DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXB and Adcy8

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	NP_033753.2	Gene:	Adcy8 / 11514	MGIID:	1341110	Length:	1249	Species:	Mus musculus

Alignment Length:	1155	Identity:	328/1155 - (28%)
Similarity:	526/1155 - (45%)	Gaps:	230/1155 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ERLWERGYLKAKCKELCLEEEYKKYQIRLMISYLTVFFPLFIFVV-VGCELCPWIFSEQKKLIYY 82
            |||::|.:|..:.|.            .::::.|.|...|.:.|: :.....|   .:..|.|..
Mouse   165 ERLYQRYFLGQRRKS------------EVVMNVLDVLTKLTLLVLHLSLASAP---MDPLKGILL 214

  Fly    83 ESLTAI-VVLVAVPGILSINFFESFVLRH----RWIMVFSSILSAYI--VVLVDIFQILVFHFKY 140
            ...|.| ||:.|:..:...|...:: |::    .|:.:.:.||:|.:  .:|.|
Mouse   215 GFFTGIEVVICALVVVRKDNTSHTY-LQYSGVVTWVAMTTQILAAGLGYGLLGD----------- 267

  Fly   141 HWPLNTLYDVFVLCMIYMFLPIPSIRGAALLATSVSLMYIGLFIYFLKSDDEDISEVVHDLDTIC 205
                ...|.:|.|...|..||:| :..|.|.....||:.:.|.:...:.       .|..::.:.
Mouse   268 ----GIGYVLFTLFATYSMLPLP-LTWAILAGLGTSLLQVTLQVLIPRL-------AVFSINQVL 320

  Fly   206 VDIFHYLGFNLMGIFFRIMNDTMVRSSFLDRHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQ 270
            ..:..::..|..|||...::|...|.:||:..:.::..:.|....|::..|:.|:||
Mouse   321 AQVVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLP-------- 377

  Fly   271 QSIKERIMLSETDSDRIVVNARRTEN-FMAIQIH--PDVSILYADVVNYTHLTTTLTVEKLVKVL 332
                 |.::.|..:|...|.....:: |..|.||  .:||||:|||..:|:|:|||:.::||::|
Mouse   378 -----RFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRML 437

  Fly   333 HDLYGRFDMAASTFKVQRIKFLGDCYYCVAGLGEADPDHARMAVSLGISMIANIQEVRAHRALDI 397
            ::|:.|||..|......|||.||||||||:||.|...|||...|.:|:|||..|:.||:....|:
Mouse   438 NELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRRDHAHCCVEMGLSMIKTIRFVRSRTKHDV 502

  Fly   398 DMRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPG 462
            |||||:|||::|.||:|..|.|:|:|..||||||:||:.|.||.:|:|..||..|| .:|.|..|
Mouse   503 DMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLN-GDYNVEEG 566

  Fly   463 TEVAQSDPILQKQPMTTYL-------LTAAPS---RNSVRSVDAVHSYA---------EIDI--- 505
             ...:.:..|:|..:.|||       |...|.   :.||...|..:|.|         |:..
Mouse   567 -HGKERNEFLRKHNIETYLIKQPEESLLCLPEDIVKESVSCSDRRNSGATFTEGSWSPELPFDNI 630

  Fly   506 ----NALGA-SRKSPILRPTLMSDELR-----EEFKKMPVGGFNIRSPCCRDNSNDEKVNHGLGM 560
                |.|.| :|.|..|.|..::..|.     ||..|......::|       |.|:.....:..
Mouse   631 VGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLR-------SGDKLRREHIKP 688

  Fly   561 FCVAFKDSSLEWSYLHKPDFILKYSVLLAWGIGCCLIYIQIVNDKFTICVECIVIDMVV-FTFL- 623
            |.:.|||||||..|....|.:.|.:::.|:.:   |::|..:.   ::.....::.|.: |:.|
Mouse   689 FSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIV---LLFITAIQ---SLLPSSRLMPMTIQFSILI 747

  Fly   624 ---TSLLFISW----------FKKVCWWRCVENDSRKYGRVSCKLFKIWERIQHSFVLR-VTIYM 674
               ::|:.|:.          .:|.|.|                       |..:::.| |.|:.
Mouse   748 MLHSALVLITTAEDYKCLPLILRKTCCW-----------------------INETYLARNVIIFA 789

  Fly   675 SIVASYYLLISTILLNCDKNQYELDVINSKLYHYDIVTDNCFNP--WVFTDMISLIVGVSYTFAR 737
            ||:.::...:..||. ||.:: .:.:.|.......:.||.|..|  :|||.:::::  ....|.|
Mouse   790 SILINFLGAVLNILW-CDFDK-SIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMV--TCAVFLR 850

  Fly   738 IPFALKMLITCCATVAYLVIVFFQYSFIF------EHSATTTPFMKAELAHCLRVCMMLLTMYAK 796
            :...||:.:.......|.::....|:.:|      .||.  ..|:..:.|..|.:.|.||.::..
Mouse   851 LNSVLKLAVLLIMIAIYALLTETIYAGLFLSYDNLNHSG--EDFLGTKEASLLLMAMFLLAVFYH 913

  Fly   797 ERQSEFNTKINFKINQDLQGKQKAADIT-----NKSIIILLTNILPSHVVEVYLDSVA-NHELYY 855
            .:|.|:..:::|...  :|.|::..::.     |::   :|.|||||||...:|:... |.|||.
Mouse   914 GQQLEYTARLDFLWR--VQAKEEINEMKELREHNEN---MLRNILPSHVARHFLEKDRDNEELYS 973

  Fly   856 ENYKMVSVMFAMLINF----------QMDLPSLRVLNDIITEFDRLLNAYKEYYVVEKIKVVGCT 910
            ::|..|.||||.:..|          ...:..||:||:||.:||.||.. ..:..:||||.:|.|
Mouse   974 QSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGE-DRFQDIEKIKTIGST 1037

  Fly   911 YMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAFI--MTTFALDLMRVLS 973
            |||..||                 |.|.:|.            .|:...:  :..|:|.|...:.
Mouse  1038 YMAVSGL-----------------SPEKQQC------------EDKWGHLCALADFSLALTESIQ 1073

  Fly   974 VCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHV 1038
            ..||        .:.:..|:.||||.|.::|||:||.:|.|||||..||:||||:|||:.|.|.|
Mouse  1074 EINK--------HSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQV 1130

  Fly  1039 TQETANILEQFDIMCMYRGMTFVKG----RGEIPTYFV--GIDDNLKFLP 1082
            .:||..||:.......|||..:|||    .|:|.|||:  .:..|...||
Mouse  1131 PEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILP 1180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	47/247 (19%)
		CYCc	249..459	CDD:214485	93/212 (44%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	91/194 (47%)
		CYCc	825..1047	CDD:214485	83/234 (35%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	82/234 (35%)
Adcy8	NP_033753.2	Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1..180		6/26 (23%)
		Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1..107
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..33
		Essential for CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	38..40
		Essential for CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	49..51
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..118
		AC_N	<159..398	CDD:292831	57/284 (20%)
		CYCc	364..562	CDD:214485	92/211 (44%)
		Guanylate_cyc	403..587	CDD:278633	90/185 (49%)
		DUF1053	615..709	CDD:283888	25/100 (25%)
		CYCc	942..1146	CDD:214485	84/244 (34%)
		Guanylate_cyc	971..1170	CDD:278633	83/236 (35%)
		Involved in CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1107..1249		34/74 (46%)
		Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250\|UniProtKB:P40146	1198..1213
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1221..1249
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810