Protein Alignment ACXB and adcy7

DIOPT Version :9

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: NP_001106549.1
• Gene: adcy7 / 100127741
• XenbaseID: XB-GENE-1005225
• Length: 1061
• Species: Xenopus tropicalis
• Alignment Length: 1125
• Identity: 332/1125 - (29%)
• Similarity: 540/1125 - (48%)
• Gaps: 184/1125 - (16%)

  Fly    40 YKKYQIRLMISYLTVFFPLFIFV--VVGCELCPWI-----FSEQ--KKLIYYESLTAIVVLVAVP 95
            |:|||.      ::..:||.:.:  |||......|     ||::  :.|.:.  :|..|.||...
 Frog    22 YEKYQC------ISQHYPLLLILLFVVGASCVTLIVLFFTFSQEPFRHLAFI--ITVFVALVVFC 78

  Fly    96 GILSINFFESFVLRHRWIMVFSSILSAYIVVLVDIFQILVFHFK--YHWPLNTLYDVFVLCMIYM 158
            .:..:.:.||||  .:|:.|||.::  ||.:|. |..:|.:...  :.|. ...:.:|:...:|.
 Frog    79 ALYILVYTESFV--QKWLRVFSLVI--YICLLT-IGYVLTYDSSVVHAWD-QVPFFLFITFSVYT 137

  Fly   159 FLPIPSIRGAALLATSVS----LMYIGLFIYFLKSDDEDISEVVHDLDTICVDIFHYLGFNLMGI 219
            .||:.  ..|.|:.:.:|    ::.|.:.:......::.|:      ..:..:...:|..||||.
 Frog   138 MLPLG--MQACLIVSIISGISHIIVISITVVLSSGSNDAIA------FQLMANAVIFLCGNLMGA 194

  Fly   220 FFRIMNDTMVRSSFLDRHQFLKEEMWLR-QARQQESMLLDSILPPQIAKPIQQSIKERIMLSETD 283
            :.:.......|..:....:.::.:|.|. :.|||||:|| |:||..|:..::.:|::|  |:||:
 Frog   195 YHKYHMQDASRDLYSYTVKCIRIKMKLELKKRQQESLLL-SVLPVYISMEMKLAIQDR--LTETN 256

  Fly   284 SDRIVVNARRTENFMAIQI--HPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTF 346
            .:|     :...||.::.:  |.:|||||||:|.:|.|.:..:.::||.:|::|:|:||..|...
 Frog   257 DNR-----QPDNNFHSLYVKRHQNVSILYADIVGFTRLASDCSPKELVVMLNELFGKFDQIAKEN 316

  Fly   347 KVQRIKFLGDCYYCVAGLGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAG 411
            :..|||.||||||||:||..:.|::|:..|.:|:.:...|::||.....||:||:|||||.:|.|
 Frog   317 ECMRIKILGDCYYCVSGLPVSLPNNAKNCVKMGLDICEAIKQVREATGADINMRVGVHSGNVLCG 381

  Fly   412 VIGQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQP 476
            |||..|.|:|:|..||.:|||:|:.|.||.||::..||..:|.| |.|..|....: ||.|::..
 Frog   382 VIGLRKWQFDVWSHDVSLANRMESAGLPGRVHITEATLKHMNGA-YDVEEGHGELR-DPYLKEMN 444

  Fly   477 MTTYLLTAAPSRNS-----------------VRSVDAVHSYAEIDINALGASR---------KSP 515
            :.|:|:....::||                 ||....:..|.|    :.||:|         .|.
 Frog   445 IKTFLVIDPRAKNSRVKNNHLTRHRVNDGIKVRPSVRMTRYLE----SWGAARPFSHFDQTDASS 505

  Fly   516 ILRPTLMSDELREEFKKMPVGGFNIRSPCCRDNS---NDEKVNHGLGMFCVAFKDSSLEWSYLHK 577
            ...||:......|    :|:.|........|:.|   |.|:..|...|..:....|:..| :...
 Frog   506 TEVPTVNGKPKPE----IPLKGMGRTVKTERNVSQKRNQEEELHDRMMNTIDGLSSAKPW-FGKT 565

  Fly   578 PDFILKYSVLL------------AWGIGCCLIYIQIVNDKFTICVECIVIDMVV--------FTF 622
            .||   |..||            .:.|.|...|....:..| :|:  .:|.::|        .:|
 Frog   566 DDF---YGFLLFFTADGLEKEYRTFRIPCIQSYFLCASLIF-LCI--FLIQILVMPRSANLGISF 624

  Fly   623 LTSLLFISWFKKVCWW-RCVE--NDSRKYGRVSCKLFKIWERIQHSFVLRVTIYMSIVASYYLLI 684
            ....:.|.|...:|:. :|..  |::..:.|..|.|.   |.|:....|||.: :::.....|:|
 Frog   625 GVVSVLILWVLLICYVDKCARFCNENAPFSRFLCSLV---EMIETRPSLRVPL-VALTLGSLLII 685

  Fly   685 STILLNCDKNQYELDVINSKLYHYDIVTDN-CFN-P-WVFTDMISLIVGVSYTFARIPFALKMLI 746
            |.:.|..|:.   |...|:.    .|.|:: |.: | :|:..::.|:  ....|.|:.|.||:|:
 Frog   686 SIVNLPLDQT---LQTCNTS----SIATESQCQSIPYYVYCCILGLV--ACSMFLRMCFELKILL 741

  Fly   747 TCCATVAYLVIVFFQYSFIFEHSATTT-----PFMKAELAHCLRVCMMLLTMYAKERQSEFNTKI 806
            ...|..||.||:|..:|.||..:..::     .|.|..   |..:.:..||:....||.|:.:::
 Frog   742 LTAAFTAYNVIIFHTHSSIFRSNLNSSIGVLEDFQKMS---CFYLSLYYLTLVLLARQVEYYSRL 803

  Fly   807 NFKINQDLQGKQKAADITNKSIIILLTNILPSHVVEVYL-DSVANHELYYENYKMVSVMFAMLIN 870
            :....:..:.:.:..:.......:||.|:||:||...:: |:.:|.:||:::|..|.||||.:..
 Frog   804 DCLWKRKFRKEDEEIETMENLNQLLLENVLPAHVAAYFIDDNRSNEDLYHQSYDCVCVMFASVPE 868

  Fly   871 FQM----------DLPSLRVLNDIITEFDRLLNAYKEYYVVEKIKVVGCTYMAACGLDFTLAKSK 925
            |::          .|..||:||:||.:||.||...| :..|||||.:|.|||||.||..|..
 Frog   869 FKVFYTECDVNKEGLECLRLLNEIIADFDELLMKPK-FSGVEKIKTIGSTYMAATGLTATPG--- 929

  Fly   926 FGSRTHASYSSELEQVLYRKESKGTENDHDEVAFIMTTFALDLMRVLSVCNKAYAGRPFDRALST 990
                               :|::..|..|..:. |...:|:.||..|...|:        .:.:.
 Frog   930 -------------------QENQDQEKQHALIG-ITVEYAMALMSKLDGINR--------HSFNN 966

  Fly   991 GEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTQETANILEQFDIMCMY 1055
            ..:.:||:.|.::|||:||.:|.||||||.||:||||||||..|.|.||:||..|||.....|..
 Frog   967 FRLRVGINHGPVIAGVIGAKKPQYDIWGNTVNVASRMESTGELGKIQVTEETCQILEGLGYSCEC 1031

  Fly  1056 RGMTFVKGRGEIPTYFVGID 1075
            ||...|||:||:.||||..|
 Frog  1032 RGFINVKGKGELRTYFVCTD 1051

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	60/251 (24%)
		CYCc	249..459	CDD:214485	92/211 (44%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	80/187 (43%)
		CYCc	825..1047	CDD:214485	85/232 (37%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	88/228 (39%)
adcy7	NP_001106549.1	AC_N	<21..266	CDD:318454	66/273 (24%)
		Guanylate_cyc	268..418	CDD:306677	68/149 (46%)
		DUF1053	483..591	CDD:399378	25/119 (21%)
		Guanylate_cyc	851..1048	CDD:306677	88/228 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020