DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ACXB and ADCY9

DIOPT Version :9

Sequence 1:NP_620474.2 Gene:ACXB / 53427 FlyBaseID:FBgn0040509 Length:1114 Species:Drosophila melanogaster
Sequence 2:XP_005255136.1 Gene:ADCY9 / 115 HGNCID:240 Length:1372 Species:Homo sapiens


Alignment Length:1296 Identity:286/1296 - (22%)
Similarity:490/1296 - (37%) Gaps:370/1296 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 RLWERGYLKAKCKELCLEEEYKKYQIRLMISYLTVFFPLFIFVVVGCELCPWIFS--EQKKLIYY 82
            |.|:..:.....:|.|||..:.:.|.|..       :.|| ::...|.|....|:  .:.:||..
Human    89 RWWDPKFDSVNLEEACLERCFPQTQRRFR-------YALF-YIGFACLLWSIYFAVHMRSRLIVM 145

  Fly    83 ESLTAIVVLVAVPGILSINFFESFVLRHRW------IMVFSSILSAYIVVLVDIFQILVFHFKYH 141
            .:.....:||.| |.....|.:.:...:.|      ::||:..|:|.       ||:|.      
Human   146 VAPALCFLLVCV-GFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQ-------FQVLT------ 196

  Fly   142 WPLNTLYD-------------------VFVLCMIYMFLPIPSIRGAALLATSVSLMYIGLFIYFL 187
             |::...|                   .|.:|:..:||....:.....|:..:.:.|..||..| 
Human   197 -PVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETF- 259

  Fly   188 KSDDEDISEVVHDLDTIC-----VDIFHY--LGFNLM-------GIFFRIMNDTMVRSSFLDRHQ 238
                     ..|..|..|     ....|:  |...|:       |:...:|:....||:||...|
Human   260 ---------GYHFRDEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQ 315

  Fly   239 FLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSIKERIMLSETDSDRIVVNA-RRTENFMAIQI 302
            .:.....|...:..:..::.|::|..||..:.:...|.   ||....|...:: :..:...:||.
Human   316 SIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEE---SENSVKRHATSSPKNRKKKSSIQK 377

  Fly   303 HP------------DVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLG 355
            .|            :||||:||:|.:|.::...:...||.:|:||:||||......|.::|..||
Human   378 APIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLG 442

  Fly   356 DCYYCVAGLGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQY 420
            ||||||||..|...|||...:.:|:.||..|::....:...::||:|||:||:|.|::|..:.::
Human   443 DCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKF 507

  Fly   421 DIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPG---TEVAQSDPILQKQPMTTYLL 482
            |:|..||::||.:|..|..|.||:|..|...|: ..|.:..|   ..:.||....|.:.:.|||:
Human   508 DVWSNDVNLANLMEQLGVAGKVHISEATAKYLD-DRYEMEDGKVIERLGQSVVADQLKGLKTYLI 571

  Fly   483 TAAPSRNS-----------------------------------------VRSVDAVHSYAEIDI- 505
            :...::.|                                         |::.|.:.:.....| 
Human   572 SGQRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKTFDNLKTCPSCGIT 636

  Fly   506 ----NALGASRKSP--------------------------------------------ILRP--- 519
                :..||...:|                                            :|.|   
Human   637 FAPKSEAGAEGGAPQNGCQDEHKNSTKVTSSWLLFLSVPLLAHPPKASGGPNPKTQNGLLSPPQE 701

  Fly   520 -------TLMSDELREEFK----------KMPVGGFNIRS-------PCCRDNS--NDEKVNHGL 558
                   |.:.:.|:|:.:          .:|:...|||.       ...:::|  .|......:
Human   702 EKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPI 766

  Fly   559 GMFCVAFKDSSLEWSY---------LHKP-------------DFILKYSVLLAWGIGCCLIY--I 599
            ..|.:.|.|..||.||         .:.|             |..|..:|.|.....|.|.|  .
Human   767 NQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAA 831

  Fly   600 QIVNDKFTICVECIVIDMVVFTFLTSLLFISWFKKV--CWWRCVENDSRKYGRVSCKLFKIWER- 661
            .:......:.|....:.:.|.:...|:..:.:.:.|  |..|.:|                |.. 
Human   832 TVPPPPAALAVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLLE----------------WIAG 880

  Fly   662 -IQHSFVLRVTIYMSIVASYYLLISTILLNCDKNQYELDVINSKLYHYDIVTDNCFNPWVFTDMI 725
             :....:..:.:.:..:|.|..:.|         :||.::      |:.          |||...
Human   881 WLPRHCIGAILVSLPALAVYSHVTS---------EYETNI------HFP----------VFTGSA 920

  Fly   726 SLIVGVSY-TFARIPFALKMLITCCATVAYLVIVFFQYSFIFEHSATTTPF-----MKAELAHC- 783
            :||..|.| .|.::...::..:........|::::  .|...:.|..|:|.     ..:|...| 
Human   921 ALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLY--VSLCPDSSVLTSPLDAVQNFSSERNPCN 983

  Fly   784 -------------------LRVCMMLLTMYAKERQSEFNTKINF--KINQDL-----QGKQKAAD 822
                               |...::||.::...|:.|.:.::::  .:..||     |..:..||
Human   984 SSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQAD 1048

  Fly   823 ITNKSIIILLTNILPSHVVEVYLDSVANHELYYENYKMVSVMFAMLINF--------QMDLPSLR 879
                   .||.||:|.||.|    .:...:.|.:|:....|:||.::||        :......|
Human  1049 -------WLLRNIIPYHVAE----QLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECYR 1102

  Fly   880 VLNDIITEFDRLLNAYKEYYVVEKIKVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYR 944
            |||::|.:||.||:. .:|..:||||.:|.|||||.||:...|:.       .|:..|..|:|:.
Human  1103 VLNELIGDFDELLSK-PDYSSIEKIKTIGATYMAASGLNTAQAQD-------GSHPQEHLQILFE 1159

  Fly   945 KESKGTENDHDEVAFIMTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGA 1009
                               ||.::|||:...|.......|       ::.:|.:.|.:.|||:|.
Human  1160 -------------------FAKEMMRVVDDFNNNMLWFNF-------KLRVGFNHGPLTAGVIGT 1198

  Fly  1010 SQPHYDIWGNPVNMASRMESTGLPGHIHVTQETANILEQFDIMCMYRGMTFVKGRGEIPTY 1070
            ::..|||||:.||:||||::||:...|.|::|:..:|.:......|||...|||:|::.||
Human  1199 TKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTY 1259

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXBNP_620474.2 AC_N <36..276 CDD:292831 53/280 (19%)
CYCc 249..459 CDD:214485 73/222 (33%)
Nucleotidyl_cyc_III 298..484 CDD:299850 72/200 (36%)
CYCc 825..1047 CDD:214485 71/229 (31%)
Nucleotidyl_cyc_III 853..1072 CDD:299850 73/226 (32%)
ADCY9XP_005255136.1 DUF2339 <118..>301 CDD:287113 38/208 (18%)
CYCc 326..544 CDD:214485 72/221 (33%)
Guanylate_cyc 385..573 CDD:278633 69/188 (37%)
CYCc 1043..1243 CDD:214485 74/244 (30%)
Guanylate_cyc 1069..1260 CDD:278633 73/225 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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