DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ACXB and ADCY1

DIOPT Version :9

Sequence 1:NP_620474.2 Gene:ACXB / 53427 FlyBaseID:FBgn0040509 Length:1114 Species:Drosophila melanogaster
Sequence 2:NP_066939.1 Gene:ADCY1 / 107 HGNCID:232 Length:1119 Species:Homo sapiens


Alignment Length:1116 Identity:284/1116 - (25%)
Similarity:463/1116 - (41%) Gaps:322/1116 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   113 IMVFSSILSAYIVVLVDIFQI-LVFHFKYHWPLNTLYDVFVLCMIYMFLPIPSIRGAA------- 169
            ::|.:::.|..:..|..:.|: |:|...:         ..:.|...:..|.....|||       
Human   105 LLVVTNVRSLQVPQLQQVGQLALLFSLTF---------ALLCCPFALGGPARGSAGAAGGPATAE 160

  Fly   170 ------LLATSV--------SLMYIGLFIYFLKSDDEDISEVVHDL--------------DTICV 206
                  ||.|.|        ||:.||..:....|         |.|              .|:..
Human   161 QGVWQLLLVTFVSYALLPVRSLLAIGFGLVVAAS---------HLLVTATLVPAKRPRLWRTLGA 216

  Fly   207 DIFHYLGFNLMGIFFRIMNDTMVRSSFLDRHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQ 271
            :...::|.|:.|:|.||:.:...|.:||.....:::.:.|....:::..||.|:||..:|..:::
Human   217 NALLFVGVNMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKE 281

  Fly   272 SI---KERIMLSETDSDRIVVNARRTENFMAIQIHPDVSILYADVVNYTHLTTTLTVEKLVKVLH 333
            ..   .|||.                 :.:.||.|.:||||:||:|.:|.|.:..|.::|||:|:
Human   282 DFLKPPERIF-----------------HKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLN 329

  Fly   334 DLYGRFDMAASTFKVQRIKFLGDCYYCVAGLGEADPDHARMAVSLGISMIANIQEVRAHRALDID 398
            :|:|:||..|:....:|||.||||||||:||.:...|||...|.:|:.||..|..|.....:|::
Human   330 ELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLN 394

  Fly   399 MRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGT 463
            ||:|:|:|.:|.||:|..|.|||:|..||.:||.:||.|.||.||::..||:.|| .:|.|.|| 
Human   395 MRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLN-GDYEVEPG- 457

  Fly   464 EVAQSDPILQKQPMTTYLLTAAPSRNSVRSVDAVHSYAEIDINALGASRKSPILRPTLMSD---E 525
                                ....|||......:.::..:      .|.:..|....::||   .
Human   458 --------------------YGHERNSFLKTHNIETFFIV------PSHRRKIFPGLILSDIKPA 496

  Fly   526 LREEFK----------------KMPVGGFNIRSPCCRDNSN-------DEKVNH----------- 556
            .|.:||                |..:...|:.:  |.|:..       .||:.:           
Human   497 KRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMT--CEDDDKRRALRTASEKLRNRSSFSTNVVYT 559

  Fly   557 ------------------------GLGMFCVAFKDSSLEWSYLHKPDFILKYSVLLA------WG 591
                                    .|..|.:.:|....|..|....|.....:|:|.      :|
Human   560 TPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQKYHQLQDEYFTSAVVLTLILAALFG 624

  Fly   592 IGCCLIYIQIVNDKFTICVECIVIDMVVFTFLTSLLFISWFKKVCWWRCVENDSRKYGRVSCKLF 656
            :...||:.|.|          :|:.::||.             :|:            .|:|.|:
Human   625 LVYLLIFPQSV----------VVLLLLVFC-------------ICF------------LVACVLY 654

  Fly   657 KIWERIQ-----HSFVLRVTIYMSIVASYYLLISTILLNCDKNQYELDVINSKLYHYDIVTDNCF 716
            ....|:|     .:..:|..:.:.||...|.:....::.|                         
Human   655 LHITRVQCFPGCLTIQIRTVLCIFIVVLIYSVAQGCVVGC------------------------- 694

  Fly   717 NPWVFTDM--ISLIV----GVSYTFARIPF-ALKMLITCCATVAYLVIVFFQYS----FIFEHSA 770
            .||.::..  .||:|    |.......:|. :....:.||......:.:||:.|    .|.....
Human   695 LPWAWSSKPNSSLVVLSSGGQRTALPTLPCESTHHALLCCLVGTLPLAIFFRVSSLPKMILLSGL 759

  Fly   771 TTTPFMKAELAHCLR--------------VCMML----LTMYAKERQSEFNTKINF----KINQD 813
            ||:..:..||:...|              |.::|    |.::|  ||.:...::::    :..::
Human   760 TTSYILVLELSGYTRTGGGAVSGRSYEPIVAILLFSCALALHA--RQVDIRLRLDYLWAAQAEEE 822

  Fly   814 LQGKQKAADITNKSIIILLTNILPSHVVEVYL-DSVANHELYYENYKMVSVMFAMLINF------ 871
            .:..:| ..:.|:.|   |.|:||:||.:.:| .:..|.:|||::|..|.||||.:.||      
Human   823 REDMEK-VKLDNRRI---LFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIE 883

  Fly   872 ----QMDLPSLRVLNDIITEFDRLLNAYKEYYV-VEKIKVVGCTYMAACGLDFTLAKSKFGSRTH 931
                .|.:..||:||:||.:||.|:.  |::|. :||||.:|.|||||.||..|     .|::..
Human   884 LDGNNMGVECLRLLNEIIADFDELME--KDFYKDIEKIKTIGSTYMAAVGLAPT-----SGTKAK 941

  Fly   932 ASYSSELEQVLYRKESKGTENDHDEVAFIMTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIG 996
            .|.||.|.                    .:..||:::..||...|.        ::.:...:.:|
Human   942 KSISSHLS--------------------TLADFAIEMFDVLDEINY--------QSYNDFVLRVG 978

  Fly   997 ISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTQETANILEQFDIMCMYRGMTFV 1061
            |:.|.::|||:||.:|.||||||.||:||||:|||:.|.|.||:|...:|.:.....:.||...|
Human   979 INVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVCRGKVSV 1043

  Fly  1062 KGRGEIPTYFV 1072
            ||:||:.|||:
Human  1044 KGKGEMLTYFL 1054

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXBNP_620474.2 AC_N <36..276 CDD:292831 39/201 (19%)
CYCc 249..459 CDD:214485 84/212 (40%)
Nucleotidyl_cyc_III 298..484 CDD:299850 78/185 (42%)
CYCc 825..1047 CDD:214485 85/233 (36%)
Nucleotidyl_cyc_III 853..1072 CDD:299850 85/229 (37%)
ADCY1NP_066939.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..28
AC_N <161..292 CDD:292831 31/156 (20%)
CYCc 258..453 CDD:214485 83/212 (39%)
Guanylate_cyc 294..476 CDD:278633 81/203 (40%)
Interaction with calmodulin. /evidence=ECO:0000250 493..520 3/26 (12%)
CYCc 826..1037 CDD:214485 87/249 (35%)
Guanylate_cyc 859..1056 CDD:278633 86/231 (37%)
Interaction with calmodulin. /evidence=ECO:0000250 1024..1047 6/22 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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