Protein Alignment ACXE and adcy5

DIOPT Version :9

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: NP_001165056.1
• Gene: adcy5 / 562619
• ZFINID: ZDB-GENE-081104-470
• Length: 1186
• Species: Danio rerio
• Alignment Length: 1156
• Identity: 318/1156 - (27%)
• Similarity: 525/1156 - (45%)
• Gaps: 246/1156 - (21%)

  Fly    31 RLESEFRLYRIRLWKSYLLTFFMLHIFVTSV----HCALLLATIERRSIIYFDVALSIGCALVLI 91
            :||..::.|..||.:|.|.....:.:.|.:|    |||        ..:......|....|:|||
Zfish   155 KLERLYQRYFFRLNQSSLTMLMAVLVLVCAVMLGFHCA--------GGMCQLTFVLVFTAAIVLI 211

  Fly    92 LVLSVNFC--DEFIAKHTWYMYASSIFASLTLVFADLTESIYHTYAHSWILGTFYDTYIIYMIYM 154
            |.|.| .|  :.|...|.|.:    .:..:.||.|.....:......|...|.::..:.|::||.
Zfish   212 LTLMV-VCNRNSFHQDHMWIV----CYLLILLVLAVQVVGVLFVKPRSASEGIWWTVFFIHVIYT 271

  Fly   155 FLPIHFISGAVLLALLVSGLYILY------FVIFIAQGFAQFASALFSVGGMSVDIVHYLCLNLV 213
            .||:. :..||:..:::|.:::|.      ..:|:   :.|..|          :::.:.|.|:|
Zfish   272 LLPVR-MRAAVITGIILSAIHVLISWRLNDMDVFL---WKQLVS----------NVLIFSCSNIV 322

  Fly   214 GIFYRVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQ 278
            |:......:...|.:|.:..:.|:.::..:....|:::||.|:||..::|.::.||.     |||
Zfish   323 GVCTHYPAEGSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVALEMKADIN-----AKQ 382

  Fly   279 GIHSWTAMERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRI 343
            .    ..|...:.||.|.:||||:||:..:|.|.:..|.:.||..|::|:.|||..|......||
Zfish   383 E----DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI 443

  Fly   344 KFLGDCYYCVAGLSDPDPDHANNCVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEA 408
            |.||||||||:||.:...|||:.||.:|:.||..|..||::.|:::|||:|:|||.:..||:|..
Zfish   444 KILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLR 508

  Fly   409 KLQFDIWGLDVTIANVLESTGVPGCVHISGATLNNLDVNRFDIEDGPEEARDHPLLKKYRIRSYI 473
            |.|||:|..|||:||.:|:.|..|.:||:.||||.|: ..:|:|.|....| :..|||:.|.:|:
Zfish   509 KWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLN-GDYDVEPGSGGER-NVYLKKHNIETYL 571

  Fly   474 I------------------RQ--------DLHMDDEDSDEFLGDLHSIS--LCNMGAQPRISDSA 510
            |                  ||        ..|..|......| :.:|:|  :..||.:.....:.
Zfish   572 IVGCSQKRKEEKAMIAKMNRQRTNSVTHNSTHWTDRPFYNHL-NANSVSKEMKRMGFEDPKDKNT 635

  Fly   511 NQSLRALFHEELREEFRKMPVSAFSPKRLLGICRFNTGKEVPAHQNLNICLTFTDPILERAYLKQ 575
            .::|..   |:..:||....:.|.|..||    |....|:        ..|||.:|.||:.|.||
Zfish   636 QENLNP---EDEVDEFLGRAIDARSIDRL----RSEHVKK--------FLLTFREPDLEKKYSKQ 685

  Fly   576 TDYMYKYSIILSASVGC-SLVYIELMDTQMICSSCFVLPAS----------VATIQCILALIAWY 629
            .|..:      .|.|.| |||::.:...|:|     ::|.|          :..:..::.:.|.|
Zfish   686 VDSSF------GAYVACASLVFLFICFIQII-----IVPHSGLMVGFYVLCLVVLMVVMFISAIY 739

  Fly   630 KKYCWTRYGRNNVPHHYNGFSCFIF----------RIHDKILNSLPIRICIYLFLMISSF--FVM 682
                                |||.|          ||....|||..:.:...:.:.||:|  ...
Zfish   740 --------------------SCFGFFPIPLQTLSKRIVQSRLNSTLVGVFTIVLVFISAFINIFT 784

  Fly   683 CLI--VMSCQREEFEM---------AYIEERLFHYEQEAHICFHPWVTTN---------MLSLMI 727
            |..  :.:|..:||.:         |:.....:....:..:|.....|.|         :|||:.
Zfish   785 CSTDDLKTCLGQEFNISPSNVNACHAHFSSLNYTLWSQNRLCNSSSPTCNFPEYFSSCVLLSLLA 849

  Fly   728 CLTFTFAHIPIMVKTAVAILETLAYLLL-------IFFQFD-FVFHHSVTTN----------PYF 774
            |  ..|..:..:.|..:.:...:.|:|:       :|...| .|..:::..|          |.
Zfish   850 C--SVFLQVSSIGKLFLMLFIEILYVLIMEVPEVSLFDNVDLLVMANALAPNNGTCIVDTRVPL- 911

  Fly   775 KSEYAHALLICITFLIMFVKERQIEFTNKVNFNWRVDLRKEENAASLTNHSIIIILNNILPSHIV 839
              :....::|.:..|.:::..:|:|.|.:::|.|::...:|:............:|:||||.
Zfish   912 --KIVTPVVITVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPK--- 971

  Fly   840 DVYLNSLAKH----ELYFENYRMVSVMFAMLINF-----EMD-----LRSLRVLNEIIAEFDTLL 890
            ||..:.||:.    |||:::...|:||||.:.||     |::     :..||:||||||:||. :
Zfish   972 DVAAHFLARERRNDELYYQSCECVAVMFASISNFSEFYVELEANNEGVECLRLLNEIIADFDE-I 1035

  Fly   891 LFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLDE 955
            :...::..:||||.:|.|||||.||      :.||..|..                 :|:
Zfish  1036 ISEDQFRQLEKIKTIGSTYMAASGL------NDSTYDKAG-----------------RSH----- 1072

  Fly   956 VVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPV 1020
             :..:..||:.:|..:...||        .:..:..:.||::.|.|:||::||.:|.||||||.|
Zfish  1073 -IRALADYAMRLMDQMKYINE--------HSFNNFKMKIGLNMGPVVAGVIGARKPQYDIWGNTV 1128

  Fly  1021 NMASRMESTGLPGHIHVTEETSEILQQFGITCSYRGMTFVKGRGKIPTYLV 1071
            |:||||:|||:|..|.||.:..::|..:..|..|||:..|||:|::.||.:
Zfish  1129 NVASRMDSTGVPERIQVTTDLYQVLSSYNYTLEYRGVVKVKGKGEMMTYFL 1179

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	57/252 (23%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	78/168 (46%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	80/229 (35%)
adcy5	NP_001165056.1	AC_N	1..388	CDD:292831	61/268 (23%)
		CYCc	354..548	CDD:214485	88/203 (43%)
		Guanylate_cyc	390..574	CDD:278633	85/185 (46%)
		DUF1053	598..687	CDD:283888	26/104 (25%)
		CYCc	961..1155	CDD:214485	80/234 (34%)
		Guanylate_cyc	987..1181	CDD:278633	80/231 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910