DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXB and gucy1a2

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	NP_001120379.1	Gene:	gucy1a2 / 100145454	XenbaseID:	XB-GENE-1011801	Length:	712	Species:	Xenopus tropicalis

Alignment Length:	264	Identity:	73/264 - (27%)
Similarity:	125/264 - (47%)	Gaps:	37/264 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 HQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSIKERIMLSETDSDRIVVNARRTENFMAIQ 301
            ||.|:||      :::...||.||.|..:|:.:.:...              |.||:.:
Frog   460 HQALEEE------KKKTVDLLYSIFPGDVAQQLWEGKS--------------VQARKFD------ 498

  Fly   302 IHPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVAGLGE 366
               ||::|::|:|.:|.:....|..:::.:|::||.|||.......:.:::.:||.|...|||..
Frog   499 ---DVTMLFSDIVGFTAVCAQCTPMQVISMLNELYTRFDYQCGFLDIYKVETIGDAYCVAAGLLR 560

  Fly   367 ADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIAN 431
            ....||:....:.:.|:...:||.......|.||||:|||::||||:|....:|.::|.:|.:|:
Frog   561 QSNSHAKPIALMALKMMELSEEVLTPDGRPIKMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLAS 625

  Fly   432 RLEATGKPGYVHVSGRTLSSL-NVAEYTVFPGTEVAQSDPILQKQPMTTYLLTA-------APSR 488
            :.|:...|..::||..|...| :.|.:...|.:.....|...::.|...|.|.|       .||.
Frog   626 KFESGSHPRRINVSPTTYQLLKDEANFHFVPRSREELPDNFPKEIPGICYFLEADSGQKQPKPSL 690

  Fly   489 NSVR 492
            .|||
Frog   691 TSVR 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	11/38 (29%)
		CYCc	249..459	CDD:214485	57/210 (27%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	53/186 (28%)
		CYCc	825..1047	CDD:214485
		Nucleotidyl_cyc_III	853..1072	CDD:299850
gucy1a2	NP_001120379.1	Pap_E4	30..>86	CDD:367150
		HNOB	<132..248	CDD:377902
		HNOBA	296..486	CDD:369471	11/31 (35%)
		Guanylate_cyc	492..679	CDD:306677	56/195 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910