DRSC/TRiP Functional Genomics Resources

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Protein Alignment ACXB and ADCY2

DIOPT Version :9

Sequence 1:NP_620474.2 Gene:ACXB / 53427 FlyBaseID:FBgn0040509 Length:1114 Species:Drosophila melanogaster
Sequence 2:NP_065433.2 Gene:ADCY2 / 108 HGNCID:233 Length:1091 Species:Homo sapiens


Alignment Length:1192 Identity:318/1192 - (26%)
Similarity:536/1192 - (44%) Gaps:231/1192 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 ERLWERGYLKAKCKE-------------------LCLEEEYKKYQIRLMISYLTVFFPLFIFVVV 64
            |.:..|.||:.:.:|                   .|:.:::......|:|...:....|.:|..:
Human     4 EAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFAL 68

  Fly    65 GCELCPWIFSEQKKLIYYESLTAIVVLVAVPGILSINFFESFVL------RHRWIMVFSSILSAY 123
            |.|:      |..          :..|:.||..|:| ||..|:|      ..:.:.:||.::...
Human    69 GLEV------EDH----------VAFLITVPTALAI-FFAIFILVCIESVFKKLLRLFSLVIWIC 116

  Fly   124 IVVLVDIF-----------QILVFHFKYHWPLNTLYDVFVLCMIYMFLPIPSIRG---AALLATS 174
            :|.:..:|           |:..|             :|::.::|..||. ::|.   |::|.:|
Human   117 LVAMGYLFMCFGGTVSPWDQVSFF-------------LFIIFVVYTMLPF-NMRDAIIASVLTSS 167

  Fly   175 VSLMYIGLFIYFLKSDDEDISEVVHDLDTICVDIFHYLGFNLMGIFFRIMNDTMVRSSFLDRHQF 239
            ...:.:.:.:.......|      |.:..|..::..::..||.|.:.:.:.:..::.::.|....
Human   168 SHTIVLSVCLSATPGGKE------HLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNC 226

  Fly   240 LKEEMWLR-QARQQESMLLDSILPPQIAKPIQQSIKERIMLSETDSDRIVVNARRTENF--MAIQ 301
            :|..:.|. :.||||.:|| |:||..||..::..|.:|:...:..      ....|.||  :.::
Human   227 IKSRIKLEFEKRQQERLLL-SLLPAHIAMEMKAEIIQRLQGPKAG------QMENTNNFHNLYVK 284

  Fly   302 IHPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVAGLGE 366
            .|.:|||||||:|.:|.|.:..:..:||.:|::|:|:||..|...:..|||.||||||||:||..
Human   285 RHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPI 349

  Fly   367 ADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIAN 431
            :.|:||:..|.:|:.|...|::||....:||:||:|||||.:|.||||..|.|||:|..||.:||
Human   350 SLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLAN 414

  Fly   432 RLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPMTTYL--------------- 481
            .:||.|.||.||:|..||..||.| |.|..|....: ||.|::..:.||.               
Human   415 HMEAGGVPGRVHISSVTLEHLNGA-YKVEEGDGDIR-DPYLKQHLVKTYFVINPKGERRSPQHLF 477

  Fly   482 -----LTAAPSRNSVRSVDAVHSYAEIDINALGASRKSPIL--RPTLMSDELREEFKKMPVGGFN 539
                 |..|..|.|||....:.|:        ||::....|  |.::.::..:.....:|:|..|
Human   478 RPRHTLDGAKMRASVRMTRYLESW--------GAAKPFAHLHHRDSMTTENGKISTTDVPMGQHN 534

  Fly   540 IRSPCCRDNSN----DEKVN-------------------HGLGMFCVAFKDSSLEWSYLHKPDFI 581
            .::...|..|.    :|::|                   ..:....:.|.:..||..|.......
Human   535 FQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPA 599

  Fly   582 LKYSVLLAWGIGCCLIYIQIVNDKFTICVECIVIDMVVFTFLTSLLFISWFKKVCWWRCVENDSR 646
            .||.|..|..|..|:..:||:     :..:..|:.:   :|..:.|.:::...||:...:...|:
Human   600 FKYYVTCACLIFFCIFIVQIL-----VLPKTSVLGI---SFGAAFLLLAFILFVCFAGQLLQCSK 656

  Fly   647 KYGRVSCKLFKI--------WERIQHSFVLRVTIYMSIVASYYLL----------ISTILLNCDK 693
            |...:...|.|.        |.||..:.:....|.|..|.:.:.|          .:|...:...
Human   657 KASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFSA 721

  Fly   694 NQYELDVINSK-LYHYDIVTDNCFNPWVFTDMISLIVGVSYTFARIPFALKMLITCCATVAYLVI 757
            :..::.::.:: |:         |.|:.....|..::..| .|.|:.:.|||||...|.|.|..|
Human   722 SNNQVAILRAQNLF---------FLPYFIYSCILGLISCS-VFLRVNYELKMLIMMVALVGYNTI 776

  Fly   758 VFFQYSFI--------FEHSATTTPFMKAELAHCLRVCMMLLTMYAKERQSEFNTKINFKINQDL 814
            :...::.:        ||....   :...:....:.:.:..:|:....||:|:..:::|......
Human   777 LLHTHAHVLGDYSQVLFERPGI---WKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKF 838

  Fly   815 QGKQKAADITNKSIIILLTNILPSHVVEVYL-DSVANHELYYENYKMVSVMFAMLINF------- 871
            :.:::..:.......:||.|:||:||.|.:| .|:.|.|||:::|..|.||||.:.:|       
Human   839 KKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTES 903

  Fly   872 ---QMDLPSLRVLNDIITEFDRLLNAYKEYYVVEKIKVVGCTYMAACGLDFTLAKSKFGSRTHAS 933
               :..|..||:||:||.:||.||:..| :..|||||.:|.|||||.||      |...|:.|  
Human   904 DVNKEGLECLRLLNEIIADFDDLLSKPK-FSGVEKIKTIGSTYMAATGL------SAVPSQEH-- 959

  Fly   934 YSSELEQVLYRKESKGTENDHDEVAFIMTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIGIS 998
                         |:..|..:..:. .|..||..|:..|...||        .:.:..::.:||:
Human   960 -------------SQEPERQYMHIG-TMVEFAFALVGKLDAINK--------HSFNDFKLRVGIN 1002

  Fly   999 TGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTQETANILEQFDIMCMYRGMTFVKG 1063
            .|.::|||:||.:|.||||||.||:||||:|||:...|.||:||:.:|:.....|..||:..|||
Human  1003 HGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKG 1067

  Fly  1064 RGEIPTYFVGIDDNLKFLPSNV 1085
            :|::.||||..:.:.....|||
Human  1068 KGDLKTYFVNTEMSRSLSQSNV 1089

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXBNP_620474.2 AC_N <36..276 CDD:292831 51/260 (20%)
CYCc 249..459 CDD:214485 94/211 (45%)
Nucleotidyl_cyc_III 298..484 CDD:299850 86/205 (42%)
CYCc 825..1047 CDD:214485 87/232 (38%)
Nucleotidyl_cyc_III 853..1072 CDD:299850 85/228 (37%)
ADCY2NP_065433.2 AC_N <33..260 CDD:292831 51/264 (19%)
CYCc 236..439 CDD:214485 93/210 (44%)
Guanylate_cyc 281..465 CDD:278633 85/185 (46%)
DUF1053 495..599 CDD:283888 16/111 (14%)
CYCc 848..1056 CDD:214485 88/238 (37%)
Guanylate_cyc 878..1077 CDD:278633 86/229 (38%)
Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769 905..922 7/16 (44%)
Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769 990..993 0/2 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S5262
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D181177at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45627
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
65.830

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