DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXE and adcy3a

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	XP_009290286.1	Gene:	adcy3a / 571825	ZFINID:	ZDB-GENE-111027-6	Length:	1119	Species:	Danio rerio

Alignment Length:	1208	Identity:	319/1208 - (26%)
Similarity:	533/1208 - (44%)	Gaps:	211/1208 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPRSLGNCQLNYSKERM--------WEPGYLKAKCAELRLESEF------RLYRI--------RL 43
            |||:....:..||.|..        .:||....:..|:.:.|..      |..|:        .|
Zfish     1 MPRNRAFSEPEYSAEYSADCSVTLPSDPGQAVGRTHEVTVRSSGCCLCLPRFMRLTFAPDSLENL 65

  Fly    44 WKSYLL-----TFFMLHIFVTSVHCALL-----LATIERRSIIYFDVALSIGCALVLILVLSVNF 98
            :::|..     |..:|.:|.....|.::     |.|.::.:.:   ...|:|.|..::|.|...:
Zfish    66 YQTYFRRQRHETLLVLVVFAALFDCYIIVMCTVLYTADKLASV---AVASVGLAADVLLYLLCRY 127

  Fly    99 -------CDEFIAKHTWYMYASSIFASLTLVFADLTESIYHTYAHSWILGTFYDTYIIYMIYMFL 156
                   ....:....|.:.|:.||..|.|.||.     :|..:.:  :|  :..:..:..::.|
Zfish   128 GLLPDRVTRRLVPYALWVLIAAQIFCYLGLNFAR-----FHQPSDT--VG--WQAFFSFSFFLTL 183

  Fly   157 PIHFISGAVLLALLVSGLYILYFVIFIAQGFAQFASALFSVGGMSVDIVHYLCLNLVGIFYRVMN 221
            |:. ::..||:..:..|::.|...:.|||...:..........:..::|.|:|...||:....|.
Zfish   184 PLR-LTPIVLITSVSCGVHTLVLGVTIAQQQQEDIQGAALGRQLLANMVIYVCAITVGVMSYYMA 247

  Fly   222 DTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAM 286
            |...|.:||:..|.::.|:.|.....|:::||.||||..|:..:.:|      |.|:........
Zfish   248 DRKHRKAFLEARQSLEVKLNLEEQSQQQERLLLSILPKHIADEMLQD------MKKEASQKEMQQ 306

  Fly   287 ERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYY 351
            ..||.:..|.:||||:||:|.:|.|:::.:.:.|||:|::|:.|||..|.:|...|||.||||||
Zfish   307 FNTMYMYRHENVSILFADIVGFTQLSSSCSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYY 371

  Fly   352 CVAGLSDPDPDHANNCVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWG 416
            |:.||.|...|||...:::||:|:..|..||:....|::||:|||||.:..||:|:.:.|:|:|.
Zfish   372 CICGLPDYREDHAACSIMMGLAMVEAISYVREKTQTDVDMRVGVHSGTVLGGVLGQKRWQYDVWS 436

  Fly   417 LDVTIANVLESTGVPGCVHISGATLNNLDVNRFDIEDGPEEARDHPLLKKYRIRSYII------- 474
            .|||:||.:|:.|:||.||||..||..|. ..||:|.|....|.. .||:..|.:|::
Zfish   437 TDVTVANKMEAGGIPGRVHISQNTLECLH-GEFDVEPGNGGDRCE-YLKERGIETYLVVLPKGPV 499

  Fly   475 ----------------------------RQDLH---MDDEDSDEFLGDLHSISLCNMGAQPRISD 508
                                        ...:|   ...||.:|....:.:.|..|...:.|:.|
Zfish   500 GKNGINGVKLSVTSSNGNSPLLINTTECNGSVHTACTTPEDPEELDTRVVNPSFPNPRRRLRLRD 564

  Fly   509 SANQSLRALFHEELREEFRKMPVSAFSPKRLLGICRFNTGKEVPAHQNLNICLTFTDPILERAYL 573
            .|.:.:.|   :|..:|..|:...|...:        .|.:.:.......:.|.||||.||..:.
Zfish   565 LAERVIDA---QENEQELNKLLNEALLER--------ETVQALKGKYTNRLSLRFTDPELETRFS 618

  Fly   574 ----KQTDYMYKYS--IILSASVGCSLV-------YIELMDTQM------ICSSCFVLPASVATI 619
                ||:...:..|  ::|..:|..:|:       |:.|...::      |||...:.|....
Zfish   619 VEKEKQSGAAFSCSCVVLLFTAVMEALIDPWLVANYVTLAVGEVLLLILTICSLAAIFPRVFP-- 681

  Fly   620 QCILALIAWYKKYCWTRYGRNNVPHHYNGFSCFIFRIHDKILNSLPIRICIYLFLMISSFFVMCL 684
            :.:::...|...   ||:.||.    :...:.||..:.| |::.|..|......:..::...:..
Zfish   682 KRLVSFSTWIDH---TRWARNT----WAMAAIFIVTLAD-IVDMLSCRAPQTSTVESTAVPPVVT 738

  Fly   685 IVMSCQREEFEMAYIEERLFHYEQEAHICFHPWVTTNMLSLMICLTFTFAHIPIMVKTAVAILET 749
            .:..|..                       :|...:.:..|.:..|.....:..|||..:.:|.|
Zfish   739 AIRGCAE-----------------------NPKYYSFIAVLALIATTMLVQVSHMVKLTLMLLIT 780

  Fly   750 LAYLLLIFFQFDFVF---------HHSVTTNPYFKSEYAHALLICITFLIMFVKERQIEFTNKVN 805
            :|...:..:.:...|         .:.|...|   |:|..:::|.|..:..:...|.:|...:..
Zfish   781 VATGAVNIYSWSQTFDLYDLTRFKEYRVNLVP---SKYTMSVMIFIMMVSFYYFSRHVEKLARTL 842

  Fly   806 FNWRVDLRKEENAASLTNHSIIIILNNILPSHIVDVYLNSLAK-HELYFENYRMVSVMFAMLINF 869
            |.|::::.:::............::.|:||.|:...:|.|..: .|||.::|..:.||||.:.||
Zfish   843 FLWKIEVHEQKEKVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQSYDEIGVMFASIPNF 907

  Fly   870 ----------EMDLRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTS 924
                      ...:..||.|||||::||: ||...::..:.|||.:|.|||||.|:       ||
Zfish   908 SDFYTEESINNGGIECLRFLNEIISDFDS-LLDEPQFRCITKIKTIGSTYMAASGV-------TS 964

  Fly   925 TNRKESIPPTEFNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITD 989
            .|........: .||.|.|..:|...:        :..:||.|..||...|  |||      ..:
Zfish   965 DNNTNGYACMK-KEEISDRERWQHLAD--------LADFALAMKVTLMNIN--YQS------FNN 1012

  Fly   990 GTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEILQQFGITCSY 1054
            ..:.||::.|.|:||::||.:||:|||||.||:||||||||:.|:|.|.|:...||:.:|.....
Zfish  1013 FMLRIGLNKGAVLAGVIGARKPHFDIWGNTVNVASRMESTGVMGNIQVVEDCYCILKDYGFRFVR 1077

  Fly  1055 RGMTFVKGRGKIPTY-LVGIDENLNFIPQKATRFPSHQ 1091
            ||..||||:|::.|| |.|.::..:||.......| ||
Zfish  1078 RGPIFVKGKGELLTYFLKGREKQGSFINGSFVTLP-HQ 1114

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	57/271 (21%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	77/168 (46%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	88/230 (38%)
adcy3a	XP_009290286.1	AC_N	<37..304	CDD:292831	60/285 (21%)
		CYCc	273..468	CDD:214485	85/201 (42%)
		Guanylate_cyc	310..492	CDD:278633	82/183 (45%)
		CYCc	858..1075	CDD:214485	86/241 (36%)
		Guanylate_cyc	889..1096	CDD:278633	89/231 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810