Protein Alignment ACXB and ADCY3

DIOPT Version :10

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: XP_011530791.1
• Gene: ADCY3 / 109
• HGNCID: 234
• Length: 1186
• Species: Homo sapiens
• Alignment Length: 1252
• Identity: 329/1252 - (26%)
• Similarity: 544/1252 - (43%)
• Gaps: 306/1252 - (24%)

  Fly     9 PRKCYLDYTDERLWERGYLKAKCKELCLEEEYKKYQIRLMISYLTVFFPLF-IFVVVGCELCPWI 72
            ||...|.:..|.|..            |.:.|.|.|....:..|.||..|| .:|||   :|..:
Human    50 PRFMRLTFVPESLEN------------LYQTYFKRQRHETLLVLVVFAALFDCYVVV---MCAVV 99

  Fly    73 FSEQKKLIYYESLTAIVVLVAVPGILSINFFESFVLRHRWIM-------VFSSILSAYIVVLVDI 130
            ||..|           :..:||.||..:.....|||..:.::       |...:|  ::::...|
Human   100 FSSDK-----------LASLAVAGIGLVLDIILFVLCKKGLLPDRVTRRVLPYVL--WLLITAQI 151

  Fly   131 FQILVFHF-KYHWPLNTL-YDVFVLCMIYMFLP--IPSIRGAALLATSVSLMYIGLFIYFLKSDD 191
            |..|..:| :.|...:|: :.||.:...::.||  :..|...::::..|..:.:|:.:  .:...
Human   152 FSYLGLNFARAHAASDTVGWQVFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTV--AQQQQ 214

  Fly   192 EDISEVVHDLDTICVDIFHYLGFNLMGIFFRIMNDTMVRSSFLDRHQFLKEEMWLRQARQQESML 256
            |:: :.:..|..|..::|.||....:||....|.|...|.:||:..|.|:.:|.|.:..||:..|
Human   215 EEL-KGMQLLREILANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENL 278

  Fly   257 LDSILPPQIAKPIQQSIKERIMLSETDSDRIVVNARRTENFMAIQIHPDVSILYADVVNYTHLTT 321
            :.||||..:|..:.:.:|:    .|:..|      ::..|.|.:..|.:||||:||:|.:|.|::
Human   279 MLSILPKHVADEMLKDMKK----DESQKD------QQQFNTMYMYRHENVSILFADIVGFTQLSS 333

  Fly   322 TLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVAGLGEADPDHARMAVSLGISMIANI 386
            ..:.::|||:|::|:.|||..|:.:...|||.|||||||:.||.:...|||..::.:|::|:..|
Human   334 ACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAI 398

  Fly   387 QEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEATGKPG----------- 440
            ..||......:|||:|||:||:|.||:||.:.|||:|..||.:||::||.|.||
Human   399 SYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGGSKIEERLYSC 463

  Fly   441 -----------YVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPMTTYLLTAAPSRNSVRSV 494
                       .||:|..|:..|. .|:.|.||...::.| .|:::.:.|||:.|  |:..|:..
Human   464 VVAPTLRLRWERVHISQSTMDCLK-GEFDVEPGDGGSRCD-YLEEKGIETYLIIA--SKPEVKKT 524

  Fly   495 DAVHSYAEIDINAL--GASRKSPILRPTLM--------------SDELREE---------FKKMP 534
            ...:.   ::.:||  ||...|....|.|:              :.|..||         ...:|
Human   525 ATQNG---LNGSALPNGAPASSKSSSPALIETKEPNGSAHSSGSTSEKPEEQDAQLFPTTLSHLP 586

  Fly   535 ----VGGFNIRSPC----------------CRDNSNDE-KVNHGLG------------------M 560
                :.|....:|.                ..|.|.|| ::|..|.                  :
Human   587 HSRCLPGSQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFL 651

  Fly   561 FCVAFKDSSLEWSYLHKPD------FILKYSVLLAWGIGCCLIYIQIVNDKF------TICVECI 613
            ..:.|.|..:|..|..:.:      |.....|||      |...::|:.|.:      |..|..|
Human   652 LSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLL------CTALVEILIDPWLMTNYVTFMVGEI 710

  Fly   614 VIDMVVFTFLTSLL----------FISWFKKVCWWRCVENDSRKYGRVSCKLFKIWERIQHSFVL 668
            ::.::....|.::.          |.:|..:..|.|                 ..|
Human   711 LLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRWAR-----------------NTW--------- 749

  Fly   669 RVTIYMSIVASYYLLISTI--LLNCDKNQY-----------ELD---VINSKLYHYDIVTDNCFN 717
                  :::|.:.|:::.:  :|:|  .||           |.:   :.|.|.|:|..|
Human   750 ------AMLAIFILVMANVVDMLSC--LQYYTGPSNATAGMETEGSCLENPKYYNYVAV------ 800

  Fly   718 PWVFTDMISLIVGVSYTFARIPFALKMLITCCATVAYLVI-----VFFQYSF--IFEH------- 768
                   :|||..:..........|.:::.....||.:.:     ||.:|..  ..||
Human   801 -------LSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDEYDHKRFREHDLPMVAL 858

  Fly   769 ------------SATTTPFMKAELAHCLRVCMMLLTMYAKERQSE--FNTKINFKINQDLQGKQK 819
                        :.:..|.:.::.:..:.|.:|:|:.|...|..|  ..|...:||....| |::
Human   859 EQMQGFNPGLNGTDSRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQ-KER 922

  Fly   820 AADIT--NKSIIILLTNILPSHVVEVYLDS-VANHELYYENYKMVSVMFAMLINF---------- 871
            ..::.  |::   |:||:||.||...:|.| ..:.|||.:.|..:.||||.|.||
Human   923 VYEMRRWNEA---LVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESIN 984

  Fly   872 QMDLPSLRVLNDIITEFDRLLNAYKEYYVVEKIKVVGCTYMAACGLDFTLAKSKFGSRTHASYSS 936
            ...:..||.||:||::||.||:..| :.|:.|||.:|.|||||.|:...:..:.|.|.
Human   985 NGGIECLRFLNEIISDFDSLLDNPK-FRVITKIKTIGSTYMAASGVTPDVNTNGFASS------- 1041

  Fly   937 ELEQVLYRKESKGTENDHDEVAFIMTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIGISTGE 1001
                   .||.| :|.:..:....:..|||.:...|:..|        :::.:...:.||::.|.
Human  1042 -------NKEDK-SERERWQHLADLADFALAMKDTLTNIN--------NQSFNNFMLRIGMNKGG 1090

  Fly  1002 IMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTQETANILEQFDIMCMYRGMTFVKGRGE 1066
            ::|||:||.:||||||||.||:||||||||:.|:|.|.:||..||.::....:.||..||||:||
Human  1091 VLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGE 1155

  Fly  1067 IPTYFVGIDDNLKFLPS 1083
            :.|:|:...|.|...|:
Human  1156 LLTFFLKGRDKLATFPN 1172

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AcyC	85..452	CDD:441717	121/399 (30%)
		Nucleotidyl_cyc_III	298..484	CDD:448371	80/207 (39%)
		Nucleotidyl_cyc_III	853..1072	CDD:448371	85/228 (37%)
ADCY3	XP_011530791.1	AcyC	105..494	CDD:441717	124/404 (31%)
		Guanylate_cyc	310..516	CDD:425528	80/207 (39%)
		Guanylate_cyc	956..1163	CDD:425528	86/230 (37%)