Protein Alignment ACXB and Adcy4

DIOPT Version :10

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: NP_536683.1
• Gene: Adcy4 / 104110
• MGIID: 99674
• Length: 1077
• Species: Mus musculus
• Alignment Length: 1135
• Identity: 294/1135 - (25%)
• Similarity: 509/1135 - (44%)
• Gaps: 209/1135 - (18%)

  Fly    56 FPLFI--FVVVGCEL--CPWIFSEQKKLIYYESLTAIVVLVAVPG---ILSINFFESFVLRHRWI 113
            :||.|  .|:|.|.|  .|.:.....:.:..:......||.|:.|   :|.:...|..:  .||.
Mouse    27 YPLLILLLVIVLCALVALPAVAWASGRELTSDPSFLTTVLCALGGFSLLLGLASREQQL--QRWT 89

  Fly   114 MVFSSILSAYIVVLVDIFQILVFHFKYHWPLNTLYD-----VFVLCMIYMFLPIPSIRGAA---L 170
            ...|.::  ::.:|.     |.:.|.:...:.:.:|     :|::..:|..||: .:|.||   :
Mouse    90 RPLSGLI--WVALLA-----LGYGFLFTGGVVSAWDQVSFFLFIIFTVYAMLPL-GMRDAAAAGV 146

  Fly   171 LATSVSLMYIGLFIYFLKSDDEDISEVVHDLDTICVDIFHYLGFNLMGIFFRIMNDTMVRSSFLD 235
            :::...|:.:||::.:.......:      |..:..:...:|..|::|.:.:.:.:..:|::|.:
Mouse   147 ISSLSHLLVLGLYLGWQPESQRAL------LPQLAANAVLFLCGNVVGAYHKALMERALRATFRE 205

  Fly   236 RHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSIKERIMLSETDSDRIVVNARRTENFMAI 300
            ....|.....|...::.:..||.||||..:|:.::..|..|:...:..      ....|.||.::
Mouse   206 ALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQRS------RPENTNNFHSL 264

  Fly   301 QI--HPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVAG 363
            .:  |..||:||||:|.:|.|.:..:.::||.:|::|:|:||..|...:..|||.||||||||:|
Mouse   265 YVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSG 329

  Fly   364 LGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPDVD 428
            |..:.||||...|.:|:.|...|:::|....:||:||:|||||::|.||||..|.|||:|..||.
Mouse   330 LPLSLPDHAINCVRMGLDMCRAIRKLRVATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVT 394

  Fly   429 IANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPMTTYLLTAAPSRNSVRS 493
            :||.:||.|.||.||::|.||:.| ...|.| ...:....||.|::....|||:....:......
Mouse   395 LANHMEAGGVPGRVHITGATLALL-AGAYAV-ERADTEHRDPYLRELGEPTYLVIDPRAEEEDEK 457

  Fly   494 VDAVHSYAEIDINALGASRKSPILRPTLMSDELREEF-------------------KKMPVGGFN 539
            ..|         ..|.:|.:...:||:|:.....|.:                   ..:|...|:
Mouse   458 GTA---------KGLLSSLEGHTMRPSLLMTRYLESWGAAKPFAHLSHLDSPVSTSTPLPEKAFS 513

  Fly   540 -------IRSPCCRDNSND----------EKVN--------HGLGMFCVAFKDSSLEWSYLHKPD 579
                   .|:|...|:..|          |::|        ....:..:.|::..:|..|
Mouse   514 PQWSLDRSRTPRGLDDELDTGDAKFFQVIEQLNSQKQWKQSKDFNLLTLYFREKEMEKQY----- 573

  Fly   580 FILKYSVLLAWG-IGCCLIYIQIVNDKFTICV-------ECIVIDMVVFTFLTSLLFISWFKKVC 636
               :.|.|.|:. ...|...:.:.|  |||.:       ..|:...:.|.....|||:.:.:.:.
Mouse   574 ---RLSALPAFKYYAACTFLVFLSN--FTIQMLVTTRPPALIITYSITFLLFFLLLFVCFSEHLT 633

  Fly   637 WWRCVENDSRKYGRVSCKLFKIWERIQHSFVLRVTIYMSIVASYYLLISTILLNCDKNQYELDVI 701
              :||:...:....:......:..|......|...   :|:..:.:.|:::|.        |.|.
Mouse   634 --KCVQKGPKMLHWLPALSVLVATRPGFRVALGTA---TILLVFTMAIASLLF--------LPVS 685

  Fly   702 NSKLYHYDIVTDNCFN-PWVFTDMISLI----VGVSYT-------------FARIPFALKMLITC 748
            :..|:....|:...|| .|.....:.||    :.:.|:             |..:.|.||:|:..
Mouse   686 SDCLFLASNVSSVTFNASWEMPGSLPLISIPLISIPYSMHCCVLGFLSCSLFLHMSFELKLLLLL 750

  Fly   749 CATVAYLVIVFFQYSF--------IFEHSATTTP--FMKAELAHCLRVCMMLLTMYAKERQSEFN 803
            ...||...:....:::        :::..:.:.|  ..:.:|...:...:...|:....||:|:.
Mouse   751 LWLVASCSLFLHSHAWLSDCLIARLYQSPSDSRPGVLKEPKLMGAIYFFIFFFTLLVLARQNEYY 815

  Fly   804 TKINF----KINQDLQGKQKAADITNKSIIILLTNILPSHVVEVYL-DSVANHELYYENYKMVSV 863
            .:::|    |:.|:.:..:...::|.    :||.|:||:||...:: .:..|.:||:::|:.|.|
Mouse   816 CRLDFLWKKKLRQEREETETMENLTR----LLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCV 876

  Fly   864 MFAMLINFQ----------MDLPSLRVLNDIITEFDRLLNAYKEYYVVEKIKVVGCTYMAACGLD 918
            :||.:.:|:          ..|..||:||:||.:||.||:..| :..|||||.:|.|||||.||:
Mouse   877 LFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPK-FSGVEKIKTIGSTYMAATGLN 940

  Fly   919 FTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAF---IMTTFALDLMRVLSVCNKAYA 980
            .|                         ..:.|:.|.:....   .|..||:.|...|.|.||
Mouse   941 AT-------------------------SGQDTQQDSERSCSHLGTMVEFAVALGSKLGVINK--- 977

  Fly   981 GRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTQETANI 1045
                 .:.:...:.:|::.|.::|||:||.:|.||||||.||:||||||||:.|.|.||:|||..
Mouse   978 -----HSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETARA 1037

  Fly  1046 LEQFDIMCMYRGMTFVKGRGEIPTYFVGID 1075
            |:.....|..||...|||:||:.|||:..|
Mouse  1038 LQSLGYTCYSRGSIKVKGKGELCTYFLNTD 1067

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AcyC	85..452	CDD:441717	116/379 (31%)
		Nucleotidyl_cyc_III	298..484	CDD:448371	82/187 (44%)
		Nucleotidyl_cyc_III	853..1072	CDD:448371	86/231 (37%)
Adcy4	NP_536683.1	AcyC	40..453	CDD:441717	127/436 (29%)
		Guanylate_cyc	264..447	CDD:425528	82/184 (45%)
		Adcy_cons_dom	479..581	CDD:461877	14/109 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	503..524		3/20 (15%)
		Guanylate_cyc	866..1065	CDD:425528	87/232 (38%)