DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXE and gucy2ca

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	XP_009297342.1	Gene:	gucy2ca / 572052	ZFINID:	ZDB-GENE-091118-67	Length:	1025	Species:	Danio rerio

Alignment Length:	1041	Identity:	209/1041 - (20%)
Similarity:	346/1041 - (33%)	Gaps:	386/1041 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 RHQYIKEKIWLRNARLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAIQIHP 296
            :..|.:|..|..||......|..|            :|...::.::..:.  ||::|.   ..|.
Zfish   192 KDNYTEECFWYINALEAPSALFSS------------NISREMLRSESELS--TALKRK---DRHS 239

  Fly   297 DVSILYA---DVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSD 358
            ::.::..   |:  ||..........:|.:|.|||..    .||                  .::
Zfish   240 NIIVMCGTPDDI--YTIKKNNTVPSQVVFILIDLYNE----GYR------------------TNE 280

  Fly   359 PDPDHANNCVILGLSMI-----------NHIMEVRDIHGL------DINMRIGVHSGN-----LF 401
            ..|.|..|.::|.:...           |..:.:...:.|      |:|:.:...:|:     ||
Zfish   281 SSPAHMRNVLVLTMHSFRNYSSNSVWRNNTTVSIGGYYKLDSSGDRDLNLSVVYTTGSYKYRTLF 345

  Fly   402 AGVIGEAK---------LQFD--------------------IWGLDVTIANVL------ESTGV- 430
            :....:.:         |.:|                    :.||.|.:|.|:      ::..|
Zfish   346 SFDTSQNRTKVKDSSPDLPWDRSQLPRDKHTGMEIQEIMMIVLGLSVVLATVIAFILYRQNRRVR 410

  Fly   431 ---PGCVHISGATLNNLDVNRFDIE--------DGPEEARDHPLLKKYRI-RSYIIRQDLHMDDE 483
               ....|||.:.:..||    |.|        |..::..:..|::|.|. :..:|.::|...|.
Zfish   411 FDQKKWSHISSSLITPLD----DKERNYISLTIDEDKKGDNSSLIRKGRYDKKPVILKELRNTDG 471

  Fly   484 DSDEFLGDLHSISLCNMGAQPRISDSANQSLRALFHEELREEFRKMPVSAFSPKRLLGICRFNTG 548
            :                     .:|.....|.||    ||.::       ::..:..|..||:.|
Zfish   472 N---------------------FTDDQRIELNAL----LRIDY-------YNLTKFYGTVRFDCG 504

  Fly   549 K----EVPAHQNLNICL---------TFTDPILERAYLKQTDYMYKYSIILSASVGCSLVYIELM 600
            .    |.....:|...|         :|.|  ||.......|.....|.:.|::||   |:..|.
Zfish   505 VFGVFEFCERGSLRYVLDDKISYPDASFMD--LEFRISVMYDIAKGMSYLHSSNVG---VHGRLK 564

  Fly   601 DTQMICSSCFVLPASVATIQCILALIAWYKKYCWTRYGRNNVPHHYNGFSCFIFRIHDKILNSLP 665
            .|..:..:..|:..:......||:    ..|..||      .|.|..             :..:.
Zfish   565 STNCVVDNRMVVKITDFGCNTILS----PGKDLWT------APEHMR-------------VEGIS 606

  Fly   666 IRICIYLFLMISSFFVM--CLIVMSCQREEFEMAYIEERLFHYEQEAHICFHPWVTTNMLSLMIC 728
            .:..:|.|.:||...::  .....||..:..|..|    |..|.:..:: |.|           .
Zfish   607 QKGDVYSFAIISQEIILRKSPFHTSCCSDMAEKLY----LVQYPRGPNV-FRP-----------D 655

  Fly   729 LTF-----TFAHIPIMVKTAVAILETLAYLLLIFFQFDFVFHHSVTTNPYFK------------- 775
            |:|     |.|.:.:::|:.                    :.......|.||
Zfish   656 LSFEGVGETEAELFVLIKSC--------------------WEEDPEKRPDFKRIEGALGKIFSNL 700

  Fly   776 -----SEYAHALLICITFLIMFVKERQIEFTNKVNFNWRVDLR-----KEENAASLTNHSIIIIL 830
                 :.|...|:            |:::..:: |....|:.|     .|.:.|...|..
Zfish   701 HNQANASYMDNLI------------RRLQMYSR-NLEHLVEERTALYKAERDRADQLNFM----- 747

  Fly   831 NNILPSHIVDVYLNSL-----AKHELYFENYRMVSVMFAMLINF------EMDLRSLRVLNEIIA 884
              :||..:|    .||     .:.|||.|    |::.|:.::.|      ...:..:.:||:|..
Zfish   748 --LLPGPVV----RSLKETGRVEPELYDE----VTIYFSDIVGFTTICHHSTPMEVVDMLNDIYK 802

  Fly   885 EFDTLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQS 949
            .||::|    :::.|.|::.:|..||.|.||                |....|.......|.
Zfish   803 NFDSIL----DHHDVYKVETIGDAYMVASGL----------------PRCNGNRHAVDICLM--- 844

  Fly   950 NEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGT------------IAIGISSGEVM 1002
                          |||::..:                  ||            |.|||.||...
Zfish   845 --------------ALDILEFM------------------GTFQLRHLPGIPLWIRIGIHSGPCA 877

  Fly  1003 AGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEILQQFG--ITCSYRGMTFVKGRGK 1065
            ||:||...|.|.::|:.||.||||||||||..|||:|.|.:|||:..  ..|..||.||:||:||
Zfish   878 AGVVGNKMPRYCLFGDTVNTASRMESTGLPLRIHVSESTIKILQRTDCEFECERRGETFLKGKGK 942

  Fly  1066 IPTY-LVGID------------ENLNFIPQK-ATRFPS------HQERSTVISLQ-STYTHAENN 1109
            ..|| |.|:.            ||...:.|. |.|..|      ::.|.|:.:.| .|:||...:
Zfish   943 EMTYWLTGVTGQKYSLPTPPTVENFQRLQQDLAERIVSTLNKRGNERRKTLSTRQRRTHTHIHTH 1007

  Fly  1110 N 1110
            :
Zfish  1008 S 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	8/39 (21%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	38/240 (16%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	72/240 (30%)
gucy2ca	XP_009297342.1	Periplasmic_Binding_Protein_Type_1	31..365	CDD:299141	34/213 (16%)
		PKc_like	428..698	CDD:304357	63/369 (17%)
		Pkinase_Tyr	451..689	CDD:285015	58/333 (17%)
		CYCc	736..929	CDD:214485	70/262 (27%)
		Guanylate_cyc	763..950	CDD:278633	74/245 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000