DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXB and Adcy3

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	NP_612178.2	Gene:	Adcy3 / 104111	MGIID:	99675	Length:	1145	Species:	Mus musculus

Alignment Length:	1233	Identity:	337/1233 - (27%)
Similarity:	536/1233 - (43%)	Gaps:	291/1233 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PRKCYLDYTDERLWERGYLKAKCKELCLEEEYKKYQIRLMISYLTVFFPLF-IFVVVGCELCPWI 72
            ||...|.:..|.|..            |.:.|.|.|....:..|.||..|| .:|||   :|..:
Mouse    50 PRFMRLTFVPESLEN------------LYQTYFKRQRHETLLVLVVFAALFDCYVVV---MCAVV 99

  Fly    73 FSEQK---------KLIYYESLTAIVVLVAVPGILSINFFESFVLRHRWIMVFSSILSAYIVVLV 128
            ||..|         .|:    |..|:.::...|:|........|....|:::.:
Mouse   100 FSSDKLAPLMVAGFGLV----LDIILFVLCKKGLLPDRVSRKVVPYLLWLLISA----------- 149

  Fly   129 DIFQILVFHF-KYHWPLNTL-YDVFVLCMIYMFLP--IPSIRGAALLATSVSLMYIGLFIYFLKS 189
            .||..|..:| :.|...:|: :..|.:...::.||  :..|...::::..|..:.:|:.:   ..
Mouse   150 QIFSYLGLNFSRAHAASDTVGWQAFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTV---AQ 211

  Fly   190 DDEDISEVVHDLDTICVDIFHYLGFNLMGIFFRIMNDTMVRSSFLDRHQFLKEEMWLRQARQQES 254
            ..:|..|.:..|..|..::|.||...::||....|.|...|.:||:..|.|:.:|.|.:..||:.
Mouse   212 QQQDELEGMQLLREILANVFLYLCAIIVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQE 276

  Fly   255 MLLDSILPPQIAKPIQQSIKERIMLSETDSDRIVVNARRTENFMAIQIHPDVSILYADVVNYTHL 319
            .|:.||||..:|..:.:.:|:    .|:..|      ::..|.|.:..|.:||||:||:|.:|.|
Mouse   277 NLMLSILPKHVADEMLKDMKK----DESQKD------QQQFNTMYMYRHENVSILFADIVGFTQL 331

  Fly   320 TTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVAGLGEADPDHARMAVSLGISMIA 384
            ::..:.::|||:|::|:.|||..|:.:...|||.|||||||:.||.:...|||..::.:|::|:.
Mouse   332 SSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVE 396

  Fly   385 NIQEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTL 449
            .|..||......:|||:|||:||:|.||:||.:.|||:|..||.:||::||.|.||.||:|..|:
Mouse   397 AISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTM 461

  Fly   450 SSLNVAEYTVFPGTEVAQSDPILQKQPMTTYLLTAAPSRNSVRSVDAVHSYAEIDINAL----GA 510
            ..|. .|:.|.||...::.| .|.::.:.|||:.|        |...|...|:..:|..    ||
Mouse   462 DCLK-GEFDVEPGDGGSRCD-YLDEKGIETYLIIA--------SKPEVKKTAQNGLNGSAVPNGA 516

  Fly   511 SRKSPILRPTLM-----------SDELREEFKKMPVGGFNIRSPCCR-------------DNSND 551
            ...|....|.|:           |....||.::......|...|..|             |.|.|
Mouse   517 PASSKPSSPALIETKEPNGSAHASGSTSEEAEEQEAQADNPSFPNPRRRLRLQDLADRVVDASED 581

  Fly   552 EKVNHGLGMF------------CVAFKDSSLEWSYLHKPDFILKYSVL------LAWGIGC---- 594
            |   |.|...            .|..:::.|.......|:...:|||.      .|:...|
Mouse   582 E---HELNQLLNEALLERESAQVVKKRNTFLLTMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLF 643

  Fly   595 CLIYIQIVNDKFTIC-VECIVIDMVVFTFLT---------------SLLFISWFKKVCWWRCVEN 643
            |...::|:.|.:.:. ....|:..|:...||               .:.|.||..:..|.|
Mouse   644 CTAMVEILIDPWLMTNYVTFVVGEVLLLILTICSMAAIFPRSFPKKLVAFSSWIDRTRWAR---- 704

  Fly   644 DSRKYGRVSCKLFKIWERIQHSFVLRVTIYMSIVASYYLLISTI--LLNCDKNQY---------- 696
                         ..|               :::|.:.|:::.:  :|:|  .||
Mouse   705 -------------NTW---------------AMLAIFILVMANVVDMLSC--LQYYMGPYNMTAG 739

  Fly   697 -ELD---VINSKLYHYDIVTDNCFNPWVFTDMISLI-----VGVSYTFARIPFALKMLITCCATV 752
             |||   :.|.|.|:|..|             :|||     |.||:   .:...|.:|:|...|.
Mouse   740 MELDGGCMENPKYYNYVAV-------------LSLIATIMLVQVSH---MVKLTLMLLVTGAVTA 788

  Fly   753 AYLVI---VFFQYSFIFEH--------------------------SATTTPFMKAELAHCLRVCM 788
            ..|..   ||.:|    :|                          :.:..|.:.::.:..:.:.:
Mouse   789 LNLYAWCPVFDEY----DHKRFQEKDSPMVALEKMQVLATPGLNGTDSRLPLVPSKYSMTVMMFV 849

  Fly   789 MLLTMYAKERQSE--FNTKINFKINQDLQGKQKAADIT--NKSIIILLTNILPSHVVEVYLDS-V 848
            |:|:.|...|..|  ..|...:||....| |::..::.  |::   |:||:||.||...:|.| .
Mouse   850 MMLSFYYFSRHVEKLARTLFLWKIEVHDQ-KERVYEMRRWNEA---LVTNMLPEHVARHFLGSKK 910

  Fly   849 ANHELYYENYKMVSVMFAMLINF----------QMDLPSLRVLNDIITEFDRLLNAYKEYYVVEK 903
            .:.|||.::|..:.||||.|.||          ...:..||.||:||::||.||:..| :.|:.|
Mouse   911 RDEELYSQSYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPK-FRVITK 974

  Fly   904 IKVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAFIMTTFALDL 968
            ||.:|.|||||.|:...:..:.|.|.:              ||.|..:.....:| .:..|||.:
Mouse   975 IKTIGSTYMAASGVTPDVNTNGFTSSS--------------KEEKSDKERWQHLA-DLADFALAM 1024

  Fly   969 MRVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLP 1033
            ...|:..|        :::.:...:.||::.|.::|||:||.:||||||||.||:||||||||:.
Mouse  1025 KDTLTNIN--------NQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVM 1081

  Fly  1034 GHIHVTQETANILEQFDIMCMYRGMTFVKGRGEIPTYFV-GIDDNLKF-------LPSNVKKN 1088
            |:|.|.:||..||.::....:.||..||||:||:.|:|: |.|....|       ||..|..|
Mouse  1082 GNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDRPAAFPNGSSVTLPHQVVDN 1144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	62/253 (25%)
		CYCc	249..459	CDD:214485	84/209 (40%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	80/185 (43%)
		CYCc	825..1047	CDD:214485	86/232 (37%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	85/228 (37%)
Adcy3	NP_612178.2	AC_N	<44..303	CDD:318454	68/289 (24%)
		Guanylate_cyc	310..494	CDD:306677	80/185 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..564		11/59 (19%)
		Guanylate_cyc	915..1122	CDD:306677	86/230 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810