Protein Alignment ACXB and adcy8

DIOPT Version :10

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: NP_001137224.1
• Gene: adcy8 / 100148976
• ZFINID: ZDB-GENE-070912-197
• Length: 1225
• Species: Danio rerio
• Alignment Length: 1026
• Identity: 286/1026 - (27%)
• Similarity: 455/1026 - (44%)
• Gaps: 228/1026 - (22%)

  Fly   148 YDVFVLCMIYMFLPIPSIRGAALLATSVSLMYIGLFIYFLKSDDEDISEVVHDLDTICVDIFHYL 212
            |.:|.|...|..||:| :..|.:.....|.::|.|  ..|......||     .:.:...:..:|
Zfish   247 YVLFTLFATYSMLPLP-LTWAIVAGLLTSALHIAL--QLLVPPRAQIS-----TNQLLAQVLLFL 303

  Fly   213 GFNLMGIFFRIMNDTMVRSSFLDRHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSIKERI 277
            ..|..|:|...::|...|.:||:..:.::..:.|....|::..|:.|:||             |.
Zfish   304 CINTAGMFISYLSDRAQRQAFLETRRCIEARLRLETENQRQERLVLSVLP-------------RF 355

  Fly   278 MLSETDSDRIVVNARRTEN-FMAIQIH--PDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRF 339
            ::.|..:|...|.....:: |..|.||  .:||||:|||..:|:|:|||:.::||::|::|:.||
Zfish   356 VVLEMINDMTNVEDETLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARF 420

  Fly   340 DMAASTFKVQRIKFLGDCYYCVAGLGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVH 404
            |..|......|||.||||||||:||.|..||||...|.:|:|||..|:.||:....|||||||:|
Zfish   421 DRLAHEHHCLRIKILGDCYYCVSGLPEPRPDHAHCCVEMGLSMIKTIRYVRSRTKHDIDMRIGIH 485

  Fly   405 SGTLLAGVIGQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSD 469
            ||::|.||:|..|.|:|:|..||||||:||:.|.||.:|:|...|..|| .:|.|..|....::|
Zfish   486 SGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKAALDCLN-GDYEVEEGHGKDRND 549

  Fly   470 PILQKQPMTTYL-------LTAAPS---RNSVRSVDAVHSYAEIDI------------------N 506
             .|::..:.|:|       |...|.   |:|....|  |..:....                  |
Zfish   550 -FLRRHNIETFLIKQPEESLLTLPEDIMRDSTNQSD--HRTSNTSFTEGTWSPELPFHNIVGKQN 611

  Fly   507 ALGA-SRKSPILRPTLMSDELR-----EEFKKMPVGGFNIRSPCCRDNSNDEKVNHGLGMFCVAF 565
            .|.| :|.|..|.|..::..|.     :|..........:|       |.|:.....:..|.:.|
Zfish   612 TLAALTRHSINLLPNHLAQALHVRAGSQEINARMQSTIALR-------SGDKLRQEHISPFSLTF 669

  Fly   566 KDSSLEWSYLHKPD-------------------------------FILKYSVLLAWGIGCCLIYI 599
            :::.||..|....|                               .::::|||:.  :.|||:.:
Zfish   670 REALLEHKYSQMRDEVFKSNLVCAFIVLFFITGIQSLLPSARMVTMLIQFSVLIL--LHCCLVVV 732

  Fly   600 QIVNDKFTICVECIVIDMVVFTFLTSLLFISWFKKVCWWRCVENDSRKYGRVSCKLFKIWERIQH 664
            ....|     .:|:.:.:               :|.|.|                       :..
Zfish   733 TTAED-----YKCLPLVL---------------RKACCW-----------------------VNE 754

  Fly   665 SFVLR-VTIYMSIVASYYLLISTILLNCD---KNQYELDVINSKLYHYDIVTDNCFNP--WVFTD 723
            ::..| |.|::||:.::...:..||. ||   ...:.....|:..    .:.|.||.|  :|||.
Zfish   755 TYAARNVVIFLSILINFLAAMINILW-CDFDKSGSFRNQTFNASA----SIPDICFYPEYFVFTG 814

  Fly   724 MISLIVGVSYTFARIPFALKMLITCCATVAYLVIVFFQYSFIFEHSATTT-----PFMKAELAHC 783
            :::::  ....|.|:...||:.|.......|.|:....|:.:|....|.|     .|:..:....
Zfish   815 VLAMV--TCAVFLRLNSVLKLAILLIMIAIYAVLTEAFYTPLFIRYDTLTLNQSKSFLGTKETSL 877

  Fly   784 LRVCMMLLTMYAKERQSEFNTKINFKINQDLQGKQKAADIT-----NKSIIILLTNILPSHVVEV 843
            |.:.|.||.::...:|.|:..:::|...  :|.|::..::.     |::   :|.|||||||...
Zfish   878 LLMAMFLLAVFYHGQQLEYTARLDFLWR--VQAKEEINEMRELREHNEN---MLRNILPSHVARH 937

  Fly   844 YLDSVA-NHELYYENYKMVSVMFAMLINF----------QMDLPSLRVLNDIITEFDRLLNAYKE 897
            :|:... |.|||.::|..|.||||.:..|          ...:..||:||:||.:||.||.. :.
Zfish   938 FLEKDRDNEELYSQSYDTVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGE-ER 1001

  Fly   898 YYVVEKIKVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAFI-- 960
            :..:||||.:|.||||..||                 |.|.:|.            .|:...:
Zfish  1002 FQDIEKIKTIGSTYMAVSGL-----------------SPEKQQC------------EDKWGHLCA 1037

  Fly   961 MTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMAS 1025
            :..||:.|...:...||        .:.:..::.||::.|.::|||:||.:|.|||||..||:||
Zfish  1038 LADFAIALNESIQEINK--------HSFNNFQLRIGMAHGSVVAGVIGAKKPQYDIWGKTVNLAS 1094

  Fly  1026 RMESTGLPGHIHVTQETANILEQFDIMCMYRGMTFVKG----RGEIPTYFV 1072
            ||:|||:.|.|.:.:||..||.:......|||..:|||    .|:|.|:|:
Zfish  1095 RMDSTGVSGKIQLPEETYAILNERGFAFEYRGEIYVKGISEQEGKIRTHFM 1145

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AcyC	85..452	CDD:441717	114/306 (37%)
		Nucleotidyl_cyc_III	298..484	CDD:448371	91/194 (47%)
		Nucleotidyl_cyc_III	853..1072	CDD:448371	77/234 (33%)
adcy8	NP_001137224.1	AcyC	189..541	CDD:441717	118/315 (37%)
		Guanylate_cyc	379..563	CDD:425528	90/185 (49%)
		Adcy_cons_dom	592..686	CDD:461877	18/100 (18%)
		Guanylate_cyc	948..1147	CDD:425528	78/236 (33%)