DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ACXB and ADCY8

DIOPT Version :9

Sequence 1:NP_620474.2 Gene:ACXB / 53427 FlyBaseID:FBgn0040509 Length:1114 Species:Drosophila melanogaster
Sequence 2:NP_001106.1 Gene:ADCY8 / 114 HGNCID:239 Length:1251 Species:Homo sapiens


Alignment Length:1154 Identity:329/1154 - (28%)
Similarity:524/1154 - (45%) Gaps:228/1154 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 ERLWERGYLKAKCKELCLEEEYKKYQIRLMISYLTVFFPLFIFVV-VGCELCPWIFSEQKKLIYY 82
            |||::|.:|..:.|.            .::::.|.|...|.:.|: :.....|   .:..|.|..
Human   167 ERLYQRYFLGQRRKS------------EVVMNVLDVLTKLTLLVLHLSLASAP---MDPLKGILL 216

  Fly    83 ESLTAIVVLVAVPGILSINFFESFVLRH----RWIMVFSSILSAYI--VVLVDIFQILVFHFKYH 141
            ...|.|.|::....::..:......|::    .|:.:.:.||:|.:  .:|.|            
Human   217 GFFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLGYGLLGD------------ 269

  Fly   142 WPLNTLYDVFVLCMIYMFLPIPSIRGAALLATSVSLMYIGLFIYFLKSDDEDISEVVHDLDTICV 206
               ...|.:|.|...|..||:| :..|.|.....||:.:.|.:...:.....|::||       .
Human   270 ---GIGYVLFTLFATYSMLPLP-LTWAILAGLGTSLLQVILQVVIPRLAVISINQVV-------A 323

  Fly   207 DIFHYLGFNLMGIFFRIMNDTMVRSSFLDRHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQ 271
            ....::..|..|||...::|...|.:||:..:.::..:.|....|::..|:.|:||         
Human   324 QAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLP--------- 379

  Fly   272 SIKERIMLSETDSDRIVVNARRTEN-FMAIQIH--PDVSILYADVVNYTHLTTTLTVEKLVKVLH 333
                |.::.|..:|...|.....:: |..|.||  .:||||:|||..:|:|:|||:.::||::|:
Human   380 ----RFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLN 440

  Fly   334 DLYGRFDMAASTFKVQRIKFLGDCYYCVAGLGEADPDHARMAVSLGISMIANIQEVRAHRALDID 398
            :|:.|||..|......|||.||||||||:||.|...|||...|.:|:|||..|:.||:....|:|
Human   441 ELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVD 505

  Fly   399 MRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGT 463
            ||||:|||::|.||:|..|.|:|:|..||||||:||:.|.||.:|:|..||..|| .:|.|..| 
Human   506 MRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLN-GDYNVEEG- 568

  Fly   464 EVAQSDPILQKQPMTTYL-------LTAAPS---RNSVRSVDAVHSYA---------EIDI---- 505
            ...:.:..|:|..:.|||       |.:.|.   :.||.|.|..:|.|         |:..    
Human   569 HGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIV 633

  Fly   506 ---NALGA-SRKSPILRPTLMSDELR-----EEFKKMPVGGFNIRSPCCRDNSNDEKVNHGLGMF 561
               |.|.| :|.|..|.|..::..|.     ||..|......::|       |.|:.....:..|
Human   634 GKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLR-------SGDKLRREHIKPF 691

  Fly   562 CVAFKDSSLEWSYLHKPDFILKYSVLLAWGIGCCLIYIQIVNDKFTICVECIVIDMVV-FTFL-- 623
            .:.|||||||..|....|.:.|.:::.|:.:   |::|..:.   ::.....|:.|.: |:.|  
Human   692 SLMFKDSSLEHKYSQMRDEVFKSNLVCAFIV---LLFITAIQ---SLLPSSRVMPMTIQFSILIM 750

  Fly   624 --TSLLFISW----------FKKVCWWRCVENDSRKYGRVSCKLFKIWERIQHSFVLR-VTIYMS 675
              ::|:.|:.          .:|.|.|                       |..:::.| |.|:.|
Human   751 LHSALVLITTAEDYKCLPLILRKTCCW-----------------------INETYLARNVIIFAS 792

  Fly   676 IVASYYLLISTILLNCDKNQYELDVINSKLYHYDIVTDNCFNP--WVFTDMISLIVGVSYTFARI 738
            |:.::...|..||. ||.:: .:.:.|.......:.||.|..|  :|||.:::::  ....|.|:
Human   793 ILINFLGAILNILW-CDFDK-SIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMV--TCAVFLRL 853

  Fly   739 PFALKMLITCCATVAYLVIVFFQYSFIF------EHSATTTPFMKAELAHCLRVCMMLLTMYAKE 797
            ...||:.:.......|.::....|:.:|      .||.  ..|:..:....|.:.|.||.::...
Human   854 NSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSG--EDFLGTKEVSLLLMAMFLLAVFYHG 916

  Fly   798 RQSEFNTKINFKINQDLQGKQKAADIT-----NKSIIILLTNILPSHVVEVYLDSVA-NHELYYE 856
            :|.|:..:::|...  :|.|::..::.     |::   :|.|||||||...:|:... |.|||.:
Human   917 QQLEYTARLDFLWR--VQAKEEINEMKELREHNEN---MLRNILPSHVARHFLEKDRDNEELYSQ 976

  Fly   857 NYKMVSVMFAMLINF----------QMDLPSLRVLNDIITEFDRLLNAYKEYYVVEKIKVVGCTY 911
            :|..|.||||.:..|          ...:..||:||:||.:||.||.. ..:..:||||.:|.||
Human   977 SYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGE-DRFQDIEKIKTIGSTY 1040

  Fly   912 MAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAFI--MTTFALDLMRVLSV 974
            ||..||                 |.|.:|.            .|:...:  :..|:|.|...:..
Human  1041 MAVSGL-----------------SPEKQQC------------EDKWGHLCALADFSLALTESIQE 1076

  Fly   975 CNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHVT 1039
            .||        .:.:..|:.||||.|.::|||:||.:|.|||||..||:||||:|||:.|.|.|.
Human  1077 INK--------HSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVP 1133

  Fly  1040 QETANILEQFDIMCMYRGMTFVKG----RGEIPTYFV--GIDDNLKFLP 1082
            :||..||:.......|||..:|||    .|:|.|||:  .:..|...||
Human  1134 EETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILP 1182

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXBNP_620474.2 AC_N <36..276 CDD:292831 46/246 (19%)
CYCc 249..459 CDD:214485 93/212 (44%)
Nucleotidyl_cyc_III 298..484 CDD:299850 91/194 (47%)
CYCc 825..1047 CDD:214485 83/234 (35%)
Nucleotidyl_cyc_III 853..1072 CDD:299850 82/234 (35%)
ADCY8NP_001106.1 Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..182 6/26 (23%)
Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..109
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 38..40
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 49..51
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 50..92
AC_N <161..400 CDD:292831 56/283 (20%)
CYCc 366..564 CDD:214485 92/211 (44%)
Guanylate_cyc 405..589 CDD:278633 90/185 (49%)
DUF1053 617..711 CDD:283888 25/100 (25%)
CYCc 944..1148 CDD:214485 84/244 (34%)
Guanylate_cyc 973..1172 CDD:278633 83/236 (35%)
Involved in CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 1109..1251 34/74 (46%)
Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250|UniProtKB:P40146 1200..1215
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1223..1251
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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