DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXB and Adcy9

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	XP_011244107.1	Gene:	Adcy9 / 11515	MGIID:	108450	Length:	1372	Species:	Mus musculus

Alignment Length:	1314	Identity:	290/1314 - (22%)
Similarity:	489/1314 - (37%)	Gaps:	406/1314 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 RLWERGYLKAKCKELCLEEEYKKYQIRLMISYLTVFFPLFIFVVVGCELCPWIFS-EQKKLIYYE 83
            |.|:..:.....:|.|||..:.:.|.|..       :.|| :|...|.|....|: ..|..:...
Mouse    89 RWWDPKFDSMNLEEACLERCFPQTQRRFR-------YALF-YVGFACLLWSIYFAVHMKSKVIVM 145

  Fly    84 SLTAIVVLVAVPGILSINFFESFVLRHRW------IMVFSSILSAYIVVLVDIFQILVFHFKYHW 142
            .:.|:..||...|.....|.:.:...:.|      ::||:..|:|.       ||:        |
Mouse   146 VVPALCFLVVCVGFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQ-------FQV--------W 195

  Fly   143 -PLNTLYD------------------------VFVLCMIYMFLPIPSIRGAALLATSVSLMYIGL 182
             ||:...|                        :.||.::|..:.:|              :|:.|
Mouse   196 TPLSGRVDSSNHTLTATPADTCLSQVGSFSICIEVLLLLYTVMQLP--------------LYLSL 246

  Fly   183 FI------------YFLKSDD------------EDISE-VVHDLDTICVDIFHYLGFNLMGIFFR 222
            |:            |..:::|            |.:|. ::|    :|:   |.:|.:|.
Mouse   247 FLGVVYSVLFETFGYHFRNEDCYPSPGPGALHWELLSRALLH----VCI---HAIGIHLF----- 299

  Fly   223 IMNDTMVRSSFLDRHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSIKERIMLSETDSDRI 287
            :|:....||:||...|.:.....|...:..:..::.|::|..||..:.:...|.   ||....|.
Mouse   300 VMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEE---SENSVKRH 361

  Fly   288 VVNA-RRTENFMAIQIHP------------DVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRF 339
            ..:: :..:...:||..|            :||||:||:|.:|.::...:...||.:|:||:|||
Mouse   362 ATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRF 426

  Fly   340 DMAASTFKVQRIKFLGDCYYCVAGLGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVH 404
            |......|.::|..||||||||||..|...|||...:.:|:.||..|::....:...::||:|||
Mouse   427 DRLCEQTKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVH 491

  Fly   405 SGTLLAGVIGQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPG---TEVA 466
            :||:|.|::|..:.::|:|..||::||.:|..|..|.||:|..|...|: ..|.:..|   ..:.
Mouse   492 TGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD-DRYEMEDGRVIERLG 555

  Fly   467 QSDPILQKQPMTTYLLTAAPSRNSVRS-VDAVHSYAEI--DINALGASRKSPILRPTLMSD---- 524
            ||....|.:.:.|||::...::.|..| .:|:.|..|:  |.......|......|..:||
Mouse   556 QSVVADQLKGLKTYLISGQRAKESHCSCAEALLSGFEVIDDSRESSGPRGQGTASPGSVSDLAQT 620

  Fly   525 -ELREEFKKMPVGG--FNIRSPC----------CRD----------------------------- 547
             :..:..|..|..|  |..:|..          |:|
Mouse   621 VKTFDNLKTCPSCGITFAPKSEAGAEGGTVQNGCQDEPKTSTKVTSSWLLFLSVPLLAHPPKASG 685

  Fly   548 --NSN----------DEKVNHGLGMFCV------------------------------------A 564
              ||.          :||:.:.....|.                                    .
Mouse   686 GPNSKTQNGLLSPPAEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDV 750

  Fly   565 FKDSSLEWSYLHKP--------------------------------------------DFILKYS 585
            .|:.||...|..||                                            |..|..:
Mouse   751 IKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFASATFSSLLDVFLSTT 815

  Fly   586 VLLAWGIGCCLIY-----------IQIVNDKFTICVECIVIDMVVFTFLTSLL-----FISWFKK 634
            |.|...|.|.|.|           :.:......:.|..:::.:.:..||..::     .:.|
Mouse   816 VFLILSITCFLKYGATATPPPPAALAVFGADLLLEVLSLIVSIRMVFFLEDVMTCTKWLLEW--- 877

  Fly   635 VCWW---RCVENDSRKYGR--VSCKLFKIWERIQHSFVLRVTIYMSIVASYYLLISTILLNCDKN 694
            :..|   .|:       |.  ||.....::..|...|  ...|::::.....:|::.:
Mouse   878 IAGWLPRHCI-------GAILVSLPALAVYSHITSEF--ETNIHVTMFTGSAVLVAVV------- 926

  Fly   695 QYELDVINSKLYHYDIVTDNC-FNPWVFTDMISLIVGVSYTFARIPFALKMLITCCATVAYLVIV 758
                        ||   .:.| .:.|: ...::.|||..       ..|.:.|:.|...:   ||
Mouse   927 ------------HY---CNFCQLSSWM-RSSLATIVGAG-------LLLLLHISLCQDSS---IV 965

  Fly   759 FFQYSFIFEHSATTTPFMKAELAH------------CLRVCMMLLTMYAKERQSEFNTKINF--K 809
            ..........||...|...:.|..            .|...::||.::...|:.|.:.::::  .
Mouse   966 MSPLDSAQNFSAQRNPCNSSVLQDGRRPASLIGKELILTFFLLLLLVWFLNREFEVSYRLHYHGD 1030

  Fly   810 INQDL-----QGKQKAADITNKSIIILLTNILPSHVVEVYLDSVANHELYYENYKMVSVMFAMLI 869
            :..||     |..:..||       .||.||:|.||.|    .:...:.|.:|:....|:||.::
Mouse  1031 VEADLHRTKIQSMRDQAD-------WLLRNIIPYHVAE----QLKVSQTYSKNHDSGGVIFASIV 1084

  Fly   870 NF--------QMDLPSLRVLNDIITEFDRLLNAYKEYYVVEKIKVVGCTYMAACGLDFTLAKSKF 926
            ||        :......||||::|.:||.||:. .:|..:||||.:|.|||||.||:  .|:.:.
Mouse  1085 NFSEFYEENYEGGKECYRVLNELIGDFDELLSK-PDYNSIEKIKTIGATYMAASGLN--TAQCQE 1146

  Fly   927 GSRTHASYSSELEQVLYRKESKGTENDHDEVAFIMTTFALDLMRVLSVCNKAYAGRPFDRALSTG 991
            |                     |...:|..:.|   .||.::|||:...|.......|
Mouse  1147 G---------------------GHPQEHLRILF---EFAKEMMRVVDDFNNNMLWFNF------- 1180

  Fly   992 EICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTQETANILEQFDIMCMYR 1056
            ::.:|.:.|.:.|||:|.::..|||||:.||:||||::||:...|.|::|:..:|.:......||
Mouse  1181 KLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYR 1245

  Fly  1057 GMTFVKGRGEIPTY 1070
            |...|||:|::.||
Mouse  1246 GTVNVKGKGQMKTY 1259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	54/296 (18%)
		CYCc	249..459	CDD:214485	73/222 (33%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	72/200 (36%)
		CYCc	825..1047	CDD:214485	71/229 (31%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	73/226 (32%)
Adcy9	XP_011244107.1	MFS	<134..260	CDD:391944	25/154 (16%)
		Guanylate_cyc	385..573	CDD:306677	69/188 (37%)
		Guanylate_cyc	1069..1260	CDD:306677	73/225 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810