Protein Alignment ACXB and Adcy7

DIOPT Version :9

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: XP_006530643.1
• Gene: Adcy7 / 11513
• MGIID: 102891
• Length: 1146
• Species: Mus musculus
• Alignment Length: 1197
• Identity: 328/1197 - (27%)
• Similarity: 527/1197 - (44%)
• Gaps: 262/1197 - (21%)

  Fly    38 EEYKKYQIRLMISY--LTVFFPLFIFVVVGCELCPWIFSEQKKLIYYESLTAIVVLVAVPGILSI 100
            |:.:::|:.|..::  ||:|..|::.|.|.|.:..|             |.|:.:|.
Mouse    57 EDLRRHQVVLGTAFLMLTLFVALYVLVYVECLVQRW-------------LRALALLT-------- 100

  Fly   101 NFFESFVLRHRW--IMVFSSIL-------SAYIVVLVDIFQILVFHFKYHWPLNTLYDVFVLCMI 156
                       |  :||..|:|       .|:....|..|                  :||:.::
Mouse   101 -----------WACLMVLGSVLMWDSLENEAHAWEQVPFF------------------LFVVFVV 136

  Fly   157 YMFLPIPSIRGAALLATSVSLMYIGLFIYFLKSDDEDISEVVHDLDTICVDIFHYLGFNLMGIFF 221
            |..||: |.|.|.:...:.::.::.:|....::....:|.....|..:...:. .||.|..|.|.
Mouse   137 YALLPL-SRRAAIVAGVTSTVSHLLVFGAVTRAFQTSMSSTQLGLQLLANAVI-LLGGNFTGAFH 199

  Fly   222 RIMNDTMVRSSFLDRHQFLKEEMWLR-QARQQESMLLDSILPPQIAKPIQQSIKERIMLSETDSD 285
            :.......|..|:...:.::....|| :.||||::|| |:||..|:..::.:|.||:   :...|
Mouse   200 KHQLQDASRDLFIYTVKCIQIRRKLRVEKRQQENLLL-SVLPAHISMGMKLAIIERL---KEGGD 260

  Fly   286 RIVVNARRTENFMAIQI--HPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKV 348
            |   :.....||.::.:  |.:|||||||:|.:|.|.:..:.::||.||::|:|:||..|...:.
Mouse   261 R---HYMPDNNFHSLYVKRHQNVSILYADIVGFTRLASDCSPKELVVVLNELFGKFDQIAKANEC 322

  Fly   349 QRIKFLGDCYYCVAGLGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVI 413
            .|||.||||||||:||..:.|.|||..|.:|:.:...|::||....:||.||:|:|||.:|.|||
Mouse   323 MRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDICEAIKQVREATGVDISMRVGIHSGNVLCGVI 387

  Fly   414 GQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPMT 478
            |..|.|||:|..||.:|||:||.|.||.||::..||:.|:.| |.|..| ...|.||.|::..:.
Mouse   388 GLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLNHLDKA-YEVEDG-HGEQRDPYLKEMNIR 450

  Fly   479 TYLL-------TAAPS--------------RNSVR------SVDAVHSYAEIDINALGASRKSPI 516
            |||:       ...||              |.|||      |..|...:|.::.....:|.::||
Mouse   451 TYLVIDPRSQQPPPPSHHLSKPKGDATLKMRASVRVTRYLESWGAARPFAHLNHRESVSSSETPI 515

  Fly   517 ----------LR-----------PTLMSDELREEFKKMPVGGFNIRSPCCRDNSNDEKVNHGLGM 560
                      ||           ...:.|:..:|... .:.|.:...||| ..|:|   .|..|.
Mouse   516 SNGRRQKAIPLRRHRAPDRSASPKGRLEDDCDDEMLS-AIEGLSSTRPCC-SKSDD---FHTFGP 575

  Fly   561 FCVAFKDSSLEWSYLHKPDFILKYSVLLAWGIGCC--LIYIQIVNDKFTI-----CVECIVIDMV 618
            .   |.:...|..|...|....:|....|..:..|  |:::.::....|:     .|.|::..::
Mouse   576 I---FLEKGFEREYRLVPIPRARYDFACASLVFVCILLVHLLVMPRMATLGVSFGLVACLLGLVL 637

  Fly   619 VFTFLTSLLFISWFKKVCWWRCVENDSRKYGRVSCKLFKIWERIQHSFVLRVTIYMSIVASYYLL 683
            .|.|.|.           :.||..:.|        .|..|.|.::...::|:.:.:..|.|   |
Mouse   638 SFCFATE-----------FSRCFPSRS--------TLQAISESVETQPLVRLVLVVLTVGS---L 680

  Fly   684 ISTILLNCDKN-----QYELDVINSKLYHYDIVTDNC-FNPWVFTDMISLIVGVSYTFARIPFAL 742
            ::..::|....     :...|...|.|...:.|...| ..|:.....|...:..| .|.|:...|
Mouse   681 LTVAIINMPLTLNPGPEQPGDNKTSPLAAQNRVGTPCELLPYYTCSCILGFIACS-VFLRMSLEL 744

  Fly   743 KMLITCCATVAYLVIVFFQYSFIFEHSATTT---------------------------------- 773
            |.::...|.||||::  |..|..:..|..:|
Mouse   745 KAMLLTVALVAYLLL--FNLSPCWHVSGNSTETNGTQRTRLLLSDAQSMPSHTLAPGARETAPSP 807

  Fly   774 PFMKAELAHCLRVCMMLLTMYAK----ERQSEFNTKINFKINQDLQGKQKAADITNKSIIILLTN 834
            .:::.:|.  :.|...|:..||.    .||.::..:::....:..:.:.:..:.......:||.|
Mouse   808 SYLERDLK--IMVNFYLILFYATLILLSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLEN 870

  Fly   835 ILPSHVVEVYLDSVANHELYYENYKMVSVMFAMLINFQM----------DLPSLRVLNDIITEFD 889
            :||:||...::...|..:.|:::|..|.||||.:.:|::          .|..||:||:||.:||
Mouse   871 VLPAHVAAHFIGDKAAEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFD 935

  Fly   890 RLLNAYKEYYVVEKIKVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDH 954
            .||...| :..|||||.:|.|||||.||              ::.|....|.|.||        |
Mouse   936 ELLLKPK-FSGVEKIKTIGSTYMAAAGL--------------SAPSGHENQDLERK--------H 977

  Fly   955 DEVAFIMTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGN 1019
            ..:. ::..|::.||..|...|:        .:.::..:.:||:.|.::|||:||.:|.||||||
Mouse   978 VHIG-VLVEFSMALMSKLDGINR--------HSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGN 1033

  Fly  1020 PVNMASRMESTGLPGHIHVTQETANILEQFDIMCMYRGMTFVKGRGEIPTYFVGIDDNLKFLPSN 1084
            .||:||||||||..|.|.||:||..||:.....|..||:..|||:||:.|||     .|.||..:
Mouse  1034 TVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYF-----ELFFLNPS 1093

  Fly  1085 VKKNNMSKRFSILSSLVPVHSRSTTSS 1111
            |.:..:|      .||:...|.:|.|:
Mouse  1094 VGQGFVS------GSLLRRPSLTTDSN 1114

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	53/249 (21%)
		CYCc	249..459	CDD:214485	94/211 (45%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	86/194 (44%)
		CYCc	825..1047	CDD:214485	84/231 (36%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	87/228 (38%)
Adcy7	XP_006530643.1	AC_N	<75..251	CDD:318454	47/228 (21%)
		Guanylate_cyc	272..422	CDD:306677	72/149 (48%)
		DUF1053	487..593	CDD:399378	22/113 (19%)
		Guanylate_cyc	890..1085	CDD:306677	86/226 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870