Protein Alignment ACXE and Adcy2

DIOPT Version :9

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: NP_112269.2
• Gene: Adcy2 / 81636
• RGDID: 619965
• Length: 1095
• Species: Rattus norvegicus
• Alignment Length: 1214
• Identity: 330/1214 - (27%)
• Similarity: 536/1214 - (44%)
• Gaps: 287/1214 - (23%)

  Fly    17 MWEPGYLKAKCAELRLESEFR--------LYRIRLW--KSY--------LLTFFMLHIFVTSVHC 63
            ||:....:.:....|.|:...        |.|.|.|  :||        |:.|.:|   :....|
  Rat     1 MWQEAMRRRRYLRDRAEAAAAAAAGGGEGLQRSRDWLYESYYCMSQQHPLIVFLLL---IVMGAC 62

  Fly    64 ALLLATIERRSIIYFDVAL----------SIGCALVLILVLSVNFCDEFIAKHTWYMYASSIFAS 118
            ..|||       ::|.:.|          ::..||.:...:.:..|.|.:.|....:::..|:
  Rat    63 LALLA-------VFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRVFSLVIW-- 118

  Fly   119 LTLVFADLTESIYHTYAHSWILGTFYDTYIIYMIYMFLPIHFISGAVLLALLVSGLYILYFVIFI 183
            :.||........:.....:|...:|: .:||:::|..||.: :..|::.::|.|..:.:...:::
  Rat   119 ICLVAMGYLFMCFGGTVSAWDQVSFF-LFIIFVVYTMLPFN-MRDAIIASILTSSSHTIVLSVYL 181

  Fly   184 AQG-------FAQFASALFSVGGMSVDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIW 241
            :..       |.|..:          :::.::|.||.|.:::.:.:..::.::.|....||.:|.
  Rat   182 SATPGAKEHLFWQILA----------NVIIFICGNLAGAYHKHLMELALQQTYRDTCNCIKSRIK 236

  Fly   242 LRNARLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERT-----MAIQIHPDVSIL 301
            |...:.|:::||.|:||..|::.::.:|..|:...|.|     .||.|     :.::.|.:||||
  Rat   237 LEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAG-----QMENTNNFHNLYVKRHTNVSIL 296

  Fly   302 YADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANN 366
            |||:|.:|.|.:..:...||.:|::|:|:||..|...:..|||.||||||||:||....|:||.|
  Rat   297 YADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKN 361

  Fly   367 CVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVP 431
            ||.:||.|...|.:|||..|:|||||:||||||:..||||..|.|:|:|..|||:||.:|:.|||
  Rat   362 CVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVP 426

  Fly   432 GCVHISGATLNNLDVNRFDIEDGPEEARDHPLLKKYRIRSYII-------RQDLHMDDEDSDEFL 489
            |.||||..||.:|: ..:.:|:|..|.|| |.||::.:::|.:       |...|:        .
  Rat   427 GRVHISSVTLEHLN-GAYKVEEGDGEIRD-PYLKQHLVKTYFVINPKGERRSPQHL--------F 481

  Fly   490 GDLHSISLCNMGAQPRIS------------------DS--------------------ANQSLRA 516
            ...|::....|.|..|::                  ||                    .|::||.
  Rat   482 RPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRT 546

  Fly   517 -----LFHEELREEFRKMPVSAFSPKRLLGICRFNTGKEVPAHQNL-NICLTFTDPILERAYLKQ 575
                 .|.|||.|            :.:..|...|..|:....::: .|.|.|.:..:|:.|...
  Rat   547 KSQKKRFEEELNE------------RMIQAIDGINAQKQWLKSEDIQRISLLFYNKNIEKEYRAT 599

  Fly   576 TDYMYKYSI----------------------ILSASVGCSLVYIELMDTQMICSSCFVLPASVAT 618
            ....:||.:                      ||..|.|.:  ::.|:....:|.:..:|..|...
  Rat   600 ALPAFKYYVTCACLIFLCIFIVQILVLPKTSILGFSFGAA--FLSLIFILFVCFAGQLLQCSKKA 662

  Fly   619 IQCILALIAWYKKYC-------WTRYGRNNVPHH-------YNGFSCFIFRIHDKIL-------- 661
            ...::    |..|..       |.|.....|...       :|.|  |:....:..|
  Rat   663 STSLM----WLLKSSGIIANRPWPRISLTIVTTAIILTMAVFNMF--FLSNSEETTLPTANTSNA 721

  Fly   662 ------NSLPIRICIYLFLMISSFFVMCLI-VMSCQ---REEFEMAYIEERLFHYEQEAHICFHP 716
                  |...|.....|| .:..|...|:: ::||.   |..:|:
  Rat   722 NVSVPDNQASILHARNLF-FLPYFIYSCILGLISCSVFLRVNYEL-------------------- 765

  Fly   717 WVTTNMLSLMICLTFTFAHIPIMVKTAVAILETLAYLLLIFFQFDFVFHHSVTTNPYFKSEYAHA 781
                .||.:|:.|.   .:..|::.|...:|:..:.:|   ||...::....|..         :
  Rat   766 ----KMLIMMVALV---GYNTILLHTHAHVLDAYSQVL---FQRPGIWKDLKTMG---------S 811

  Fly   782 LLICITFLIMFVKERQIEFTNKVNFNWRVDLRKEENAASLTNHSIIIILNNILPSHIVDVYL-NS 845
            :.:.|.|:.:.|..||.|:..:::|.|:...:||........:...::|.|:||:|:.:.:| .|
  Rat   812 VSLSIFFITLLVLGRQSEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARS 876

  Fly   846 LAKHELYFENYRMVSVMFAMLINF-----EMD-----LRSLRVLNEIIAEFDTLLLFYKEYYTVE 900
            |...|||.::|..|.||||.:.:|     |.|     |..||:||||||:||.||...| :..||
  Rat   877 LKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPK-FSGVE 940

  Fly   901 KIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLDEVVFVMTSYAL 965
            |||.:|.|||||.||             .:||..|..:|..|:.:.          :..|..:|.
  Rat   941 KIKTIGSTYMAATGL-------------SAIPSQEHAQEPERQYMH----------IGTMVEFAY 982

  Fly   966 DMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTG 1030
            .::..|...|:        .:..|..:.:||:.|.|:||::||.:|.||||||.||:||||:|||
  Rat   983 ALVGKLDAINK--------HSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTG 1039

  Fly  1031 LPGHIHVTEETSEILQQFGITCSYRGMTFVKGRGKIPTYLVGID 1074
            :...|.||||||.|||..|.||:.||:..|||:|.:.||.|..:
  Rat  1040 VLDKIQVTEETSLILQTLGYTCTCRGIINVKGKGDLKTYFVNTE 1083

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	54/275 (20%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	85/168 (51%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	93/229 (41%)
Adcy2	NP_112269.2	AC_N	<37..264	CDD:318454	47/250 (19%)
		Guanylate_cyc	285..469	CDD:306677	91/185 (49%)
		DUF1053	499..603	CDD:399378	18/115 (16%)
		Guanylate_cyc	882..1081	CDD:306677	93/230 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880