Protein Alignment ACXB and Adcy6

DIOPT Version :10

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: XP_006520366.3
• Gene: Adcy6 / 11512
• MGIID: 87917
• Length: 1254
• Species: Mus musculus
• Alignment Length: 1135
• Identity: 297/1135 - (26%)
• Similarity: 509/1135 - (44%)
• Gaps: 206/1135 - (18%)

  Fly    36 LEEEYKKYQIRLMISYLTVFFPLFIF---VVVGCELCPWIFSEQKKLIYYESLTAIVVLVAVPGI 97
            ||..|::|..::..|.||:...:.:.   |::.....|    .|.:..|...||...||..|  :
Mouse   222 LERLYQRYFFQMNQSSLTLLMAVLVLLMAVLLTFHAAP----AQPQPAYVALLTCASVLFVV--L 280

  Fly    98 LSINFFESFVLRHRWIM--VFSSILSAYIVVLVDIFQILVFHFKYHWPLNTLY-DVFVLCMIYMF 159
            :.:....||.....|::  |...||:|     |.:...|..:  .|.|...|: .||.:.:.|..
Mouse   281 MVVCNRHSFRQDSMWVVSYVVLGILAA-----VQVGGALAAN--PHSPSAGLWCPVFFVYITYTL 338

  Fly   160 LPIPSIRGAALLATSVSLMYIGLFIYFLKSDDEDISEVVHDLDTICVDIFHYLGFNLMGIFFRIM 224
            ||| .:|.|.|....:|.::: :..:.|.|.|..:.:      .:..::..:|..|.:|:.....
Mouse   339 LPI-RMRAAVLSGLGLSTLHL-ILAWQLNSSDPFLWK------QLGANVVLFLCTNAIGVCTHYP 395

  Fly   225 NDTMVRSSFLDRHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSI---KERIMLSETDSDR 286
            .:...|.:|.:...:::..:.|:...:|:..||.|:||..:|..:::.|   ||.:|..:
Mouse   396 AEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHK----- 455

  Fly   287 IVVNARRTENFMAIQIHPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRI 351
                       :.||.|.:||||:||:..:|.|.:..|.::||..|::|:.|||..|:.....||
Mouse   456 -----------IYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI 509

  Fly   352 KFLGDCYYCVAGLGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVIGQA 416
            |.||||||||:||.||..|||...|.:|:.||..|..||....::::||:|:|||.:..||:|..
Mouse   510 KILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLR 574

  Fly   417 KLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPMTTYL 481
            |.|:|:|..||.:||.:||.|:.|.:|::..||..|| .:|.|.|| ...:.:..|::|.:.|:|
Mouse   575 KWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLN-GDYEVEPG-RGGERNAYLKEQCIETFL 637

  Fly   482 -LTAAPSRNSVRSVDAVHSYAEIDINALGASRKSPI--LRPTLMSDEL------REEFKKMPVGG 537
             |.|:..|...:::          :..|..:|.:.:  |.|..:.|..      .:.|::|.:..
Mouse   638 ILGASQKRKEEKAM----------LAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDD 692

  Fly   538 FNIRSPCCRDNSN-DEKVNHGLG-----------------MFCVAFKDSSLEWSYLHKPDFILKY 584
            .:..:...:|..| :::|:..||                 .|.:.|:...||..|..|.|.....
Mouse   693 SSKDNRGAQDALNPEDEVDEFLGRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGA 757

  Fly   585 SVLLAWGIGCCLIYIQIVNDKFTICVECIVIDMVVFTFLTSLLFISWFKKVCWWRCVENDSRKYG 649
            .|..|..:.|.:.:||::...::..:..|...:.:...:|.|:.     .||
Mouse   758 YVACALLVFCFICFIQLLVFPYSTLILGIYAAIFLLLLVTVLIC-----AVC------------- 804

  Fly   650 RVSCKLF--KIWERIQHSFVLR------------VTIYMSIVASYYLLISTILLNCDKNQYEL-- 698
              ||..|  |..:|:..:.|..            :.:::|.:|:.:....|.:..|......|
Mouse   805 --SCGSFFPKALQRLSRNIVRSRVHSTAVGIFSVLLVFISAIANMFTCNHTPIRTCAARMLNLTP 867

  Fly   699 -DVINSKL--YHYDIVTD---------NCFNPWVFTDMISLIVGVSYTFARIPFALKMLITCCAT 751
             ||....|  .:|.:..|         .|..|..|...:.|.:..|..|..|....|:.:|....
Mouse   868 ADVTACHLQQLNYSLGLDAPLCEGTAPTCSFPEYFVGNVLLSLLASSVFLHISSIGKLAMTFILG 932

  Fly   752 VAYLVI--------VFFQYSFIF-EHSATTT---------PFM-KAELAHCLRVCMML--LTMYA 795
            ..|||:        :|..|..:. .|...::         |.: :..|.:...|.:::  |.:|.
Mouse   933 FTYLVLLLLGPPAAIFDNYDLLLGVHGLASSNETFDGLDCPAVGRVALKYMTPVILLVFALALYL 997

  Fly   796 KERQSEFNTKINFKINQDLQGKQKAADITNKSIIILLTNILPSHVVEVYL-DSVANHELYYENYK 859
            ..:|.|...:::|.......|:::..:........||.||||..|...:| ....|.||||::.:
Mouse   998 HAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCE 1062

  Fly   860 MVSVMFAMLINFQ---MDLPS-------LRVLNDIITEFDRLLNAYKEYYVVEKIKVVGCTYMAA 914
            .|:||||.:.||.   ::|.:       ||:||:||.:||.:::. :.:..:||||.:|.|||||
Mouse  1063 CVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISE-ERFRQLEKIKTIGSTYMAA 1126

  Fly   915 CGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAFIMTTFALDLMRVLSVCNKAY 979
            .||:                :|..:||         ...|   ...:..:|:.||..:...|
Mouse  1127 SGLN----------------ASTYDQV---------GRSH---ITALADYAMRLMEQMKHIN--- 1160

  Fly   980 AGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTQETAN 1044
                 :.:.:..::.||::.|.::|||:||.:|.||||||.||::|||:|||:|..|.||.:...
Mouse  1161 -----EHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQ 1220

  Fly  1045 IL--EQFDIMCMYRGMTFVKGRGEIPTYFV 1072
            :|  :.:.:.|  ||:..|||:||:.|||:
Mouse  1221 VLAAKGYQLEC--RGVVKVKGKGEMTTYFL 1248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AcyC	85..452	CDD:441717	116/372 (31%)
		Nucleotidyl_cyc_III	298..484	CDD:448371	80/186 (43%)
		Nucleotidyl_cyc_III	853..1072	CDD:448371	77/230 (33%)
Adcy6	XP_006520366.3	AC_N	83..454	CDD:318454	58/252 (23%)
		Guanylate_cyc	456..640	CDD:425528	79/185 (43%)
		Adcy_cons_dom	668..755	CDD:461877	16/86 (19%)
		Guanylate_cyc	1056..1250	CDD:425528	78/232 (34%)