Protein Alignment ACXB and adcy6

DIOPT Version :10

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: XP_002935166.2
• Gene: adcy6 / 100493933
• XenbaseID: XB-GENE-1011902
• Length: 1239
• Species: Xenopus tropicalis
• Alignment Length: 1159
• Identity: 308/1159 - (26%)
• Similarity: 528/1159 - (45%)
• Gaps: 208/1159 - (17%)

  Fly     9 PRKCYLDYTDERLWERGYLKAKCKELCLEEEYKKYQIRLMISYLTVFFPLFIFVVVGCELCPWIF 73
            |.:|::.:.      :.:...|.:...||..|::|..::..|.||:.....:.|   | |...||
 Frog   187 PGECWVRFL------QVFQSKKFQSAKLERLYQRYFFQMNQSSLTMLMGALVLV---C-LVMLIF 241

  Fly    74 --SEQKKLIYYESLTAIVVLVAVPGILSIN---FFESFVLRHRWIMVFSSILSAYIVVLVDIFQI 133
              :..:..:.|.|:.|:.:.:.:..::..|   |.:.::    ||:       :|:|:.| :|.:
 Frog   242 HCTHGEPQVVYVSVLAVAMALFLSLMVVCNRNGFHQDYM----WIV-------SYLVIAV-LFAV 294

  Fly   134 LVFHFKYHWPLNT----LYDVFVLCMIYMFLPIPSIRGAALLATSVSLMYIGLFIYFLKSDDEDI 194
            .|.......|.:.    .:.||.:.:||..||: .:|.|.|....:|.::: :..:.|...|
 Frog   295 QVLGVLMVTPRSASEGIWWSVFFIYIIYTLLPV-RMRAAVLSGLILSSLHL-IISWRLNLTD--- 354

  Fly   195 SEVVHDLDTICVDIFHYLGFNLMGIFFRIMNDTMVRSSFLDRHQFLKEEMWLRQARQQESMLLDS 259
               :.....:..::..:|..|::||......:...|.:|.:...:::..:.|::..||:..||.|
 Frog   355 ---IFLWKQLSANVLIFLCTNIIGICTHYPAEVSQRQAFQETRGYIQARLHLQRENQQQERLLLS 416

  Fly   260 ILPPQIAKPIQQSI---KERIMLSETDSDRIVVNARRTENFMAIQIHPDVSILYADVVNYTHLTT 321
            :||..:|..:::.|   ||.:|..:                :.||.|.:||||:||:..:|.|.:
 Frog   417 VLPRHVAMEMKEDINTKKEDMMFHK----------------IYIQKHDNVSILFADIEGFTSLAS 465

  Fly   322 TLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVAGLGEADPDHARMAVSLGISMIANI 386
            ..|.::||..|::|:.|||..|:.....|||.||||||||:||.||..|||...|.:|:.||..|
 Frog   466 QCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAI 530

  Fly   387 QEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSS 451
            ..||....::::||:|:|||.:..||:|..|.|:|:|..||.:||.:||.||.|.:|::..||..
 Frog   531 SLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITSATLKY 595

  Fly   452 LNVAEYTVFPGTEVAQSDPILQKQPMTTYLLT-AAPSRNSVRSVDAVHSYAEIDINALGASRKSP 515
            || .:|.|.||.. .:.:..|::..:.|:|:| .:..|...:::.|....|..:.|. |.:|
 Frog   596 LN-GDYEVEPGNG-GERNAYLKEHDIKTFLVTGCSQKRKEEKAMMARLQRARANSNE-GLTR--- 654

  Fly   516 ILRP--TLMSDELREEFKKMPVGGFNIRSPCCRDNSN-------DEKVNHGLG------------ 559
            :..|  :...::..:.|::|.:      ....:||.|       :::|:..|.
 Frog   655 VWVPERSFPRNKGSKAFRQMGI------DESSKDNRNTQEALNPEDEVDEFLARAIDARSIDQLR 713

  Fly   560 -----MFCVAFKDSSLEWSYLHKPDFILKYSVLLAWGIGCCLIYIQIVNDKFTICVECIVIDMVV 619
                 .|.:.|:...||..|..|.|......|.....:.|.:.:||||  .|......:.:...|
 Frog   714 KDHVKKFLLTFQTPDLEKKYSKKVDDRFGGYVTCTLLVFCFICFIQIV--IFPHSFLMLGVYTSV 776

  Fly   620 FTFLTSLLFISWFKKVC-WWRCVENDSRKYGRVSCKLFKIWERIQHSFVLRVTIYMSIVASYYLL 683
            |..|.|:||      || .:.|::........||.|:  :..|...:.:..:||.:...:::..:
 Frog   777 FIILASILF------VCAIYSCIKLFPAALQGVSRKI--VQSRTNSTLIGILTILLVFTSAFVNM 833

  Fly   684 IS---TILLNCDKNQYEL-----DVINSKLYHYDIVTDN---------CFNPWVFTDMISLIVGV 731
            .:   ..|.:|...:..:     :|.:.::.:|.:..|:         |..|..|...|.|.:..
 Frog   834 FACNHRSLTDCAGQELNISYKFVNVCHLRMLNYSLSMDSPPCDSDKPLCNFPEYFNYSILLSLLA 898

  Fly   732 SYTFARIPFALKMLITCCATVAYLVIV-------FFQYSFIFEHSA----------TTTPFMKAE 779
            ...|.:|....|:.:.....:.|:|||       |..|..:...:|          ...|..|..
 Frog   899 CSVFLQISSIGKLALMLFIQILYIVIVEGPEVVLFDNYDLLVTVNALPINGTGDIEECLPSSKIA 963

  Fly   780 LAHCLRVCM--MLLTMYAKERQSEFNTKINFKINQDLQGKQKAADITNKSIIILLTNILPSHVVE 842
            |.....|.:  .:|.:|...:|.|...:::|.......|:::..:........||.||||..|..
 Frog   964 LKFVTPVILTVFVLALYLHAQQVESTARLDFLWKLQATGEKEEMEQLQAYNRRLLHNILPKDVAA 1028

  Fly   843 VYL-DSVANHELYYENYKMVSVMFAMLINFQ---MDLPS-------LRVLNDIITEFDRLLNAYK 896
            .:| ....|.||||::.:.|:||||.:.||.   ::|.:       ||:||:||.:||.:::..|
 Frog  1029 HFLAREHRNDELYYQSCECVAVMFASICNFSEFYVELEANNEGVECLRLLNEIIADFDEIISEEK 1093

  Fly   897 EYYVVEKIKVVGCTYMAACGL-DFTLAKSKFGSRTH----ASYSSEL-EQVLYRKESKGTENDHD 955
             :..:||||.:|.|||||.|| |.|..|.   .:||    |.|:.:| ||:.|       .|:|
 Frog  1094 -FKQLEKIKTIGSTYMAASGLNDTTYDKE---GKTHITALADYAMKLREQMKY-------INEH- 1146

  Fly   956 EVAFIMTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNP 1020
                                           :.:..::.||::.|.::|||:||.:|.||||||.
 Frog  1147 -------------------------------SFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNT 1180

  Fly  1021 VNMASRMESTGLPGHIHVTQETANIL--EQFDIMCMYRGMTFVKGRGEIPTYFV 1072
            ||:||||:|||||..|.||.:...:|  :.:.:.|  ||:..|||:||:.|||:
 Frog  1181 VNVASRMDSTGLPDCIQVTTDLYQVLAAKGYQMEC--RGVIKVKGKGEMTTYFL 1232

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AcyC	85..452	CDD:441717	112/376 (30%)
		Nucleotidyl_cyc_III	298..484	CDD:448371	80/186 (43%)
		Nucleotidyl_cyc_III	853..1072	CDD:448371	85/236 (36%)
adcy6	XP_002935166.2	AC_N	89..440	CDD:318454	59/282 (21%)
		Guanylate_cyc	442..626	CDD:425528	79/185 (43%)
		Adcy_cons_dom	656..741	CDD:461877	15/90 (17%)
		Guanylate_cyc	1040..1233	CDD:425528	86/238 (36%)