Protein Alignment ACXB and ADCY3

DIOPT Version :9

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: XP_011530791.1
• Gene: ADCY3 / 109
• HGNCID: 234
• Length: 1186
• Species: Homo sapiens
• Alignment Length: 1252
• Identity: 329/1252 - (26%)
• Similarity: 544/1252 - (43%)
• Gaps: 306/1252 - (24%)

  Fly     9 PRKCYLDYTDERLWERGYLKAKCKELCLEEEYKKYQIRLMISYLTVFFPLF-IFVVVGCELCPWI 72
            ||...|.:..|.|..            |.:.|.|.|....:..|.||..|| .:|||   :|..:
Human    50 PRFMRLTFVPESLEN------------LYQTYFKRQRHETLLVLVVFAALFDCYVVV---MCAVV 99

  Fly    73 FSEQKKLIYYESLTAIVVLVAVPGILSINFFESFVLRHRWIM-------VFSSILSAYIVVLVDI 130
            ||..|           :..:||.||..:.....|||..:.::       |...:|  ::::...|
Human   100 FSSDK-----------LASLAVAGIGLVLDIILFVLCKKGLLPDRVTRRVLPYVL--WLLITAQI 151

  Fly   131 FQILVFHF-KYHWPLNTL-YDVFVLCMIYMFLP--IPSIRGAALLATSVSLMYIGLFIYFLKSDD 191
            |..|..:| :.|...:|: :.||.:...::.||  :..|...::::..|..:.:|:.:  .:...
Human   152 FSYLGLNFARAHAASDTVGWQVFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTV--AQQQQ 214

  Fly   192 EDISEVVHDLDTICVDIFHYLGFNLMGIFFRIMNDTMVRSSFLDRHQFLKEEMWLRQARQQESML 256
            |:: :.:..|..|..::|.||....:||....|.|...|.:||:..|.|:.:|.|.:..||:..|
Human   215 EEL-KGMQLLREILANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENL 278

  Fly   257 LDSILPPQIAKPIQQSIKERIMLSETDSDRIVVNARRTENFMAIQIHPDVSILYADVVNYTHLTT 321
            :.||||..:|..:.:.:|:    .|:..|      ::..|.|.:..|.:||||:||:|.:|.|::
Human   279 MLSILPKHVADEMLKDMKK----DESQKD------QQQFNTMYMYRHENVSILFADIVGFTQLSS 333

  Fly   322 TLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVAGLGEADPDHARMAVSLGISMIANI 386
            ..:.::|||:|::|:.|||..|:.:...|||.|||||||:.||.:...|||..::.:|::|:..|
Human   334 ACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAI 398

  Fly   387 QEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEATGKPG----------- 440
            ..||......:|||:|||:||:|.||:||.:.|||:|..||.:||::||.|.||
Human   399 SYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGGSKIEERLYSC 463

  Fly   441 -----------YVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPMTTYLLTAAPSRNSVRSV 494
                       .||:|..|:..|. .|:.|.||...::.| .|:::.:.|||:.|  |:..|:..
Human   464 VVAPTLRLRWERVHISQSTMDCLK-GEFDVEPGDGGSRCD-YLEEKGIETYLIIA--SKPEVKKT 524

  Fly   495 DAVHSYAEIDINAL--GASRKSPILRPTLM--------------SDELREE---------FKKMP 534
            ...:.   ::.:||  ||...|....|.|:              :.|..||         ...:|
Human   525 ATQNG---LNGSALPNGAPASSKSSSPALIETKEPNGSAHSSGSTSEKPEEQDAQLFPTTLSHLP 586

  Fly   535 ----VGGFNIRSPC----------------CRDNSNDE-KVNHGLG------------------M 560
                :.|....:|.                ..|.|.|| ::|..|.                  :
Human   587 HSRCLPGSQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFL 651

  Fly   561 FCVAFKDSSLEWSYLHKPD------FILKYSVLLAWGIGCCLIYIQIVNDKF------TICVECI 613
            ..:.|.|..:|..|..:.:      |.....|||      |...::|:.|.:      |..|..|
Human   652 LSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLL------CTALVEILIDPWLMTNYVTFMVGEI 710

  Fly   614 VIDMVVFTFLTSLL----------FISWFKKVCWWRCVENDSRKYGRVSCKLFKIWERIQHSFVL 668
            ::.::....|.::.          |.:|..:..|.|                 ..|
Human   711 LLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRWAR-----------------NTW--------- 749

  Fly   669 RVTIYMSIVASYYLLISTI--LLNCDKNQY-----------ELD---VINSKLYHYDIVTDNCFN 717
                  :::|.:.|:::.:  :|:|  .||           |.:   :.|.|.|:|..|
Human   750 ------AMLAIFILVMANVVDMLSC--LQYYTGPSNATAGMETEGSCLENPKYYNYVAV------ 800

  Fly   718 PWVFTDMISLIVGVSYTFARIPFALKMLITCCATVAYLVI-----VFFQYSF--IFEH------- 768
                   :|||..:..........|.:::.....||.:.:     ||.:|..  ..||
Human   801 -------LSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDEYDHKRFREHDLPMVAL 858

  Fly   769 ------------SATTTPFMKAELAHCLRVCMMLLTMYAKERQSE--FNTKINFKINQDLQGKQK 819
                        :.:..|.:.::.:..:.|.:|:|:.|...|..|  ..|...:||....| |::
Human   859 EQMQGFNPGLNGTDSRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQ-KER 922

  Fly   820 AADIT--NKSIIILLTNILPSHVVEVYLDS-VANHELYYENYKMVSVMFAMLINF---------- 871
            ..::.  |::   |:||:||.||...:|.| ..:.|||.:.|..:.||||.|.||
Human   923 VYEMRRWNEA---LVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESIN 984

  Fly   872 QMDLPSLRVLNDIITEFDRLLNAYKEYYVVEKIKVVGCTYMAACGLDFTLAKSKFGSRTHASYSS 936
            ...:..||.||:||::||.||:..| :.|:.|||.:|.|||||.|:...:..:.|.|.
Human   985 NGGIECLRFLNEIISDFDSLLDNPK-FRVITKIKTIGSTYMAASGVTPDVNTNGFASS------- 1041

  Fly   937 ELEQVLYRKESKGTENDHDEVAFIMTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIGISTGE 1001
                   .||.| :|.:..:....:..|||.:...|:..|        :::.:...:.||::.|.
Human  1042 -------NKEDK-SERERWQHLADLADFALAMKDTLTNIN--------NQSFNNFMLRIGMNKGG 1090

  Fly  1002 IMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTQETANILEQFDIMCMYRGMTFVKGRGE 1066
            ::|||:||.:||||||||.||:||||||||:.|:|.|.:||..||.::....:.||..||||:||
Human  1091 VLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGE 1155

  Fly  1067 IPTYFVGIDDNLKFLPS 1083
            :.|:|:...|.|...|:
Human  1156 LLTFFLKGRDKLATFPN 1172

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	64/251 (25%)
		CYCc	249..459	CDD:214485	84/231 (36%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	80/207 (39%)
		CYCc	825..1047	CDD:214485	86/232 (37%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	85/228 (37%)
ADCY3	XP_011530791.1	AC_N	<44..303	CDD:292831	70/287 (24%)
		CYCc	273..490	CDD:214485	83/227 (37%)
		Guanylate_cyc	310..516	CDD:278633	80/207 (39%)
		CYCc	925..1143	CDD:214485	87/244 (36%)
		Guanylate_cyc	956..1163	CDD:278633	86/230 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810