DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXB and gucy1a2

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	XP_009290254.2	Gene:	gucy1a2 / 100330875	ZFINID:	ZDB-GENE-121023-3	Length:	608	Species:	Danio rerio

Alignment Length:	281	Identity:	75/281 - (26%)
Similarity:	133/281 - (47%)	Gaps:	45/281 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 HQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSIKERIMLSETDSDRIVVNARRTENFMAIQ 301
            ||.|:||      :::...||.||.|..:|:.:.|.:.              |.|::.:
Zfish   355 HQALEEE------KRRTVDLLYSIFPGDVAQRLWQGLP--------------VQAKKFD------ 393

  Fly   302 IHPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVAGLGE 366
               ||::|::|:|.:|.:....|..:::.:|::||.|||.......|.:|:.:||.|....||..
Zfish   394 ---DVTMLFSDIVGFTAVCAQCTPMQVISMLNELYTRFDYQCGILDVYKIETIGDAYCVAGGLHR 455

  Fly   367 ADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIAN 431
            ....||:....:.:.|:...:||.......|.:|||:|||::||||:|....:|.::|.:|.:|:
Zfish   456 KIDSHAKPIALMALKMMELSEEVLTPDGKPIKLRIGIHSGSVLAGVVGVMMPRYCLFGNNVTLAS 520

  Fly   432 RLEATGKPGYVHVSGRTLSSL-NVAEYTVFPGTEVAQSDPILQKQPMTTYLLTAAPSRNSVRSVD 495
            :.|:...|..::||..|...| :...:|..|.:.....|...::.|...|.|.|..|:
Zfish   521 KFESGSHPRCINVSPTTYQLLRDDRSFTFIPRSRQELPDNFPKEIPGICYFLEAGKSQ------- 578

  Fly   496 AVHSYAEIDINALGASRKSPI 516
               |:|     :|.::|.:||
Zfish   579 ---SHA-----SLTSTRSAPI 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	12/38 (32%)
		CYCc	249..459	CDD:214485	56/210 (27%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	53/186 (28%)
		CYCc	825..1047	CDD:214485
		Nucleotidyl_cyc_III	853..1072	CDD:299850
gucy1a2	XP_009290254.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900