYS- 1403

  Fly   439 PGYVHVSGRTLSSLNVAEYTVFPG-TEV-------------AQSDPIL----------QKQ---- 475
               .|....|..:|.:|.|.:..| .||             |.|.|::          :||
Human  1404 ---THPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRKAC 1465

  Fly   476 --PMTTYLLTAAPSRNSVRSVDAVHSYAEIDINALGASRKSPILRPTLMSDELREEFKKMPVGGF 538
              .:|..||       :.|...|:..|.  .:||...|.....||.|::::.|..:.:...|.|.
Human  1466 MSKITKELL-------NKRGFPAIRDYH--FVNATEESDALAKLRKTIINESLNFKIRDQLVVGQ 1521

  Fly   539 NIRSPCC-------------------------------RDNS---NDEKVNHGLGMF-----CVA 564
            .|  |.|                               |:|.   ::.::.|.:...     .:.
Human  1522 LI--PDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNESGVLLH 1584

  Fly   565 FKDSSLEWSYLHKPDFILKYSVLLAWGIGCCLIYIQIVNDKFTIC---VECIVIDMVVFTFLTSL 626
            |:|.:|:.|.|        |.|...|   .|.|..||:..|...|   .:.|:....|..||:
Human  1585 FQDPALQLSDL--------YFVEPKW---LCKIMAQILTVKVEGCPKHPKGIISRRDVEKFLS-- 1636

  Fly   627 LFISWFKKVCWWRCVENDSRKYGR-VSCKLFKIWERIQHSFVLRVTIYMSIVASYYLLISTI--- 687
                  ||           ||:.: ...:.||:.|:.|        |.:.|...|.|:.|::
Human  1637 ------KK-----------RKFPKNYMSQYFKLLEKFQ--------IALPIGEEYLLVPSSLSDH 1676

  Fly   688 -----LLNCDKNQYELDVINSKLYHYDIVTDNCFNPWVFTDMISLIVGVS-YTFARIPFALKMLI 746
                 |.:|:.::     |..:||....     |....::.:|:.::.:| |..:....||:...
Human  1677 RPVIELPHCENSE-----IIIRLYEMPY-----FPMGFWSRLINRLLEISPYMLSGRERALRPNR 1731

  Fly   747 TCCATVAYLVIVFFQYSFIFEHSATTTP--FMKAELAHCLRVCMML------------------- 790
            .......||......|..:........|  |:|..:..|.:.|::|
Human  1732 MYWRQGIYLNWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLL 1796

  Fly   791 --------LTMYAKERQSEFN-----TKINFKINQDLQGKQKAADI----TNKSIIILLTNILPS 838
                    .|:..|.....||     .||   :..||..|.:..|:    ....:.|.::.|.|.
Human  1797 EIDICGEGETLLKKWALYSFNDGEEHQKI---LLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPD 1858

  Fly   839 HVVEVYLDSVANHELYYENYKMVSVMFAMLINFQMDLPSLRVLNDIITEFDRLLNAYKEYYVVEK 903
            .::                               .|||...:||:...||::
Human  1859 LIL-------------------------------ADLPRNIMLNNDELEFEQ------------- 1879

  Fly   904 IKVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGT-------------ENDHD 955
                        ..:|.|....|||...|:|  |.|:|..:..:|.|             ...|.
Human  1880 ------------APEFLLGDGSFGSVYRAAY--EGEEVAVKIFNKHTSLRLLRQELVVLCHLHHP 1930

  Fly   956 EVAFIMTTFALDLMRVLSVCNKAYAGRPF--DRALST----GEICIGISTG-----EIMAGVVGA 1009
            .:..::.......|.|:.:.:|....|..  |:|..|    ..|.:.::.|     ..|. :...
Human  1931 SLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMI-IYRD 1994

  Fly  1010 SQPH----YDIWGNPVNMAS-----------RM---ESTGLPGHIHVTQETANIL--EQFDI--- 1051
            .:||    :.::.|...:|.           ||   .|.|.||.........|::  :|.|:
Human  1995 LKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSF 2059

  Fly  1052 -MCMY----RGMTFVKGRGEIPTYFVGIDDNLKF---LPSNVK------------------KNNM 1090
             :.:|    .|...|:|. :.|..|    |.|:.   ||..||                  |.|.
Human  2060 GLLLYDILTTGGRIVEGL-KFPNEF----DELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENP 2119

  Fly  1091 SKR------FSILSS--------------------LVPVHSRSTTSSEYI 1114
            .:|      |.||:|                    :|..|..|..:|.::
Human  2120 QERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWL 2169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	23/127 (18%)
		CYCc	249..459	CDD:214485	51/259 (20%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	51/249 (20%)
		CYCc	825..1047	CDD:214485	44/265 (17%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	48/270 (18%)
LRRK2	NP_940980.4	Required for RAB29-mediated activation. /evidence=ECO:0000269\|PubMed:29212815	1..969
		LRR 1	983..1004
		leucine-rich repeat	985..1012	CDD:275380
		LRR	1012..>1286	CDD:227223	33/194 (17%)
		LRR 2	1012..1033
		leucine-rich repeat	1013..1036	CDD:275380
		LRR 3	1036..1057
		leucine-rich repeat	1037..1084	CDD:275380
		LRR 4	1059..1080
		LRR 5	1084..1105		1/4 (25%)
		leucine-rich repeat	1085..1108	CDD:275380	3/7 (43%)
		LRR 6	1108..1129		4/25 (16%)
		leucine-rich repeat	1109..1130	CDD:275380	4/25 (16%)
		LRR 7	1130..1150		2/19 (11%)
		leucine-rich repeat	1131..1174	CDD:275380	7/42 (17%)
		LRR 8	1174..1196		5/21 (24%)
		leucine-rich repeat	1175..1197	CDD:275380	5/21 (24%)
		LRR 9	1197..1218		2/20 (10%)
		leucine-rich repeat	1198..1221	CDD:275380	3/22 (14%)
		LRR 10	1221..1241		3/19 (16%)
		leucine-rich repeat	1222..1246	CDD:275380	3/23 (13%)
		LRR 11	1246..1267		2/20 (10%)
		leucine-rich repeat	1247..1269	CDD:275380	3/25 (12%)
		LRR 12	1269..1291		4/21 (19%)
		RocCOR	1334..1507	CDD:206741	39/189 (21%)
		COR	1527..1740	CDD:318343	45/260 (17%)
		STKc_LRRK2	1884..2135	CDD:270970	53/258 (21%)
		WD 1	2139..2183		4/31 (13%)
		WD 2	2188..2228
		WD 3	2233..2276
		WD 4	2281..2327
		WD 5	2333..2377
		WD 6	2402..2438
		WD 7	2443..2497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900