Protein Alignment ACXE and adcy6a

DIOPT Version :9

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: XP_017209219.1
• Gene: adcy6a / 570652
• ZFINID: ZDB-GENE-060221-1
• Length: 1203
• Species: Danio rerio
• Alignment Length: 1159
• Identity: 313/1159 - (27%)
• Similarity: 517/1159 - (44%)
• Gaps: 242/1159 - (20%)

  Fly    31 RLESEFRLYRIRLWKSYLLTFFMLHIFVTSV----HCALLLATIERRSIIYFDVALSIGCALVLI 91
            :||..::.|..||.:|.|.....:.:.|..|    ||      |.....:.:...||:..||.|.
Zfish   162 KLERLYQRYFFRLNQSSLTMLMGVLVIVCGVMLTFHC------IHGPPDVVYASVLSVAMALFLA 220

  Fly    92 LVLSVN---FCDEFIAKHTWYMYASSIFASLTLVFADLTESIYHTYAHSWILGTFYDTYIIYMIY 153
            |::..|   |       |..||:..|......|:...:. .:......|...|.::..:.||:||
Zfish   221 LMVVCNRNGF-------HQDYMWMVSYLVIGVLIIVQVF-GVLMVAPRSASEGIWWSVFFIYIIY 277

  Fly   154 MFLPIHFISGAVLLALLVSGLYILYFVIFIAQGFAQFASALFSVGGMSVDIVHYLCLNLVGIFYR 218
            ..||:. :..|||...::|.:::|     ......|....|:.  .:|.:::.:||.|::||...
Zfish   278 TLLPVR-MRAAVLSGGVLSAIHLL-----TTWRINQDDEFLWK--QLSANVLIFLCTNIIGICTH 334

  Fly   219 VMNDTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQGIHSW 283
            ...:...|.:|.:...||:.::.|:....|:::||.|:||..:::.::.||..:    |:.:
Zfish   335 YPAEVSQRQAFQETRGYIQARLHLQRENQQQERLLLSVLPRHVAMEMKADINAK----KEDM--- 392

  Fly   284 TAMERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGD 348
              |...:.||.|.:||||:||:..:|.|.:..|.:.||..|::|:.|||..|......|||.|||
Zfish   393 --MFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLASENHCLRIKILGD 455

  Fly   349 CYYCVAGLSDPDPDHANNCVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFD 413
            |||||:||.:|..|||:.||.:|:.||..|..||::.|:::|||:|:|||.:..||:|..|.|||
Zfish   456 CYYCVSGLPEPRADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFD 520

  Fly   414 IWGLDVTIANVLESTGVPGCVHISGATLNNLDVNRFDIEDGPEEARDHPLLKKYRIRSYIIRQDL 478
            :|..|||:||.:|:.|..|.:||:.|||..|: ..:::|.|....| :..||:..|.::::   |
Zfish   521 VWSNDVTLANHMEAGGKAGRIHITKATLQYLN-GDYEVEPGFGGER-NAYLKENSIETFLV---L 580

  Fly   479 HMDDEDSDEFLGDLHSISLCNMGAQPRISDSANQSL-------RALFHEELREEFRKMPVSAFSP 536
            ....:..||         ...|....|...::|::|       |:....:..:.||:|.:...|.
Zfish   581 GCSQKRKDE---------KAMMAKMQRTRTNSNEALVPRWVPDRSFSRTKDSKVFRQMGIDETSS 636

  Fly   537 KRLLGICRFNTGKEVPAHQNLN----------------------------ICLTFTDPILERAYL 573
            |.       |.|    |.:.||                            ..|||....||:.|.
Zfish   637 KD-------NRG----AQEALNPEDEVDEFLGRAIDARSIDQLRKDHVKKFLLTFQTSSLEKKYA 690

  Fly   574 KQTDYMYKYSIILSASVGCSL--------------------VYIELMDTQMICS--SCFVL-PAS 615
            |:.|..:...:..:..|.|.:                    ::|.|.:...||:  ||..| ||:
Zfish   691 KKVDDRFGGYVACTLLVFCFISFIQIVVFPHTLVMLGIYISIFIILANILFICAIYSCVKLFPAA 755

  Fly   616 VATIQCILALIAWYKKYCWTRYGRNNV----------PHHYNGFSCFIFRIHDKILNSLPIRICI 670
            :.|:.         ||...:|.....|          ....|.|||...::.|          |:
Zfish   756 MQTVS---------KKIVQSRTNSTLVGVFTIILVFISAFVNMFSCDTQKLVD----------CV 801

  Fly   671 YLFLMISSFFVMCLIVMSCQREEFEMAYIEERLFHYEQEAHICFHP--WVTTNMLSLMICLTFTF 733
            ...|..||..|...|:.:..|.      :.:.|.........|..|  :..:.:|:|:.|  ..|
Zfish   802 AKQLNWSSEMVTPCIIHNMSRS------VADGLSICPNNTPSCPFPEYFSYSVLLTLLAC--SVF 858

  Fly   734 AHIPIMVKTAVAILETLAYLLLIFFQFDFVFHHS---VTTNPYFKSEYAH--------------- 780
            ..|..:.|.|:.:|..|.:|||:.:....:|.::   ||.|....:|...
Zfish   859 LQISSIGKLALMLLIQLTFLLLVEWPEVALFDNADLFVTANALVFNETLQWSNFNTTTEQCTFRV 923

  Fly   781 ---------ALLICITFLIMFVKERQIEFTNKVNFNWRVDLRKEENAASLTNHSIIIILNNILPS 836
                     .:::.:..|.:::..:|:|.|.:::|.|::...:|:............:|:||||.
Zfish   924 TKVSLKVMTPVILTVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPK 988

  Fly   837 HIVDVYLNSLAKH----ELYFENYRMVSVMFAMLINF-----EMD-----LRSLRVLNEIIAEFD 887
               ||..:.||:.    |||:::...|:||||.:.||     |::     :..||:||||||:||
Zfish   989 ---DVAAHFLARERRNDELYYQSCECVAVMFASISNFSEFYVELEANNEGVECLRLLNEIIADFD 1050

  Fly   888 TLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNED 952
            . ::..::|..:||||.:|.|||||.||      :.||..||.                 :|:
Zfish  1051 E-IISEEKYRQLEKIKTIGSTYMAASGL------NDSTYDKEG-----------------RSH-- 1089

  Fly   953 LDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWG 1017
                :..:..||:.:...:...||        .:..:..:.||::.|.|:||::||.:|.|||||
Zfish  1090 ----ITALADYAMHLREQMKYINE--------HSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWG 1142

  Fly  1018 NPVNMASRMESTGLPGHIHVTEETSEILQQFGITCSYRGMTFVKGRGKIPTYLV 1071
            |.||:||||:|||:|..|.||.:..::|...|.....||:..|||:|::.||.:
Zfish  1143 NTVNVASRMDSTGVPDRIQVTTDLHQVLHSKGYQLECRGVIKVKGKGEMTTYFL 1196

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	59/247 (24%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	77/168 (46%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	80/229 (35%)
adcy6a	XP_017209219.1	AC_N	<97..395	CDD:318454	61/263 (23%)
		Guanylate_cyc	397..570	CDD:306677	78/174 (45%)
		DUF1053	609..696	CDD:310728	19/97 (20%)
		Guanylate_cyc	1004..1197	CDD:306677	80/231 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910