Protein Alignment ACXE and Adcy7

DIOPT Version :9

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: NP_445848.1
• Gene: Adcy7 / 84420
• RGDID: 619966
• Length: 1100
• Species: Rattus norvegicus
• Alignment Length: 1169
• Identity: 333/1169 - (28%)
• Similarity: 532/1169 - (45%)
• Gaps: 236/1169 - (20%)

  Fly    43 LWKSYLLT-----FFMLHIFVTSVHCALLLATIERRSIIYFDVALS-----IGCA---LVLILVL 94
            |::.|.||     ..:|.:.|....|..|:      ||::....|.     :|.|   |.|.:.|
  Rat    21 LYEKYRLTSQHGPLLLLLLLVAVATCIALV------SIVFSHEDLRRHQAVLGTAFFMLTLFVAL 79

  Fly    95 SVNFCDEFIAKHTWYMYASSIFASLTLVFADLTESIYHTYAHSWILGTFYDTYIIYMIYMFLPIH 159
            .|....|.:|:....:.|...:|.|.::.:.|........|::|....|: .:|::::|:.||:.
  Rat    80 YVLVYVECLAQRWLRVLALLTWACLMILGSVLMWDSLENEAYAWEQVPFF-LFIVFVVYVLLPLS 143

  Fly   160 FISG-AVLLA-----LLVSGLYILYFVIFIAQ---GFAQFASALFSVGGMSVDIVHYLCLNLVGI 215
            ..:. ||.:|     |||.|.....|...::.   |....|:|:..:||           |..|.
  Rat   144 TRAAIAVGVASTISHLLVFGAVTRAFKTSMSSTQLGLQLLANAVILLGG-----------NFTGA 197

  Fly   216 FYRVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQG- 279
            |::.......|..|:...:.|:.:..||..:.|::.||.|:||..||:.::..|..|:   |:|
  Rat   198 FHKHQLQDASRDLFIYTVKCIQIRRKLRVEKRQQENLLLSVLPAHISMGMKLAIIERL---KEGG 259

  Fly   280 ---------IHSWTAMERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAA 335
                     .||       :.::.|.:|||||||:|.:|.|.:..:.:.||.||::|:|:||..|
  Rat   260 DRHYTPDNNFHS-------LYVKRHQNVSILYADIVGFTRLASDCSPKELVVVLNELFGKFDQIA 317

  Fly   336 YRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVILGLSMINHIMEVRDIHGLDINMRIGVHSGNL 400
            ...:..|||.||||||||:||....|.||.|||.:||.:...|.:||:..|:||:||:|:||||:
  Rat   318 KANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDICEAIKQVREATGVDISMRVGIHSGNV 382

  Fly   401 FAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVHISGATLNNLDVNRFDIEDGPEEARDHPLLK 465
            ..||||..|.|:|:|..||::||.:|:.||||.|||:.||||:|| ..:::|||..|.|| |.||
  Rat   383 LCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLNHLD-KAYEVEDGHGEQRD-PYLK 445

  Fly   466 KYRIRSYIIRQDLHMDDEDSDEFLGDLHSISLCNMGAQPRI-----SDSANQSLRALFHEE---- 521
            :..||:|::..............|......:...|.|..|:     |..|.:....|.|.|
  Rat   446 EMNIRTYLVIDPRSQQPPLPSHHLSKPKGDATLKMRASVRVTRYLESWGAARPFAHLNHRESVSS 510

  Fly   522 ---------------LREEFRKMPVSAFSPK-RLLGICRFNTGKEVPAHQNLNICLTFTD----- 565
                           ||.  .:.|..:.||| ||...|.......:....:...|.:.:|
  Rat   511 SEIPIPNGRRQKAIPLRR--HRAPDRSASPKGRLEDDCDDEMLSAIEGLSSTRPCCSKSDDFHTF 573

  Fly   566 -PI-LERAYLKQTDYMYKYSIILSA--SVGC-SLVYIELMDTQMICSSCFVLP------ASVATI 619
             || ||:.:.::    |:...|..|  ...| |||::.::...::     |:|      .|...:
  Rat   574 GPIFLEKGFERE----YRLVPIPRARYDFACASLVFVCILLVHLL-----VMPRMATLGLSFGLV 629

  Fly   620 QCILALIAWYKKYCW-TRYGRNNVPHHYNGFSCFIFR-----IHDKILNSLPIRICIYLFLMISS 678
            .|:|.|:.   .:|: |.:.|           |...|     |.:.:.....:|:.: :.:.:.|
  Rat   630 ACLLGLVL---SFCFATEFSR-----------CLPARSTLQAISESVETQPLLRLSL-VVVTVGS 679

  Fly   679 FFVMCLIVMSC-------QREEFEMAYIEERLFHYEQEAHIC-FHPWVTTN-MLSLMICLTFTFA 734
            ...:.:|.|..       |..:.|.:.:..|    .:....| ..|:.|.: :|..:.|  ..|.
  Rat   680 LLTVAIINMPLTFNPGPEQPGDNETSPLAAR----NRVGTPCELLPYYTCSCVLGFIAC--SVFL 738

  Fly   735 HIPIMVKTAVAILETLAYLLLIFFQFDF-----VFHHSVTTNPYFK---------SEYAHALLI- 784
            .:.:.:|..:..:..:|||||    |:.     |..:|..||...:         |..:|.|.:
  Rat   739 RMSLELKAMLLTVALVAYLLL----FNLSPCWQVSGNSTETNSTHRTRRLLSAEQSMNSHTLALG 799

  Fly   785 ----------CIT---------FLIMF-----VKERQIEFTNKVNFNWRVDLRKEENAASLTNHS 825
                      |:.         :|::|     :..|||::..:::..|:...:||........:.
  Rat   800 AQMTAPSPSSCLERDLKTMINFYLVLFYATLILLSRQIDYYCRLDCLWKKKFKKEHEEFETMENV 864

  Fly   826 IIIILNNILPSHIVDVYLNSLAKHELYFENYRMVSVMFAMLINFEM----------DLRSLRVLN 880
            ..::|.|:||:|:...::...|..:.|.::|..|.||||.:.:|::          .|..||:||
  Rat   865 NRLLLENVLPAHVAAHFIGDKAAEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLN 929

  Fly   881 EIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRIL 945
            ||||:||.|||..| :..|||||.:|.|||||.||              |:|....|::..|:.:
  Rat   930 EIIADFDELLLKPK-FSGVEKIKTIGSTYMAAAGL--------------SVPSGHENQDLERKHV 979

  Fly   946 FQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQ 1010
            .          :.|:..:::.:|..|...|.        .:.....:.:||:.|.|:||::||.:
  Rat   980 H----------IGVLVEFSMALMSKLDGINR--------HSFNSFRLRVGINHGPVIAGVIGARK 1026

  Fly  1011 PHYDIWGNPVNMASRMESTGLPGHIHVTEETSEILQQFGITCSYRGMTFVKGRGKIPTYLVGID 1074
            |.||||||.||:||||||||..|.|.|||||..|||..|.:|..||:..|||:|::.||.|..|
  Rat  1027 PQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCTD 1090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	60/250 (24%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	84/168 (50%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	89/229 (39%)
Adcy7	NP_445848.1	AC_N	<21..251	CDD:318454	59/247 (24%)
		Guanylate_cyc	272..422	CDD:306677	74/149 (50%)
		DUF1053	487..593	CDD:399378	22/111 (20%)
		Guanylate_cyc	891..1087	CDD:306677	89/228 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.880