Protein Alignment ACXE and Adcy5

DIOPT Version :10

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: NP_072122.2
• Gene: Adcy5 / 64532
• RGDID: 71014
• Length: 1262
• Species: Rattus norvegicus
• Alignment Length: 1174
• Identity: 322/1174 - (27%)
• Similarity: 529/1174 - (45%)
• Gaps: 229/1174 - (19%)

  Fly     4 SLGNC-----QLNYSKERMWEPGYLKAKCAELRLESEFRLYRIRLWKSYLLTFFMLHIFVTSVHC 63
            |||.|     |:..||           |....:||..::.|..||.:|.|.....:.:.|    |
  Rat   205 SLGACCLALLQIFRSK-----------KFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLV----C 254

  Fly    64 ALLLATIERR---SIIYFDVALSIGCALVLILVLSVNFCDEFIAKHTWYMYASSIFASLTLVFAD 125
            .::||....|   .::|..|   :..|:.:||:::| .|:. .|.|..:| ..:.:|.:.:|.|.
  Rat   255 LVMLAFHAARPPLQVVYLAV---LAAAVGVILIMAV-LCNR-AAFHQDHM-GLACYALIAVVLAV 313

  Fly   126 LTESIYHTYAHSWILGTFYDTYIIYMIYMFLPIHFISGAVLLALLVSGLYILYFVIFIAQGFAQF 190
            ....:......|...|.::..:.||.||..||:. :..|||..:|:|.|:       :|......
  Rat   314 QVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVR-MRAAVLSGVLLSALH-------LAISLHTN 370

  Fly   191 ASALFSVGGMSVDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLDS 255
            |...|.:..:..:::.:.|.|:||:......:...|.:|.:..:.|:.::..:....|:::||.|
  Rat   371 AQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLS 435

  Fly   256 ILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSILYADVVNYTHLTTTLTVEML 320
            :||..:::.::.||.     |||.    ..|...:.||.|.:||||:||:..:|.|.:..|.:.|
  Rat   436 VLPRHVAMEMKADIN-----AKQE----DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQEL 491

  Fly   321 VKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVILGLSMINHIMEVRDIH 385
            |..|::|:.|||..|......|||.||||||||:||.:...|||:.||.:|:.||..|..||::.
  Rat   492 VMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVT 556

  Fly   386 GLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVHISGATLNNLDVNRFD 450
            |:::|||:|:|||.:..||:|..|.|||:|..|||:||.:|:.|..|.:||:.||||.|: ..::
  Rat   557 GVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLN-GDYE 620

  Fly   451 IEDGPEEARDHPLLKKYRIRSYIIRQDLHMDDEDS----------------------------DE 487
            :|.|....| :..||::.|.:::|.:......|:.                            :.
  Rat   621 VEPGCGGER-NAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNH 684

  Fly   488 FLGDLHSISLCNMGAQPRISDSANQSLRALFHEELREEFRKMPVSAFSPKRLLG--ICRFNTGKE 550
            ..|:..|..:..||.:.....:|.:|...   |:..:||....:.|.|..||..  :.:|
  Rat   685 LGGNQVSKEMKRMGFEDPKDKNAQESANP---EDEVDEFLGRAIDARSIDRLRSEHVRKF----- 741

  Fly   551 VPAHQNLNICLTFTDPILERAYLKQTDYMYKYSIILSASVGC-SLVYIELMDTQM---------- 604
                     .|||.:|.||:.|.||.|..:      .|.|.| |||::.:...|:
  Rat   742 ---------LLTFREPDLEKKYSKQVDDRF------GAYVACASLVFLFICFVQITIVPHSLFML 791

  Fly   605 -ICSSCFVLPASVATIQCILALIAWYKKYCWTRYGRNNVPHHYNGFSCFIFRIHDKILNSLPIRI 668
             ...|||:|.|.|..|..|.|.:..:.....| ..|..|....|.....:|.|           .
  Rat   792 SFYLSCFLLLALVVFISVIYACVKLFPTPLQT-LSRKIVRSKKNSTLVGVFTI-----------T 844

  Fly   669 CIYLFLMISSFFVMCLIVMSCQREEFEM-------AYIEERLFHYE--QEAHICFHPWVTTN--- 721
            .::|...::.|......::.|..||..:       .::.|..|:|.  .|...|..|....|
  Rat   845 LVFLSAFVNMFMCNSKNLVGCLAEEHNITVNQVNACHVMESAFNYSLGDEQGFCGSPQSNCNFPE 909

  Fly   722 ------MLSLMICLTFTFAHIPIMVKTAVAILETLAYLLLIFFQFDFVFHHS---VTTNPYFKSE 777
                  :|||:.|  ..|..|..:.|..:.:...|.|:|::......:|.::   ||.|....|.
  Rat   910 YFTYSVLLSLLAC--SVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFSN 972

  Fly   778 YA------HA----------LLICITFLIMFVKERQIEFTNKVNFNWRVDLRKEENAASLTNHSI 826
            ..      ||          ::|.:..|.:::..:|:|.|.:::|.|::...:|:..........
  Rat   973 NGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYN 1037

  Fly   827 IIILNNILPSHIVDVYLNSLAKH----ELYFENYRMVSVMFAMLINF-----EMD-----LRSLR 877
            ..:|:||||.   ||..:.||:.    |||:::...|:||||.:.||     |::     :..||
  Rat  1038 RRLLHNILPK---DVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLR 1099

  Fly   878 VLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGLD---LNFAGSTSTNRKESIPPTEFNEE 939
            :||||||:||. ::....:..:||||.:|.|||||.||:   .:.||.|.
  Rat  1100 LLNEIIADFDE-IISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKAGKTH--------------- 1148

  Fly   940 QSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAG 1004
                             :..:..:|:.:|..:...||        .:..:..:.||::.|.|:||
  Rat  1149 -----------------IKALADFAMKLMDQMKYINE--------HSFNNFQMKIGLNIGPVVAG 1188

  Fly  1005 IVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEIL--QQFGITCSYRGMTFVKGRGKIP 1067
            ::||.:|.||||||.||:||||:|||:|..|.||.:..::|  ..:.:.|  ||:..|||:|::.
  Rat  1189 VIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLEC--RGVVKVKGKGEMM 1251

  Fly  1068 TYLV 1071
            ||.:
  Rat  1252 TYFL 1255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AcyC	65..453	CDD:441717	127/390 (33%)
		Nucleotidyl_cyc_III	290..459	CDD:448371	77/168 (46%)
		Nucleotidyl_cyc_III	851..1071	CDD:448371	77/234 (33%)
Adcy5	NP_072122.2	AC_N	1..459	CDD:318454	69/291 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..196
		Guanylate_cyc	461..644	CDD:425528	81/184 (44%)
		Adcy_cons_dom	669..762	CDD:461877	24/109 (22%)
		Guanylate_cyc	1063..1257	CDD:425528	77/236 (33%)