Protein Alignment ACXE and si:dkey-206f10.1

DIOPT Version :10

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: XP_009293230.1
• Gene: si:dkey-206f10.1 / 560719
• ZFINID: ZDB-GENE-041014-154
• Length: 1187
• Species: Danio rerio
• Alignment Length: 1136
• Identity: 310/1136 - (27%)
• Similarity: 516/1136 - (45%)
• Gaps: 242/1136 - (21%)

  Fly    54 LHIFVTSVHCALLLATIERRSIIYFDVALS------IGCALVL-ILVLSVNFCDEFIAKHT--WY 109
            ||:|:      |.||....||    |:.:|      :.||:.| :|||:   |..   .|:  |.
Zfish   172 LHLFL------LYLALAPDRS----DILMSWFTGFFMACAIALCVLVLT---CKR---SHSPKWL 220

  Fly   110 MYA--SSIFASLTLVFADLTESIYHTYAHSW-ILGTFYDTYIIYMIYMFLPIHFISGAVLLALLV 171
            .||  :|..:....|...|...:...  .|| :|.|.:.||.:    :.||:.:..||   ..|.
Zfish   221 HYAGMASWLSQTAQVLGGLAYGLERD--QSWYVLFTLFATYTL----LPLPLLWAIGA---GTLT 276

  Fly   172 SGLYILYFVIFIAQGFAQFASALFSVG---GMSVDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRH 233
            |.|::.          |:....:..||   .:....:.|..:|:.|:|...:.|...|.:||:..
Zfish   277 SILHLT----------AETIRHISEVGLFRKLLAKALLYTSMNVAGLFIHYLTDRSQRQAFLETR 331

  Fly   234 QYIKEKIWLRNARLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERTM------AI 292
            :.|:.::.|.....::::|:.||||..::|.:..|:              |:|:..:      .:
Zfish   332 RCIEGRMKLETENQRQERLVLSILPRFVALEMISDM--------------TSMDDELDPQQFHKV 382

  Fly   293 QIH--PDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAG 355
            .||  .|||||:||:..:|.|:..::.:.||::|::|:||||..|..|...|||.||||||||:|
Zfish   383 YIHQYKDVSILFADIKGFTLLSMNMSAQELVRLLNELFGRFDRLAEEYDCLRIKILGDCYYCVSG 447

  Fly   356 LSDPDPDHANNCVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVT 420
            :.:|...||..||.:||:||:.:..:|.....|::||||:|:|::..||:|..|.|||:|..||.
Zfish   448 VPEPQRAHARCCVEMGLAMISTMRSLRKQQNFDMDMRIGIHTGSVLCGVLGLQKWQFDVWSWDVG 512

  Fly   421 IANVLESTGVPGCVHISGATLNNLDVNRFDIEDGPEEARDHPLLKKYRIRSYIIRQDLHMDDEDS 485
            |||:||:.|:||.:|||.|||:.|| ..|..|||....|:. .|:|:.|.:::|   .|.:|
Zfish   513 IANMLEAGGIPGRIHISRATLDCLD-GSFQTEDGRGYERNE-FLRKHNIDTFLI---CHKED--- 569

  Fly   486 DEFLGDLHSISLCNMGAQPRISDSA---NQSLRALFHEELREEFRKMPVSAFS-------PKRLL 540
                 ||:.:.    ...|:...:.   |:.:.|.|.   ...:.::|.|:..       .||:.
Zfish   570 -----DLNEME----AEHPKTRHNNRPWNKEILASFS---NGSYTQLPTSSACRSMSKEINKRIE 622

  Fly   541 GICRFNTGKEVPAHQNLNICLTFTDPILERAYLKQTDYMYKYSIILSASVGCSLVYIELMDTQMI 605
            ......:.:.:.......:.|.|.|..:|..:.:..|.|:|                    |.::
Zfish   623 HAIDLRSSERMRQEHITPVTLVFKDAHIEEKFSQVRDEMFK--------------------TNLV 667

  Fly   606 CSSCFVLPASVATIQCILALIAWYKKYCWT-------------------RYGRNNVPHHYNGFSC 651
            ||...:|     .:..:.|||...:.|.||                   .....:.|.....|.|
Zfish   668 CSFIMLL-----LLMAVQALIPVPRMYLWTVLQFCLFLLGYLLLLVMVLAEEFKHSPGVLQQFCC 727

  Fly   652 FIFRIHDKILNSLPIRICIYLFLMISSFFVMCLIVMSCQREEFEMAYIEERLFHYEQEAH----- 711
            :   ||:.  ||:  |..:.:..:..:|.:....:|.|...  ||..|..|    |.|.:
Zfish   728 W---IHEN--NSM--RNLLTITAIAMNFGMALFDMMWCNSS--EMKEISTR----ETEGYKAGQK 779

  Fly   712 ---ICFHP--WVTTNMLSLMICLTFTFAHIPIMVKTAVAILETLAYLLLIFFQFDFVF-----HH 766
               .|.:|  :|.:.::|::.|.  .|..:..::|..:.:.....|...|...|..::     |.
Zfish   780 PLTACTYPEVFVLSGVVSMVTCA--VFLRMSSLLKLTILLFVVAVYTYFIEVSFHMLYVHQQEHE 842

  Fly   767 SVTTNPYFKSEYAHALLICITFLIMFVKERQIEFTNKVNFNWRVDLRKE-ENAASLTNHSIIIIL 830
            .::.:.:.:.:....||:.:..:.:....|:.|.|.:::|.||:..::| :....|..|: ..:|
Zfish   843 HLSRSHFLRRKGVSILLMAMFMIAVLYNGRRWEATTRLDFLWRLQAQQEVQEMRDLREHN-ECLL 906

  Fly   831 NNILPSHIVDVYL-NSLAKHELYFENYRMVSVMFAMLINF----------EMDLRSLRVLNEIIA 884
            :||||:|:...:| .:....|||.::|..|.||||.:..|          ...:..|::||||||
Zfish   907 HNILPAHVARHFLERNRNDQELYSQSYDEVGVMFASIAGFNDYYEQKEIKHEGVECLKLLNEIIA 971

  Fly   885 EFDTLLLFYKEYY--TVEKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQ 947
            :||.||   :|.|  .:||||.:|..||||.||.                    .::|||.:
Zfish   972 DFDELL---EESYFLDIEKIKTIGSCYMAASGLS--------------------PDKQSRVV--- 1010

  Fly   948 QSNE--DLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQ 1010
              |:  .|.|:|.    :||.|..||.:.|:        .::.:..:.:||:.|.|:||::||::
Zfish  1011 --NDWHHLSELVL----FALAMQETLREINK--------HSMNNFQLRVGIAHGPVVAGVIGATK 1061

  Fly  1011 PHYDIWGNPVNMASRMESTGLPGHIHVTEETSEILQQFGITCSYRGMTFVKG----RGKIPTYLV 1071
            |.|||||..||:||||:|||:.|.|.|.|.|..||..:|.....||..::||    :|::.||.:
Zfish  1062 PQYDIWGMTVNLASRMDSTGVSGRIQVPEATRNILADWGFVLELRGEIYIKGVSERKGRVRTYFI 1126

  Fly  1072 GIDENL---NFIPQKATRFPSHQERSTVISL 1099
            .....|   |.|..:...  .|..|:|:.::
Zfish  1127 STKRRLVSSNGIADRGKN--GHTGRTTLAAV 1155

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AcyC	65..453	CDD:441717	133/410 (32%)
		Nucleotidyl_cyc_III	290..459	CDD:448371	80/176 (45%)
		Nucleotidyl_cyc_III	851..1071	CDD:448371	84/237 (35%)
si:dkey-206f10.1	XP_009293230.1	AC_N	<135..380	CDD:318454	59/256 (23%)
		Guanylate_cyc	382..564	CDD:425528	84/183 (46%)
		Adcy_cons_dom	<603..662	CDD:461877	9/58 (16%)
		Guanylate_cyc	928..1126	CDD:425528	84/237 (35%)