DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXE and Gucy1a1

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_001343916.1	Gene:	Gucy1a1 / 60596	MGIID:	1926562	Length:	691	Species:	Mus musculus

Alignment Length:	278	Identity:	78/278 - (28%)
Similarity:	136/278 - (48%)	Gaps:	42/278 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 VIFIAQGFAQFASALFSVGGMSVDIV-----HYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEK 239
            :|:|.:     :||:..:|...||.:     ..|.|:.:.| :..:.|.|:..........:|::
Mouse   370 MIYIVE-----SSAILFLGSPCVDRLEDFTGRGLYLSDIPI-HNALRDVVLIGEQARAQDGLKKR 428

  Fly   240 IWLRNARL--------QEKQ----LLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAI 292
            :....|.|        :||:    ||.||.|.:::   |:..||:||.||:
Mouse   429 LGKLKATLEHAHQALEEEKKRTVDLLCSIFPSEVA---QQLWQGQIVQAKK-------------- 476

  Fly   293 QIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLS 357
              ..:|::|::|:|.:|.:.:..:...::.:|:.||.|||.......|.:::.:||.|....||.
Mouse   477 --FSEVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLH 539

  Fly   358 DPDPDHANNCVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIA 422
            .....||....::.|.|:....||...||..|.||||:|||::||||:|....::.::|.:||:|
Mouse   540 RESDTHAVQIALMALKMMELSNEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLA 604

  Fly   423 NVLESTGVPGCVHISGAT 440
            |..||..||..:::|..|
Mouse   605 NKFESCSVPRKINVSPTT 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	24/108 (22%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	49/151 (32%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147
Gucy1a1	NP_001343916.1	HNOBA	277..466	CDD:311573	23/104 (22%)
Gucy1a1	NP_001343916.1	Guanylate_cyc	472..643	CDD:306677	52/167 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810