Protein Alignment ACXB and adcy4

DIOPT Version :9

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: XP_002934331.3
• Gene: adcy4 / 100497212
• XenbaseID: XB-GENE-984909
• Length: 1072
• Species: Xenopus tropicalis
• Alignment Length: 1160
• Identity: 324/1160 - (27%)
• Similarity: 518/1160 - (44%)
• Gaps: 218/1160 - (18%)

  Fly    25 GYLKAKC-KELCLEEEYKKYQIRLMISYLTVFFPLFIFVVVGCELCPWIFSEQKKLIYYESLTAI 88
            |:.:.:| ||..|.|.|    .||...|..:...|.|.:.|.|.|....|:..:  .:.:::..:
 Frog    10 GHYRQRCEKEGPLYETY----YRLTQQYPVILLLLLIVLAVCCALIIITFATGR--TFSDNVGFL 68

  Fly    89 VVLVAVPGILSINFFESFVLRHRWIMVFSSILSAYIVVLVDIFQILVFHFKYHWPLNTLYD---- 149
            |.|....|:.||.|....:.:     |....:....||::.....|.:.|.:...|.:.:|
 Frog    69 VTLFCALGVFSILFIPVCIKK-----VVQKCMQIIGVVILGCLVTLGYVFIFTSGLVSAWDQIYW 128

  Fly   150 -VFVLCMIYMFLPIPSIRGAALLATSVSLMY-IGLFIY-----FLKSDDEDISEVVHDLDTICVD 207
             :||:..:|..||: .::.|.....|..:.: |.|.:|     .|..||..:..:...:..:|
 Frog   129 TLFVIISLYTMLPL-GMKWAIFAGLSCFVAHIIVLSVYVSTVRLLPRDDVALQMIADAVILLC-- 190

  Fly   208 IFHYLGFNLMGIFFRIMNDTMVRSSFLDRHQFLKEEMWL-RQARQQESMLLDSILPPQIAKPIQQ 271
                  .|::|.:.:.:.::.::.::.:...|:...:.| .|.||||.:|| ||||..||..::.
 Frog   191 ------GNVIGGYHKCVTESALKDTYHEAINFIHSRLKLVSQERQQERLLL-SILPAYIATEMKA 248

  Fly   272 SIKERIMLSETDSDRIVVNARRTENF--MAIQIHPDVSILYADVVNYTHLTTTLTVEKLVKVLHD 334
            .|.||:.......:       .|.||  :.|:.|.||||||||:|.:|.|::..:.::||.:|::
 Frog   249 EIIERLKEKRPQPE-------NTNNFHNLYIKRHKDVSILYADIVGFTLLSSECSPKELVLMLNE 306

  Fly   335 LYGRFDMAASTFKVQRIKFLGDCYYCVAGLGEADPDHARMAVSLGISMIANIQEVRAHRALDIDM 399
            |:|:||..|...:..|||.||||||||:||.|..|:||:..|.:|:.|...|:::|....:||:|
 Frog   307 LFGKFDQIAKDNECMRIKILGDCYYCVSGLPEFLPNHAKNCVLMGLDMCQAIRKLRKATGVDINM 371

  Fly   400 RIGVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTE 464
            |:|||||.:|.||||..|.|||:|..||.:||.:||.|.||.||::..|||.|. .||.|...|
 Frog   372 RVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITEATLSHLE-NEYEVEDAT- 434

  Fly   465 VAQSDPILQKQPMTTYLL-----------TAAPS--------RNSVRSVDAVHSYAEIDINALGA 510
            :||.|..|::..:.|||:           ...||        |.|||....:.|:......|..:
 Frog   435 LAQRDLYLKENNIKTYLVIDPRANDGEAEDILPSKSAEVPKMRASVRMTRYLESWGAEKPFAHLS 499

  Fly   511 SRKSPILRPTLMSDEL-------------------REEFKKMPVGGFNIRSPCCRDNSNDEKVNH 556
            .|.|.:..|..:|..:                   ||..:.:....|:|.....  :....|.:.
 Frog   500 HRDSLVPEPHSISHSMDLPMSPLSQTWSQEKSRSTRETNESLNDNNFHIMEVLA--SQRQWKRSK 562

  Fly   557 GLGMFCVAFKDSSLEWSY--LHKPDFILKYSVLLAWGIGCCLIYIQIV----NDKFTICVECIVI 615
            ......:.|.|.:.|..|  ...|.|  ||.....:.|..|...:||:    |..|.|...
 Frog   563 DFNRITLYFNDKAAEKEYRLSDLPSF--KYYTACCFFIFACNFIVQILVSHKNAAFGISYG---- 621

  Fly   616 DMVVFTFLTSLLFISWFKKVCWWRCVEN---------------DSRKYGRVSCKLFKIWERIQHS 665
              :.|.|...|||..:...:.  ||:..               .||.:.||...:|.|
 Frog   622 --ISFFFFLLLLFTCFAGHLA--RCILKGPQLLHWLPSLSIALSSRPWLRVPLGVFTI------- 675

  Fly   666 FVLRVTIYMSIVASYYLLISTILLNCDKNQY--------ELDVINSKLYHYDIVTDNCFNPWVFT 722
                :|:.:..|.:.:.|...   ||.:..:        |..::.|..|:
 Frog   676 ----LTVLVMAVFNLFFLPDN---NCPQQSWNSSLSPDPEPQMLYSLPYY--------------- 718

  Fly   723 DMISLIVGV--SYTFARIPFALKMLITCCATVAYLVIVFFQYSFI---------FEHSATTTPFM 776
             |...|:|:  ...|..:.|..|:::...|.|.|.||....:|::         ..||.... ..
 Frog   719 -MYCCILGLLACSAFLLMNFEAKLILLSIALVIYNVIFLETHSWLSDCYVNWLYMNHSRPGI-LK 781

  Fly   777 KAELAHCLRVCMMLLTMYAKERQSEFNTKINFKINQDLQGKQKAADITNKSIIILLTNILPSHVV 841
            :.::...:.:.:...|:.|..||:|:..:::|...:..:.:::..:.......:||.|:||:.|.
 Frog   782 EPKVMGSISLFIFFFTLLALSRQNEYYCRLDFLWKRKFKMERERIETMENLNRVLLENVLPADVA 846

  Fly   842 EVYL-DSVANHELYYENYKMVSVMFAMLINFQ----------MDLPSLRVLNDIITEFDRLLNAY 895
            :.:: .:..|.:|||::|..|.|:||.:.:|:          ..|..||:||:||.:||.||:..
 Frog   847 QQFIGQNRRNEDLYYQSYDCVCVLFASIPDFKEFYTECDENHEGLECLRLLNEIIADFDELLSKP 911

  Fly   896 KEYYVVEKIKVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHD----- 955
            | :..|||||.:|..||||.||:.|                           .|.||..|
 Frog   912 K-FSSVEKIKTIGSAYMAATGLNAT---------------------------SGQENPQDGDRNY 948

  Fly   956 EVAFIMTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNP 1020
            ....||..||:.|:..|.:.||        .:.:..::.:||:.|.::|||:||.:|.||||||.
 Frog   949 NHIGIMVEFAIALIGKLDLINK--------HSFNNFKLRVGINHGPVVAGVIGAQKPQYDIWGNT 1005

  Fly  1021 VNMASRMESTGLPGHIHVTQETANILEQFDIMCMYRGMTFVKGRGEIPTYFVGID 1075
            ||:||||:|||:.|.|.||:||..:||:....|..||:..|||:|::.||||..|
 Frog  1006 VNVASRMDSTGVLGKIQVTEETTKVLEKLGYKCERRGVIKVKGKGQLCTYFVSTD 1060

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	57/251 (23%)
		CYCc	249..459	CDD:214485	97/211 (46%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	88/196 (45%)
		CYCc	825..1047	CDD:214485	83/237 (35%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	87/233 (37%)
adcy4	XP_002934331.3	AC_N	<17..250	CDD:318454	58/253 (23%)
		Guanylate_cyc	270..427	CDD:306677	77/157 (49%)
		DUF1053	483..586	CDD:399378	15/104 (14%)
		Guanylate_cyc	859..1057	CDD:306677	87/233 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48748
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020