DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXE and CYR1

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_012529.3	Gene:	CYR1 / 853452	SGDID:	S000003542	Length:	2026	Species:	Saccharomyces cerevisiae

Alignment Length:	788	Identity:	149/788 - (18%)
Similarity:	273/788 - (34%)	Gaps:	273/788 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   442 NNLDVNRFD-IEDGPEEARD--HPLLKKYRIRSYIIRQDLHMDDEDSDEFL--GDLHS--ISLCN 499
            :::|.:..| :..||...:|  |                 |.|.:|::..:  ||.:|  :.:|
Yeast   486 SSIDADELDPMSPGPPSKKDSRH-----------------HHDRKDNESMVTAGDSNSSFVDIC- 532

  Fly   500 MGAQPRISDSANQSLRALFHEELREEFRKMPVS-AFSPKRLLG-ICRFNTGKEVP----AHQNLN 558
               :..:.:.:..:|.......|:......|.| .::|..|.| ....:|...:|    :.::.:
Yeast   533 ---KENVPNDSKTALDTKSVNRLKSNLAMSPPSIRYAPSNLDGDYDTSSTSSSLPSSSISSEDTS 594

  Fly   559 IC---LTFTD-------------PILERAYLKQTDYMYKYSIILSASVGCS---------LVYIE 598
            .|   .::|:             |||.    |...|..|::   |:||..:         |:..:
Yeast   595 SCSDSSSYTNAYMEANREQDNKTPILN----KTKSYTKKFT---SSSVNMNSPDGAQSSGLLLQD 652

  Fly   599 LMDTQMICSSCFVLPASVATIQCILALIAWYKKYCWTRYGRNNVPHHYNGFSCFIFRIHDKILNS 663
            ..|.::.|                                  .:.|:|..||....:.|
Yeast   653 EKDDEVEC----------------------------------QLEHYYKDFSDLDPKRH------ 677

  Fly   664 LPIRICIYLFLMISSFFVMCLIVMSCQR----EEFEMAYIEERLFHYEQEAHICFHPWVTTNMLS 724
                ..|.:|....:|     ..:||..    ||...|.  :|.|:...:.:  |...:....||
Yeast   678 ----YAIRIFNTDDTF-----TTLSCTPATTVEEIIPAL--KRKFNITAQGN--FQISLKVGKLS 729

  Fly   725 LMICLTFTFAHIPIMVKTAVAIL--------------ETLAYLLLIFFQFDFVFHHSVTTNPY-- 773
            .::..|..    ||:::..:.:|              |.|:      |.|.|:| |.||.:.:
Yeast   730 KILRPTSK----PILIERKLLLLNGYRKSDPLHIMGIEDLS------FVFKFLF-HPVTPSHFTP 783

  Fly   774 ------FKSEYAHALL----ICITFLIMFVKERQIEFTNKVNFNWRVDLRKE--ENAASLTNHSI 826
                  .:||:.|..|    :....:|.:....:||..: |:.|..:.|..|  |::..|.:..:
Yeast   784 EQEQRIMRSEFVHVDLRNMDLTTPPIIFYQHTSEIESLD-VSNNANIFLPLEFIESSIKLLSLRM 847

  Fly   827 IIILNNILPSHIVDVYLNSLAKHELYFENYRMVSVMFAMLINFEMDLRSLRVLNEIIAEFDTLLL 891
            :.|..:..||:|...|  .|...||.....|.|.       |..|.|.:|.:||....|.::|..
Yeast   848 VNIRASKFPSNITKAY--KLVSLELQRNFIRKVP-------NSIMKLSNLTILNLQCNELESLPA 903

  Fly   892 FYKEYYTVEKIKIVG------------CTYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRI 944
            .:.|...::.:.:..            ||.:..  :||::      |:.:|:|       ||.:.
Yeast   904 GFVELKNLQLLDLSSNKFMHYPEVINYCTNLLQ--IDLSY------NKIQSLP-------QSTKY 953

  Fly   945 LFQQSNEDL--DEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRN---------ITDGTI------ 992
            |.:.:..:|  :::.|:.....:..:|||   |..|..|:..:.         :||..|
Yeast   954 LVKLAKMNLSHNKLNFIGDLSEMTDLRTL---NLRYNRISSIKTNASNLQNLFLTDNRISNFEDT 1015

  Fly   993 -----AIGISSGEVMAGIVGASQPHYDIWGNPVNMAS----RMESTGLPGHIHVTE----ETSEI 1044
                 |:.|....:      .|....|.:  |.||.|    :.:.:.:||.: :|:    |..|
Yeast  1016 LPKLRALEIQENPI------TSISFKDFY--PKNMTSLTLNKAQLSSIPGEL-LTKLSFLEKLE- 1070

  Fly  1045 LQQFGITCSYRGMTFVKGRGKIP------TYLVGID---ENLNFIPQKATRFPSHQERSTVISLQ 1100
            |.|..:|             ::|      |.||.:.   ..|.:||         .|.|.:.||:
Yeast  1071 LNQNNLT-------------RLPQEISKLTKLVFLSVARNKLEYIP---------PELSQLKSLR 1113

  Fly  1101 STYTHAEN 1108
            :...|:.|
Yeast  1114 TLDLHSNN 1121

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454
		Nucleotidyl_cyc_III	290..459	CDD:325147	4/17 (24%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	51/267 (19%)
CYR1	NP_012529.3	Ad_cyc_g-alpha	368..418	CDD:369912
		RA_PHLPP_like	678..776	CDD:340473	24/117 (21%)
		PLN00113	792..>1273	CDD:215061	82/390 (21%)
		leucine-rich repeat	796..817	CDD:275380	3/20 (15%)
		leucine-rich repeat	818..839	CDD:275380	7/21 (33%)
		leucine-rich repeat	840..864	CDD:275380	6/25 (24%)
		leucine-rich repeat	865..887	CDD:275380	8/28 (29%)
		leucine-rich repeat	888..910	CDD:275380	6/21 (29%)
		leucine-rich repeat	911..933	CDD:275380	1/21 (5%)
		leucine-rich repeat	934..956	CDD:275380	8/36 (22%)
		leucine-rich repeat	957..978	CDD:275380	2/20 (10%)
		leucine-rich repeat	979..1018	CDD:275380	9/41 (22%)
		leucine-rich repeat	1019..1041	CDD:275380	5/29 (17%)
		leucine-rich repeat	1042..1065	CDD:275380	5/23 (22%)
		leucine-rich repeat	1066..1088	CDD:275380	6/35 (17%)
		leucine-rich repeat	1089..1111	CDD:275380	7/30 (23%)
		leucine-rich repeat	1167..1187	CDD:275380
		leucine-rich repeat	1191..1211	CDD:275380
		leucine-rich repeat	1236..1258	CDD:275380
		leucine-rich repeat	1259..1287	CDD:275380
		PP2C	1374..1617	CDD:395385
		CYCc	1613..1825	CDD:214485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900