Protein Alignment ACXB and ADCY6

DIOPT Version :9

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: NP_001377760.1
• Gene: ADCY6 / 112
• HGNCID: 237
• Length: 1168
• Species: Homo sapiens
• Alignment Length: 1138
• Identity: 288/1138 - (25%)
• Similarity: 502/1138 - (44%)
• Gaps: 212/1138 - (18%)

  Fly    36 LEEEYKKYQIRLMISYLTVFFPLFIFVVVGCELCPWIFSEQKKLIYYESLTAIVVLVAVPGILSI 100
            ||..|::|..::..|.||:.  :.:.|::...|..:..:..:....|.:|.|....:.| |::.:
Human   136 LERLYQRYFFQMNQSSLTLL--MAVLVLLTAVLLAFHAAPARPQPAYVALLACAAALFV-GLMVV 197

  Fly   101 NFFESFVLRHRWIM--VFSSILSAYIVVLVDIFQILVFHFKYHWPLNTLY-DVFVLCMIYMFLPI 162
            ....||.....|::  |...||:|     |.:...|....:.  |...|: .||.:.:.|..|||
Human   198 CNRHSFRQDSMWVVSYVVLGILAA-----VQVGGALAADPRS--PSAGLWCPVFFVYIAYTLLPI 255

  Fly   163 PSIRGAALLATSVSLMYIGLFIYFLKSDDEDISEVVHDLDTICVDIFHYLGFNLMGIFFRIMNDT 227
             .:|.|.|....:|.::: :..:.|...|..:.:      .:..::..:|..|::||......:.
Human   256 -RMRAAVLSGLGLSTLHL-ILAWQLNRGDAFLWK------QLGANVLLFLCTNVIGICTHYPAEV 312

  Fly   228 MVRSSFLDRHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSI---KERIMLSETDSDRIVV 289
            ..|.:|.:...:::..:.|:...:|:..||.|:||..:|..:::.|   ||.:|..:
Human   313 SQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHK-------- 369

  Fly   290 NARRTENFMAIQIHPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFL 354
                    :.||.|.:||||:||:..:|.|.:..|.::||..|::|:.|||..|:.....|||.|
Human   370 --------IYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKIL 426

  Fly   355 GDCYYCVAGLGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQ 419
            |||||||:||.||..|||...|.:|:.||..|..||....::::||:|:|||.:..||:|..|.|
Human   427 GDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQ 491

  Fly   420 YDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPMTTYLLTA 484
            :|:|..||.:||.:||.|:.|.:|::..||..|| .:|.|.|| ...:.:..|::|.:.|:|:..
Human   492 FDVWSNDVTLANHMEAGGRAGRIHITRATLQYLN-GDYEVEPG-RGGERNAYLKEQHIETFLILG 554

  Fly   485 A------------------------------PSRNSVRSVDAVHSYAEIDINALGASRKSPILRP 519
            |                              |.|...|:.|: .::.::.|:  .:|:.:...:.
Human   555 ASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDS-KAFRQMGID--DSSKDNRGTQD 616

  Fly   520 TLMSDELREEFKKMPVGGFNIRSPCCRDNSNDEKVNHGLGMFCVAFKDSSLEWSYLHKPDFILKY 584
            .|..::..:||....:...:|      |....:.|..    |.:.|:...||..|..|.|.....
Human   617 ALNPEDEVDEFLSRAIDARSI------DQLRKDHVRR----FLLTFQREDLEKKYSRKVDPRFGA 671

  Fly   585 SVLLAWGIGCCLIYIQIV---NDKFTICVECIVIDMVVFTFLTSLLFISWFKKVCWWRCVENDSR 646
            .|..|..:.|.:.:||::   :....:.:...:..:::.|.|...::
Human   672 YVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVY------------------ 718

  Fly   647 KYGRVSC-KLF-KIWERIQHSFVLR------------VTIYMSIVASYYLLISTILLNCDKNQYE 697
                 || .|| |..:|:..|.|..            :.::.|.:|:.:....|.:.:|......
Human   719 -----SCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLN 778

  Fly   698 LDVINSKLYH-----YDIVTD---------NCFNPWVFTDMISLIVGVSYTFARIPFALKMLITC 748
            |...:....|     |.:..|         .|..|..|...:.|.:..|..|..|....|:.:..
Human   779 LTPADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLAMIF 843

  Fly   749 CATVAYLVI--------VFFQYSFIF-EH--SATTTPFMKAELAHCLRVCMMLLT---------- 792
            ...:.|||:        :|..|..:. .|  :::...|...:.....||.:..:|
Human   844 VLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLVFALA 908

  Fly   793 MYAKERQSEFNTKINFKINQDLQGKQKAADITNKSIIILLTNILPSHVVEVYL-DSVANHELYYE 856
            :|...:|.|...:::|.......|:::..:........||.||||..|...:| ....|.||||:
Human   909 LYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQ 973

  Fly   857 NYKMVSVMFAMLINFQ---MDLPS-------LRVLNDIITEFDRLLNAYKEYYVVEKIKVVGCTY 911
            :.:.|:||||.:.||.   ::|.:       ||:||:||.:||.:::. :.:..:||||.:|.||
Human   974 SCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISE-ERFRQLEKIKTIGSTY 1037

  Fly   912 MAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAFIMTTFALDLMRVLSVCN 976
            |||.||:                :|..:||         ...|   ...:..:|:.||..:...|
Human  1038 MAASGLN----------------ASTYDQV---------GRSH---ITALADYAMRLMEQMKHIN 1074

  Fly   977 KAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTQE 1041
                    :.:.:..::.||::.|.::|||:||.:|.||||||.||::|||:|||:|..|.||.:
Human  1075 --------EHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTD 1131

  Fly  1042 TANIL--EQFDIMCMYRGMTFVKGRGEIPTYFV 1072
            ...:|  :.:.:.|  ||:..|||:||:.|||:
Human  1132 LYQVLAAKGYQLEC--RGVVKVKGKGEMTTYFL 1162

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	53/245 (22%)
		CYCc	249..459	CDD:214485	83/212 (39%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	79/185 (43%)
		CYCc	825..1047	CDD:214485	77/234 (33%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	77/230 (33%)
ADCY6	NP_001377760.1	AC_N	<16..368	CDD:318454	55/249 (22%)
		Guanylate_cyc	370..554	CDD:306677	79/185 (43%)
		DUF1053	582..668	CDD:399378	19/98 (19%)
		Guanylate_cyc	970..1164	CDD:306677	78/232 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910