Protein Alignment ACXB and gucy2d

DIOPT Version :10

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: XP_002942678.2
• Gene: gucy2d / 100496590
• XenbaseID: XB-GENE-1014102
• Length: 1081
• Species: Xenopus tropicalis
• Alignment Length: 1000
• Identity: 197/1000 - (19%)
• Similarity: 303/1000 - (30%)
• Gaps: 438/1000 - (43%)

  Fly   349 QRIKFLGDCYYCVAGLGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVI 413
            ||:|.:..|.:.|...||   |..|:           ::|  ||     |||:...|...:....
 Frog   217 QRVKVVVMCMHSVLIGGE---DQRRL-----------LEE--AH-----DMRMADGSVVFIPYDT 260

  Fly   414 GQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGT----EVAQSDPILQK 474
            .|..|.||...|......:|    :..|..|...|.||.:...|..|...    ||.|.....:.
 Frog   261 LQFSLPYDRIFPVFTNNTKL----RRAYDAVLTITASSEHGNFYETFQDAKARHEVPQDIDPTEV 321

  Fly   475 QPM------TTYLLTAAPSRNSVRSVDAVHSY-AEIDINALGASRKSPILRPTLMSDELREEFKK 532
            .|:      :.|||.|...|          || |...:.|...:|.:                |.
 Frog   322 SPLFATIYNSIYLLGATADR----------SYQATQRVTASSTTRHA----------------KN 360

  Fly   533 MPVGGFNIRSPCCRDNSNDEKVNHGLGMFCVAFKD------------SSLEWSYLHKPDFILKYS 585
            :.:.||..  |...|...|.:.|     |.:...|            .|.....:.:.|....||
 Frog   361 IQLEGFGY--PVNLDEDGDSQTN-----FVILDTDGESRRLFPVYTFQSATGDLIFRRDIHFPYS 418

  Fly   586 VLLAWGIGCCLIYIQIVNDKFTICVECI--VIDMVVFTFLTSLLFI----SWF------------ 632
            ..:.....|..       |:.|||...:  ....::|..|:|.:.|    :|:
 Frog   419 YRIGTDSDCWF-------DRNTICTGGVDPAYVFLIFILLSSFILIGGSFTWYIRRRIHYAKLAK 476

  Fly   633 --------------------KKVCWWRCVENDSR------------------------------- 646
                                |||.      :|||
 Frog   477 GPNKIFLTMEDLTFIHSHSKKKVV------DDSRSSLLGRSVSDMRTPRHSVSGKSVAAATPHNT 535

  Fly   647 ------------------KYG-------RVSCKLFKIWERIQHSFVLRVTIYMSIVASYYLLIST 686
                              |:|       .|.|||    ..::|.   .:.:|:.:..... :|..
 Frog   536 NIGVFEGDWVWLKKFPGEKHGDLRPATKNVFCKL----RELRHE---NINLYLGLFDDIG-VIGV 592

  Fly   687 ILLNCDKNQYELDVINSKLYHYDIVTDNCFNPWVFTD--MISLIVGVSYTFAR-IP--------- 739
            :..:|.:...| |:|.::    |:..|     |:|..  ::.||.|:.:...| :|
 Frog   593 VSEHCSRGSLE-DLIQNQ----DMKLD-----WMFKSSLLLDLIKGLKFLHHRELPHGRLKSRNC 647

  Fly   740 -----FALKML---------------------------------ITCCATVAYLVIVFFQYSFIF 766
                 |.||:.                                 .|.|....|...:   |||..
 Frog   648 VVDGRFVLKLTDFGMNELYDAQRLPSTQLQPEDLFWTAPELLRDATLCQRGTYRGDI---YSFAI 709

  Fly   767 ---EHSATTTPFMKAELA--------------------------HC---LRVC------------ 787
               |......|:...|:.                          .|   :::|
 Frog   710 IMQEVIVRGPPYCMLEVTADEIIRKVLRPPPLCRPSVSLDQAPPECIQLMKLCWSEQPERRPTID 774

  Fly   788 ---------------------MMLLTMYA-------KERQSEFNTKINFKINQDLQGKQKAADIT 824
                                 :.:|..|:       :||..|...:           |||    |
 Frog   775 QIFDQFKNINRGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELEVE-----------KQK----T 824

  Fly   825 NKSIIILLTNILPSHVVEVYLDSVANHELYYENYKMVSVMFAMLINFQMDLPSLR-------VLN 882
            :|    |||.:||..|.|...........|::.   |::.|:.::.| ..:.||.       :||
 Frog   825 DK----LLTQMLPPSVAEALKTGTPVEPEYFDE---VTIYFSDIVGF-TTISSLSDPIEVVDLLN 881

  Fly   883 DIITEFDRLLNAYKEYYVVEKIKVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKES 947
            |:.|.||.::.::..|    |::.:|..||.|.||      .|.....||:
 Frog   882 DLYTLFDAIIGSHDVY----KVETIGDAYMVASGL------PKTNGNRHAA-------------- 922

  Fly   948 KGTENDHDEVAFIMTTFALDLMRVLSVCNKAYAGRPFDRALSTG------------EICIGISTG 1000
                    |:|    ..:||::.                  |.|            .|.||:.:|
 Frog   923 --------EIA----NMSLDILS------------------SVGSFKMRHMPDVPVRIRIGLHSG 957

  Fly  1001 EIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTQETANILE------QFDIMCMYRGMT 1059
            ..:|||||.:.|.|.::|:.||.||||||||||..:||...|..||.      :|::    ||.|
 Frog   958 PCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRVHVNLSTVTILHSLKEGYRFEV----RGKT 1018

  Fly  1060 FVKGRGEIPTYF-VGIDDNLKFLPS 1083
            .:||:|...||: ||.:...|.||:
 Frog  1019 ELKGKGVEDTYWLVGKEGFTKPLPT 1043

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AcyC	85..452	CDD:441717	26/102 (25%)
		Nucleotidyl_cyc_III	298..484	CDD:448371	36/144 (25%)
		Nucleotidyl_cyc_III	853..1072	CDD:448371	67/244 (27%)
gucy2d	XP_002942678.2	PBP1_sensory_GC_DEF-like	43..411	CDD:380594	53/251 (21%)
		PK_GC-2D	519..786	CDD:270945	36/287 (13%)
		HNOBA	<795..840	CDD:462234	17/63 (27%)
		CYCc	820..1012	CDD:214485	70/268 (26%)