Protein Alignment ACXB and adcy1

DIOPT Version :9

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: XP_002933461.1
• Gene: adcy1 / 100492373
• XenbaseID: XB-GENE-950909
• Length: 1122
• Species: Xenopus tropicalis
• Alignment Length: 1205
• Identity: 312/1205 - (25%)
• Similarity: 512/1205 - (42%)
• Gaps: 322/1205 - (26%)

  Fly    31 CKELCLEEEYKKYQIRLMISYLTVFFPLFIFVVVGCELCPWIFSEQKKLIYYESLTAIVVLVAVP 95
            |||  ||..::.|.::|                           ||.     .:|.|:.||:.:.
 Frog    40 CKE--LESLFQNYNLKL---------------------------EQT-----STLKALAVLIIMT 70

  Fly    96 GIL---------SINFFESFVLRHRWIMVFSSILSAYIVVLVDIFQI----------LVFHFKYH 141
            |.|         |:...:.....|  .::|   ||.:||..|...|:          |:|.|.:.
 Frog    71 GTLALLELMSGPSLTISKGSHPVH--CIIF---LSLFIVTNVKYLQVTQLQQIVKLTLLFGFTFS 130

  Fly   142 W--------------PLNTLYDVFVLCMI----YMFLPI-----------PSIRGAALLATSVSL 177
            :              |:::...::.|.::    |..||:           .|:....:.|||:|.
 Frog   131 FLCCPFSLGAYGLEPPVSSEQGLWQLMLVTFVAYALLPVRTLLAIVFGFMVSVSHIIVTATSISP 195

  Fly   178 MYIGLFIYFLKSDDEDISEVVHDLDTICVDIFHYLGFNLMGIFFRIMNDTMVRSSFLDRHQFLKE 242
            ....|:                  .|:.|:...::..||.|:|.||:.:...|.:||.....:::
 Frog   196 KKKRLW------------------RTLVVNAILFVSVNLSGVFVRILTERAQRKAFLQARNCIED 242

  Fly   243 EMWLRQARQQESMLLDSILPPQIAKPIQQSI---KERIMLSETDSDRIVVNARRTENFMAIQIHP 304
            .:.|....:::..||.|:||..:|..:::..   .|||.                 :.:.||.|.
 Frog   243 RLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIF-----------------HKIYIQRHD 290

  Fly   305 DVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVAGLGEADP 369
            :||||:||:|.:|.|.:..|.::|||:|::|:|:||..|:....:|||.||||||||:||.:...
 Frog   291 NVSILFADIVGFTSLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKT 355

  Fly   370 DHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLE 434
            |||...|.:|:.||..|..|.....:|::||:|:|:|.:|.||:|..|.|||:|..||.:||.:|
 Frog   356 DHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVME 420

  Fly   435 ATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPMTTYLLTAAPSRN---------- 489
            |.|.||.||::..||..|| .:|.|.||.. .:.:..|:|..:.|:.:..:..|.
 Frog   421 AGGLPGKVHITKNTLECLN-GDYEVEPGYG-HERNSFLKKHNIETFFIVPSHRRKIFPGLILSDI 483

  Fly   490 --SVRSVDAVHSYAEIDINALGASRKSPILRPTLMSDELREEFKKMPVGGFNIR-----SPCCRD 547
              :.|.......|..:.:.......|:.|....:|:.|..::.:.:......:|     |.....
 Frog   484 KPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRNRSSFSTNVIH 548

  Fly   548 NSNDEKVNHGLGMFCVAFKDSSLEWSYLHKPDFI-LKY-----------------------SVLL 588
            |:...:||..:|....| :.:..|.|.|   :|| |||                       |::|
 Frog   549 NTPGTRVNRYIGRLIEA-RQTDSEMSDL---NFITLKYKHIEREQKYHQLHDEYFTSAVVLSLIL 609

  Fly   589 A--WGIGCCLIYIQ--IVNDKFTICVECIVIDMVVFTFLTSLLFISWFKKVCWWRCVENDSRKYG 649
            |  :|:...||:.|  ||......|: |.::..:::..:|
 Frog   610 AALFGLVYLLIFPQSTIVLILLVFCL-CFLVACIMYLHVT------------------------- 648

  Fly   650 RVSCKLFKIWERIQHSFVLRVTIYMSIVASYYLLISTILLNC------DKNQYELDVINSK---- 704
            ||.|  |.....||    :|..:.:.||...|.:....::.|      ..|...:.:|..|
 Frog   649 RVQC--FPGCLTIQ----IRTILCIFIVILIYSVAQGCVVGCMPWIWRSNNSSSIVIITPKGENK 707

  Fly   705 --------LYHYDIVTDNCFNPWVFTDMISLIVGV--SYTFARIPFALKMLITCCATVAYLVIVF 759
                    ..||              ..:|.:||.  ...|.||....||::....|:.|:||:
 Frog   708 TMNERPCDTAHY--------------TFLSCVVGTLSLAIFLRISSFPKMVLLLFVTILYIVIL- 757

  Fly   760 FQYSFIFEHSATTTPFMKAE---LAHCLRVCMMLLTMYAKERQSEFNTKINFKINQD----LQGK 817
             :.|...:.....|.:|:..   ||..|..|.:.|          .:.:::.|:..|    :|.:
 Frog   758 -EISGYRKTLGGDTSYMRGYEPILAILLFSCSLAL----------HSRQVDLKLRLDYLWAVQAE 811

  Fly   818 QKAAD-----ITNKSIIILLTNILPSHVVEVYL-DSVANHELYYENYKMVSVMFAMLINF----- 871
            ::..|     :.||.|   |.|:||:||.:.:| .:..|.:|||::|..|.||||.:.||
 Frog   812 EERDDMERVKLDNKRI---LFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYI 873

  Fly   872 -----QMDLPSLRVLNDIITEFDRLLNAYKEYYV-VEKIKVVGCTYMAACGLDFTLAKSKFGSRT 930
                 .|.:..||:||:||.:||.|:.  ||.|. :||||.:|.|||.|.||..|.     |::.
 Frog   874 ELDGNNMGVECLRLLNEIIADFDELME--KECYKDIEKIKTIGSTYMGAVGLVPTT-----GTKA 931

  Fly   931 HASYSSELEQVLYRKESKGTENDHDEVAFIMTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICI 995
            ..|..|.|.                    .:..|::::..||...|.        ::.:...:.:
 Frog   932 KKSIYSHLS--------------------TLADFSIEMFDVLDEINY--------QSYNEFVLRV 968

  Fly   996 GISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTQETANILE--QFDIMCMYRGM 1058
            ||:.|.::|||:||.:|.||||||.||:||||:|||:.|.|.||::...||:  .::.:|  ||.
 Frog   969 GINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGKIQVTEDVHRILKSCNYEFVC--RGK 1031

  Fly  1059 TFVKGRGEIPTYFVGIDDNLKFLPSNVKKNNMSKR 1093
            ..|||:||:.|||  ::..:....|..:..|:.::
 Frog  1032 VSVKGKGEMLTYF--LEGKIDGTNSQTRSLNLERK 1064

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	53/290 (18%)
		CYCc	249..459	CDD:214485	84/212 (40%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	81/185 (44%)
		CYCc	825..1047	CDD:214485	84/233 (36%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	84/231 (36%)
adcy1	XP_002933461.1	AC_N	<37..282	CDD:292831	59/315 (19%)
		CYCc	248..443	CDD:214485	83/212 (39%)
		Guanylate_cyc	284..466	CDD:278633	81/183 (44%)
		CYCc	817..1028	CDD:214485	85/248 (34%)
		Guanylate_cyc	850..1047	CDD:278633	85/235 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910