DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXE and Gucy1a2

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_076446.1	Gene:	Gucy1a2 / 66012	RGDID:	621655	Length:	730	Species:	Rattus norvegicus

Alignment Length:	351	Identity:	83/351 - (23%)
Similarity:	137/351 - (39%)	Gaps:	115/351 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 HQYIKEKIWLRNARLQEKQLLDSILPPQISLPL--QKDIQGRIVMAKQGIHSWTAMERTMAIQIH 295
            ||.::|:      :.:...||.||.|..::..|  ::.:|.|                     ..
  Rat   478 HQALEEE------KKKTVDLLYSIFPGDVAQQLWQRQQVQAR---------------------KF 515

  Fly   296 PDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPD 360
            .||::|::|:|.:|.:....|...::.:|::||.|||.......:.:::.:||.|...:||....
  Rat   516 DDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVASGLHRKS 580

  Fly   361 PDHANNCVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVL 425
            ..||....::.|.|:....||....|..|.||||:|||::.|||:|....::.::|.:||:|:..
  Rat   581 LCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKF 645

  Fly   426 ESTGVPGCVHISGATLNNLDVNRFDIEDGPEEARDHPLLKKYRIRSYIIRQDLHMDDEDSDEFLG 490
            ||...|..::||..|                    :.|||:                |||..|:
  Rat   646 ESGSHPRRINISPTT--------------------YQLLKR----------------EDSFTFI- 673

  Fly   491 DLHSISLCNMGAQPRISDSANQSLRALFHEELREEFRKMPVSAFSPKRLLGICRF---NTGKEVP 552
                         ||            ..|||.:.|         ||.:.|:|.|   .||.:.|
  Rat   674 -------------PR------------SREELPDNF---------PKEIPGVCYFLELRTGPKPP 704

  Fly   553 AHQNLNICLTFTDPILERAYLKQTDY 578
                        .|.|..:.:|:..|
  Rat   705 ------------KPSLSSSRIKKVSY 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	10/40 (25%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	47/168 (28%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147
Gucy1a2	NP_076446.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53
		HNOB	<157..268	CDD:285002
		HNOBA	314..501	CDD:285003	8/28 (29%)
		CYCc	483..672	CDD:214485	62/251 (25%)
		Guanylate_cyc	512..696	CDD:278633	66/275 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810