Protein Alignment ACXE and adcy7

DIOPT Version :9

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: XP_021333246.1
• Gene: adcy7 / 568726
• ZFINID: ZDB-GENE-040713-1
• Length: 1119
• Species: Danio rerio
• Alignment Length: 1212
• Identity: 336/1212 - (27%)
• Similarity: 550/1212 - (45%)
• Gaps: 277/1212 - (22%)

  Fly    29 ELRLESEFRLYR-IRLWKSYLLTFFMLHIFVTSVHCALLLATIERRSIIYFDVALS--------- 83
            ||:.|:.:|.:. |..::.     |:|.:.::.|.||.||       :::|...|.
Zfish    13 ELKQEALYRKFSGISQYRQ-----FVLLLGLSIVTCATLL-------VLFFSFKLKAQNHGIFVG 65

  Fly    84 -IGCALVLILVLSVNFCDEFIAKHTWYMYASSIFAS-LTLVFADLTESIYHTYAHSWILGTFYDT 146
             :|.||.|.|.:.|..|.|.:::....:....::|: ||:.|..:..:........|....|: .
Zfish    66 VVGGALCLFLAVFVLVCTETLSQRWRTLLGLGVWATHLTMGFTFIFSTKSDLQIQPWDQVPFF-L 129

  Fly   147 YIIYMIYMFLPIHFISGAVLLALLVSGLYILYFVIFIAQGFAQFASALFSVGGMSVDIVHYLCLN 211
            :||..:|..||.. :|.||:|:::.|..:|:...:::.  .||..|...:...:|..:| :.|..
Zfish   130 FIIITVYTMLPFQ-MSYAVILSIISSLSHIIVLSVYLT--VAQLHSNPITFQLLSNAVV-FGCGI 190

  Fly   212 LVGIFYRVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLDSILPPQISLPLQ---------- 266
            :||||::|:.:..::.:|.|..:.:..::.|...:.|::.||.|:||..||:.::
Zfish   191 MVGIFHKVLMEKALKQTFQDTLRCLGIRMKLEIEKRQQENLLQSVLPVYISMKMKLAIMERCKCK 255

  Fly   267 -KDIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGR 330
             |:.|.|:| .....||       :.::.|.:|||||||:|.:|.|.:..:.:.||.:|::|:|:
Zfish   256 DKEEQQRMV-RDNNFHS-------LYVKRHENVSILYADIVGFTRLASDCSPKELVLMLNELFGK 312

  Fly   331 FDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVILGLSMINHIMEVRDIHGLDINMRIGV 395
            ||..|...:..|||.||||||||:||....|:||.|||.:||.|...|.:||:..|:|||||:||
Zfish   313 FDQIAKENECMRIKILGDCYYCVSGLPVSLPNHAKNCVKMGLDMCEAIKQVREATGVDINMRVGV 377

  Fly   396 HSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVHISGATLNNLDVNRFDIEDGPEEARD 460
            ||||:..||||..|.|||:|..|||:||.:||.|:||.|||:.|||.:|: ..:::|:|....||
Zfish   378 HSGNVLCGVIGLRKWQFDVWSHDVTLANHMESGGLPGRVHITEATLKHLN-KAYEVEEGNGHLRD 441

  Fly   461 HPLLKKYRIRSYIIRQDLHMDDEDSDEFLGDLHSISLCNMGAQPRISDSANQ------------- 512
             ..||:..|:::::     :|....|..|       :.....:||:||....
Zfish   442 -TYLKELNIKTFLV-----IDPRSKDSSL-------MAPSITKPRVSDGLKMRASVRMTRFLESW 493

  Fly   513 -SLRALFHEELREEF-----------------RKMPV--------SAFSPKRLLG--ICRFNTGK 549
             :::...|.:.||||                 |.:|.        |...|..|..  :..:|..|
Zfish   494 GAVKPFAHLQSREEFNTDAMVNGKGHCKDIPLRSVPTHNPDSFDESLEEPFSLPAPPLSTYNRNK 558

  Fly   550 E--------------------------VPAHQNLNICLTFTDPILERAYLKQTDYMYKYSIILSA 588
            .                          |.:.:...:.|.||...||..|.......:||.|
Zfish   559 SQKTKFDEELHDKMTTTINDLSSSKQWVKSEEISGLTLWFTKKDLEMQYRTIEMPNFKYYI---- 619

  Fly   589 SVGC-SLVYIELMDTQMICSSCFV-LPASVATIQCILALIAWYKKYCWTRYGRNNVPHHYNGFSC 651
              || :.::|.:...||:.:...: |....|.:.|.|.||.                       |
Zfish   620 --GCATFIFICIFIIQMLVTKQRIELGLGFAVLACFLLLIL-----------------------C 659

  Fly   652 FIFRIHDKILNSLPIRICIYLFLM----ISSFFVMCLIVMSCQREEFEMAYIEERLFHYEQEAHI 712
            ..|..|.:.:....::.|.:|..:    :...||..|:..........:|..|  || .::..::
Zfish   660 ICFADHIQRMFPEKLKSCTWLLALSKAVVKRPFVRILLATVATTVIVVIAMFE--LF-LKKTDNL 721

  Fly   713 C------------------FHPWVTTN-MLSLMICLTFTFAHIPIMVKTA-VAILETLAYLLLIF 757
            |                  :.|::..| :|:|:.|  ..|..:...:|.| :.|:..::|.::::
Zfish   722 CDLLQQNSSFADSARDELQYLPYLVYNCILALIAC--GVFLRVSFELKLAFLLIVSLVSYTIILY 784

  Fly   758 FQFDFVFHHSVTTNPYFKSEYAHALLIC---------------ITFLI--MFVKERQIEFTNKVN 805
            .|.:...:::...  |.......:|::|               ||..:  |.:..||.|:..:.:
Zfish   785 SQENLFSNYNCLL--YTNHSCGDSLMVCKAGLMKHPKIMSCIYITLFLFTMLLISRQNEYCCRQD 847

  Fly   806 FNWRVDLRKEENAA-----SLTNHSIIIILNNILPSHIVDVYLNSLAKHE--------------- 850
            |     |.|.:|.|     .|..:...::|.|:||:|:..:::....|:|
Zfish   848 F-----LLKNKNLADKEEVELCENLNRLLLENVLPAHVAALFVGENKKNEVGLLSAISLLNRKYK 907

  Fly   851 -LYFENYRMVSVMFAMLINF-----EMD-----LRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKI 904
             ||:::|..|.||||.:.:|     |.|     |..||:||||||:||.||...| :..|||||.
Zfish   908 DLYYKSYDCVCVMFASVPDFKEFYTECDINKEGLECLRLLNEIIADFDELLSKPK-FSGVEKIKT 971

  Fly   905 VGCTYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMR 969
            :|.|||||.||              |.||.:.|:::.|:      |..:..    |..:|:.::.
Zfish   972 IGSTYMAAAGL--------------SGPPEQSNQDRERQ------NAQIGN----MVEFAIALIG 1012

  Fly   970 TLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGH 1034
            .|...|.        .:.....:.:||:.|.|:||::||.:|.||||||.||:||||||||..|.
Zfish  1013 KLDGINR--------HSFNTFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGK 1069

  Fly  1035 IHVTEETSEILQQFGITCSYRGMTFVKGRGKIPTYLVGIDEN 1076
            |.||||||.:||..|.:|..||:..|||:|::.|:.|..|.:
Zfish  1070 IQVTEETSIVLQNLGYSCECRGLINVKGKGELKTFFVCTDSS 1111

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	61/263 (23%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	84/168 (50%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	92/229 (40%)
adcy7	XP_021333246.1	AC_N	<129..248	CDD:318454	33/122 (27%)
		Guanylate_cyc	272..455	CDD:306677	89/189 (47%)
		DUF1053	487..613	CDD:310728	19/125 (15%)
		Guanylate_cyc	909..1106	CDD:306677	92/229 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.880