DRSC/TRiP Functional Genomics Resources

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Protein Alignment ACXE and Phlpp1

DIOPT Version :9

Sequence 1:NP_652601.3 Gene:ACXE / 53426 FlyBaseID:FBgn0040506 Length:1123 Species:Drosophila melanogaster
Sequence 2:NP_598582.3 Gene:Phlpp1 / 98432 MGIID:2138327 Length:1687 Species:Mus musculus


Alignment Length:326 Identity:60/326 - (18%)
Similarity:121/326 - (37%) Gaps:88/326 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   837 HI--VDVYLNSLAKHELYFENYRMVSVMFAMLINFEMDLRSLRVLNEIIAEFDTLLLFYKEYYTV 899
            ||  ||:.||.|.|             :.|..::|...:..|.:.:..:.:.|.::....|....
Mouse   764 HIKHVDLRLNILRK-------------LMADEVDFVQHVTQLDLRDNKLGDLDAMIFNNIEVLHC 815

  Fly   900 EKIKIVGCTYMAACGLDLN--FAGS-------------------TSTNRKESIPPTEFNEEQSRR 943
            |:.::|   .:..||..|.  :|.|                   .|.|..||:|....   :||:
Mouse   816 ERNQLV---TLNVCGYFLKALYASSNELAQLDVYPVPNYLSYMDVSRNCLESVPEWVC---ESRK 874

  Fly   944 ILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGA 1008
            :          ||:.:..:...::...|..::...:.:||...:......:..:|.||:      
Mouse   875 L----------EVLDIGHNQICELPARLFCNSSLRKLLAGHNRLARLPERLERTSVEVL------ 923

  Fly  1009 SQPHYDIWGNPVNM-------------ASRMESTGLPGHIHVTEETSEILQQFGIT--C-SYRGM 1057
            ...|..|...|.|:             |:::|:  || ...::||||.|||:..:|  | :.:.:
Mouse   924 DVQHNQITELPPNLLMKADSLRFLNASANKLET--LP-PATLSEETSSILQELYLTNNCLTDKCV 985

  Fly  1058 TFVKGRGKIPTYLVGIDENLNFIPQKATRFPSHQE-----------RSTVISLQSTYTHAENNNS 1111
            ..:.|..::....:..:...:|...|..:....:|           .:|:::.:..:|...::|.
Mouse   986 PLLTGHPRLKILHMAYNRLQSFPASKMAKLEELEEIDISGNKLKAIPTTIMNCRRMHTVIAHSNC 1050

  Fly  1112 I 1112
            |
Mouse  1051 I 1051

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXENP_652601.3 AC_N <31..272 CDD:318454
Nucleotidyl_cyc_III 290..459 CDD:325147
Nucleotidyl_cyc_III 851..1071 CDD:325147 45/256 (18%)
Phlpp1NP_598582.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..96
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 230..406
PH_PHLPP-like 491..587 CDD:270131
PH 511..592 CDD:278594
LRR_RI 581..885 CDD:238064 29/149 (19%)
LRR_8 594..659 CDD:290566
LRR 1 594..615
leucine-rich repeat 597..617 CDD:275380
LRR 2 617..638
leucine-rich repeat 618..648 CDD:275380
LRR_8 647..726 CDD:290566
LRR 3 648..669
LRR 4 671..692
leucine-rich repeat 672..694 CDD:275380
LRR 5 694..715
leucine-rich repeat 695..717 CDD:275380
LRR 6 717..739
leucine-rich repeat 718..740 CDD:275380
LRR 7 740..760
leucine-rich repeat 741..764 CDD:275380 60/326 (18%)
LRR 8 764..785 9/33 (27%)
LRR_RI 768..1030 CDD:238064 54/299 (18%)
leucine-rich repeat 768..788 CDD:275380 8/32 (25%)
LRR 9 788..809 2/20 (10%)
leucine-rich repeat 789..809 CDD:275380 2/19 (11%)
leucine-rich repeat 810..851 CDD:275380 8/43 (19%)
LRR 10 829..850 3/20 (15%)
LRR 11 851..872 5/23 (22%)
leucine-rich repeat 852..874 CDD:275380 6/24 (25%)
LRR 12 874..895 3/30 (10%)
leucine-rich repeat 875..897 CDD:275380 3/31 (10%)
LRR_8 896..954 CDD:290566 10/63 (16%)
LRR 13 897..918 2/20 (10%)
leucine-rich repeat 898..919 CDD:275380 2/20 (10%)
LRR 14 919..940 7/26 (27%)
leucine-rich repeat 920..943 CDD:275380 6/28 (21%)
LRR 15 943..964 4/23 (17%)
leucine-rich repeat 944..967 CDD:275380 6/25 (24%)
LRR 16 969..989 5/19 (26%)
LRR_8 970..1028 CDD:290566 8/57 (14%)
leucine-rich repeat 970..993 CDD:275380 5/22 (23%)
LRR 17 993..1014 2/20 (10%)
leucine-rich repeat 994..1017 CDD:275380 2/22 (9%)
LRR 18 1017..1038 2/20 (10%)
LRR 19 1040..1061 3/12 (25%)
LRR 20 1062..1083
leucine-rich repeat 1063..1085 CDD:275380
LRR 21 1085..1106
PP2Cc 1124..1376 CDD:214625
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1414..1465
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1604..1687
PDZ-binding 1685..1687
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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