Protein Alignment ACXE and Gucy1a1

DIOPT Version :10

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: NP_068696.2
• Gene: Gucy1a1 / 60596
• MGIID: 1926562
• Length: 691
• Species: Mus musculus
• Alignment Length: 1009
• Identity: 174/1009 - (17%)
• Similarity: 311/1009 - (30%)
• Gaps: 371/1009 - (36%)

  Fly    37 RPLSGPDADLASLMEPN------ETHRLSEAEV------------NKLFLEILEDM-NIPKDKRD 82
            |.|..|...:..::.||      :|...|.|.|            |.:|||.:|.: |||
Mouse   294 RCLQSPSRPVDCVLCPNRGGAFKQTSDGSWAHVICAIWIPEVCFANTVFLEPVEGVKNIP----- 353

  Fly    83 PLLGKPLEEKRKMIDMHVKGKISSE--HRANSRFEKPSDYVQYLHEGDYLNRTNKLLACLESLRV 145
                 |...|........||:.:|.  |:||.        .:..|           :.|.:...:
Mouse   354 -----PARWKLTCYLCKQKGRGASIQCHKANC--------YRAFH-----------VTCAQRAGL 394

  Fly   146 ALTSNPISWIKDFGEDGINEIVSLLRYCKT-VPRRMHKIEYECLRCLKAILN---NSWGLNVILT 206
            .:..:|   :::.|.:|....|....||:. .|.......||....:....|   .|:.|...|.
Mouse   395 YMKIDP---VRETGTNGTTFTVKKTAYCENHSPPGTGTEGYEDNGLVGGRGNRGQRSYTLGPPLQ 456

  Fly   207 PDQH------------------------AVVLLLAQCIDTTQPHTMCEAIKL---------LSAL 238
            .:|:                        .|.|||...|.:.:.:.:|..:.:         |...
Mouse   457 QNQNGRKKGSAAQQKKTQKNSGGGSRKTGVPLLLVPQIPSFRLNKICTGVSVERKNQFMQRLHNY 521

  Fly   239 TLLK--DRNGYEKVLRAITNV----SSMRKPGAERFRPIVEGLLMDNDRNYELTCSTMIFINCII 297
            .|||  .|||...:.|..:::    |..|:|.| :.:.:.|
Mouse   522 WLLKRHSRNGVPLIRRLHSHLQAQKSEQREPDA-KLQAVRE------------------------ 561

  Fly   298 NTPTDINFRLHLRCEIMRAGLY-------ERIDQLSEMVDKCGNENLVNHIKIF-----NSYREE 350
                ::.:...||.::.:|.|.       ||:.:....:.:...|..:....:|     ...:|:
Mouse   562 ----ELKYWQKLRQDLEKARLLIELIRKRERLKREQMKLQQAALELQLTPALVFLRATLEQLKEK 622

  Fly   351 DFEEFSN------------RFDNVRLELDDMNDCFELLK-NLVADTASEPYFLSILQHLLFIRDD 402
            |.:....            .|..|.::...|:|..|..| :.|||..:: :.|.:...|.:..:|
Mouse   623 DTDHIFTTPVNLKEVPDYLEFVTVPMDFSTMHDKLEAHKYSSVADLEND-FNLMVSNCLRYNSND 686

  Fly   403 HQYRPAYFKLIEECVSQIVLHKS------GYDPN------------------FDSRDFHID---- 439
            ..:..|..:| .|....|:.|..      |.||:                  .|..|..:|
Mouse   687 TVFHKAAMQL-REVGGAILRHAQHQALSIGLDPSTGMHLPDKPIPHNTTVSWCDEVDMLLDPDNR 750

  Fly   440 --------TSTLLDDM----AEKTKQIESKKSEDFEKRMTEL--QTAKQEAEARVAALEDRLKEI 490
                    ..||||.:    :.:|....:|:.....:.:..|  :.:.|:..:|:  |..:::|.
Mouse   751 VHMCAEDQLKTLLDKLDLVASMRTSGGRTKRMRLLRREINSLRHKISHQDRNSRL--LNGKIREE 813

  Fly   491 EATGVVVSPKGKSKLPQITIPPPPPGLLPGGGPPPPPPCPGAVPVMMGGGGGGAPPPPPPPF--- 552
            ::.    ..|.:.|:..||...|...   .......|.||.:.|:      .|..||.||.|
Mouse   814 KSK----DAKSEKKMDYITSEDPKKS---ASQKAQEPACPASSPL------PGDAPPNPPLFCLE 865

  Fly   553 ------------PGA----------------------------------------AAGGPPPPPP 565
                        ||:                                        .:.......|
Mouse   866 TGRTTTPAQSNKPGSRKQRAKGKDRSLRENHNQTPKEDENFHTKENDSSPQEDRVCSAKNQSDSP 930

  Fly   566 MPGMG--------------GPPPPPPPMMMMGM---------------RPPGMPPPFPNAAPKPL 601
            ..|:|              .|....|.::..|:               :.|..|.|.     .|.
Mouse   931 KIGVGRRTSILFKKAKNGARPTKDKPVLLPNGVSKAQNGASQEQNTQAKAPSTPKPV-----SPS 990

  Fly   602 PYGLK------------------PKKKWDTDGPMKRANWNGLDAKNLSENSFWVQVQEEQLADND 648
            |:.|:                  |::...|:| :||.|.|..|::| |..:|
Mouse   991 PHQLRSRGLSTCSDGEGMKANSLPEENGLTNG-LKRHNGNSSDSEN-STPAF------------- 1040

  Fly   649 MFARLALKFSSKPAKPIDKDAADR-PQSSKKNVDLRVLDAKAAQNLSILLGGSLKHLSHEQIRTC 712
                 ....||.|.:...|.|..: |...:|| ::...:::|:||     .|.:     |.:...
Mouse  1041 -----PTHSSSPPKRSRGKPALSKVPVDEEKN-EVTNTNSEASQN-----DGEM-----EPLTLV 1089

  Fly   713 LLRC------DTSVLSPSVLQQLIQY------LPPPDQLKRLQEIRARGEDLAGAERFAATIGDI 765
            ..:|      ...::.|.:.|:.|.:      :||.|.|    ::..|.::.:..:.|.....|.
Mouse  1090 WAKCRGYPSYPAMIVDPKMPQEGILHNGIPIPVPPTDVL----DLGKRRQEESEEKLFLVLFFDT 1150

  Fly   766 KRLGARL-------QSLSFKIDLPDMVQDVKPDI 792
            ||....|       ..:...:|...:::..||::
Mouse  1151 KRTWQWLPQDKLHHMGIDDTVDRLRLMEGKKPNV 1184

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AcyC	65..453	CDD:441717	88/498 (18%)
		Nucleotidyl_cyc_III	290..459	CDD:448371	39/233 (17%)
		Nucleotidyl_cyc_III	851..1071	CDD:448371
Gucy1a1	NP_068696.2	HNOBA	277..466	CDD:462234	41/203 (20%)
		Guanylate_cyc	472..643	CDD:425528	29/199 (15%)