DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXB and ADCY7

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	XP_011521137.1	Gene:	ADCY7 / 113	HGNCID:	238	Length:	1086	Species:	Homo sapiens

Alignment Length:	1176	Identity:	325/1176 - (27%)
Similarity:	521/1176 - (44%)	Gaps:	252/1176 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 YKKYQIR-----LMISYLTVFFPLFIFVVVGCELCPWIFSEQKKLIYYESLTAIVVLVAVPGILS 99
            |:|||:.     |:::.|.|.....:.:::      ..||:.....:...|....:::||...||
Human    22 YEKYQLTSQHGPLLLTLLLVAATACVALII------IAFSQGDPSRHQAILGMAFLVLAVFAALS 80

  Fly   100 INFFESFVLRHRWIMVFSSILSAYIVVLVDIFQILVFHFKYHWPL------NTLYDVFVLCMIYM 158
            :..:...:|| ||:...:.:..|.:|.|   ..:|||.   .|..      ...:.:|::.::|.
Human    81 VLMYVECLLR-RWLRALALLTWACLVAL---GYVLVFD---AWTKAACAWEQVPFFLFIVFVVYT 138

  Fly   159 FLPIPSIRGA---ALLATSVSLMYIGLFIYFLKSDDEDISEVVHDLDTICVDIFHYLGFNLMGIF 220
            .||. |:|||   ..::|:..|:.:|..:....:....:.     |..:...:....| ||.|.|
Human   139 LLPF-SMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVG-----LQLLANAVIFLCG-NLTGAF 196

  Fly   221 FRIMNDTMVRSSFLDRHQFLKEEMWLR-QARQQESMLLDSILPPQIAKPIQQSIKERIMLSETDS 284
            .:.......|..|....:.::....|| :.||||::|| |:||..|:..::.:|.||:   :...
Human   197 HKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLL-SVLPAHISMGMKLAIIERL---KEHG 257

  Fly   285 DRIVVNARRTENFMAIQI--HPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFK 347
            ||   ......||.::.:  |.:|||||||:|.:|.|.:..:.::||.||::|:|:||..|...:
Human   258 DR---RCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANE 319

  Fly   348 VQRIKFLGDCYYCVAGLGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGV 412
            ..|||.||||||||:||..:.|.|||..|.:|:.|...|::||....:||:||:|:|||.:|.||
Human   320 CMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGV 384

  Fly   413 IGQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPM 477
            ||..|.|||:|..||.:|||:||.|.||.||::..||..|:.| |.|..| ...|.||.|::..:
Human   385 IGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKA-YEVEDG-HGQQRDPYLKEMNI 447

  Fly   478 TTYLL---------------------TAAPSRNSVRSVDAVHSYAEIDINALGASRKSPIL--RP 519
            .|||:                     .|...|.|||....:.|:        ||:|....|  |.
Human   448 RTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRASVRMTRYLESW--------GAARPFAHLNHRE 504

  Fly   520 TLMSDE-----------LREEFKKMP----------------------VGGFNIRSPCCRDNSND 551
            ::.|.|           :.:..::.|                      :.|.:...|||  :.:|
Human   505 SVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRSEDDSYDDEMLSAIEGLSSTRPCC--SKSD 567

  Fly   552 EKVNHGLGMFCVAFKDSSLEWSYLHKPDFILKYSVLLAWGIGCCLIYIQI----------VNDKF 606
            :....|     ..|.:...|..|...|....::....|..|..|::.:.:          |:...
Human   568 DFYTFG-----SIFLEKGFEREYRLAPIPRARHDFACASLIFVCILLVHVLLMPRTAALGVSFGL 627

  Fly   607 TICVECIVIDMVVFTFLTSLLFISWFKKVCWWRCVENDSRKYGRVSCKLFKIWERIQHSFVLRVT 671
            ..||..:|:         .|.|.:.|.:.|..|..             |..|.||::...:||:|
Human   628 VACVLGLVL---------GLCFATKFSRCCPARGT-------------LCTISERVETQPLLRLT 670

  Fly   672 IYMSIVASYYLLISTILLNCDKNQY---ELDVIN--------SK-------LYHYDIVTDNCFNP 718
            :.:..:.|   |::..::|.....:   ||.|.|        ||       |.:|   |.:|...
Human   671 LAVLTIGS---LLTVAIINLPLMPFQVPELPVGNETGLLAASSKTRALCEPLPYY---TCSCVLG 729

  Fly   719 WVFTDMISLIVGVSYTFARIPFALKMLITCCATVAYLVIVFFQYS-------------FIFEHSA 770
            ::...:          |.|:....|:::...|.|||||:  |..|             .:.:.:.
Human   730 FIACSV----------FLRMSLEPKVVLLTVALVAYLVL--FNLSPCWQWDCCGQGLGNLTKPNG 782

  Fly   771 TT--TPFMK-AELAHCLRVCMML--LTMYAKERQSEFNTKINFKINQDLQGKQKAADITNKSIII 830
            ||  ||... .:|.......::|  :|:....||.::..:::....:..:.:.:..:.......:
Human   783 TTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRL 847

  Fly   831 LLTNILPSHVVEVYLDSVANHELYYENYKMVSVMFAMLINFQM----------DLPSLRVLNDII 885
            ||.|:||:||...::....|.:.|:::|..|.||||.:.:|::          .|..||:||:||
Human   848 LLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEII 912

  Fly   886 TEFDRLLNAYKEYYVVEKIKVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGT 950
            .:||.||...| :..|||||.:|.|||||.||                      .|....|::..
Human   913 ADFDELLLKPK-FSGVEKIKTIGSTYMAAAGL----------------------SVASGHENQEL 954

  Fly   951 ENDHDEVAFIMTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYD 1015
            |..|..:. :|..|::.||..|...|:        .:.::..:.:||:.|.::|||:||.:|.||
Human   955 ERQHAHIG-VMVEFSIALMSKLDGINR--------HSFNSFRLRVGINHGPVIAGVIGARKPQYD 1010

  Fly  1016 IWGNPVNMASRMESTGLPGHI------HVTQETANILEQFDIMCMYRGMTFVKGRGEIPTYFVGI 1074
            ||||.||:||||||||..|.|      .||:||..||:.....|..||:..|||:||:.|||| .
Human  1011 IWGNTVNVASRMESTGELGKIQVSLPFQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFV-C 1074

  Fly  1075 DDNLKF 1080
            .|..||
Human  1075 TDTAKF 1080

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	57/250 (23%)
		CYCc	249..459	CDD:214485	95/211 (45%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	87/208 (42%)
		CYCc	825..1047	CDD:214485	83/237 (35%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	86/234 (37%)
ADCY7	XP_011521137.1	AC_N	<73..249	CDD:292831	46/190 (24%)
		CYCc	224..429	CDD:214485	94/212 (44%)
		Guanylate_cyc	270..432	CDD:278633	79/162 (49%)
		DUF1053	485..592	CDD:283888	19/121 (16%)
		CYCc	848..1052	CDD:214485	84/235 (36%)
		Guanylate_cyc	871..1073	CDD:278633	86/233 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020