Protein Alignment ACXE and npr1a

DIOPT Version :9

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: NP_001038402.1
• Gene: npr1a / 560653
• ZFINID: ZDB-GENE-060503-539
• Length: 1067
• Species: Danio rerio
• Alignment Length: 536
• Identity: 123/536 - (22%)
• Similarity: 217/536 - (40%)
• Gaps: 102/536 - (19%)

  Fly     6 GNCQL----NYSKERMWEPGYLKAKCAELRLESEFRLYRIRLWKSYLLTFFM------LHIFVTS 60
            ||.|:    .|.|..:....|:..|..||..:..|.|..:|..::..||.|:      .:|.:.:
Zfish   554 GNFQIYAKTGYYKGNITAIKYVNKKRIELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICILT 618

  Fly    61 VHC------------ALLLATIERRSIIYFDVALSIGCALVLILV----LSVNFC---DEFIAKH 106
            .:|            .:.|..:.|.|:|. |:...:......::|    |..:.|   ..|:.|.
Zfish   619 EYCPRGSLQDLMESEGITLDWMFRYSLIN-DIVKGMAFLHNSVIVSHGNLKSSNCVVDSRFVLKI 682

  Fly   107 TWY----------------MYASSIFASLTLVFADLTESIYHTYAHSWILGTFYDTYIIYM-IYM 154
            |.|                .||..::.:..|:.||      :..|.....|..|...||.. :.:
Zfish   683 TDYGLESFHKDSNLDDVHAFYARQLWTAPELLRAD------NPPACGTQKGDVYSFGIILQELAL 741

  Fly   155 FLPIHFISGAVL-----LALLVSGLYILYFVIFIAQGFAQFASALFSVGGMSVDIVHYLCLNLVG 214
            ...:.::.|..|     :..:|.|.:.....:...|..::....|. :...|.|:......:.:.
Zfish   742 LKGVFYLEGPCLSPKEIIERVVEGRWPYLRPLLCPQSHSEEMGQLM-LRCWSEDVNERPDFSQIK 805

  Fly   215 IFYRVMNDTVVRSSFLDR-----HQY---IKEKIWLRNARLQEKQ-----LLDSILPPQISLPLQ 266
            :..| .|:....|:.||.     .||   ::|.:..|.....|::     ||..|||..::..|:
Zfish   806 VLLR-KNNCGYGSNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLK 869

  Fly   267 KDIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRF 331
            :   |.:|.|                :....|:|.::|:|.:|.|:...|...:|.:|:|||..|
Zfish   870 R---GEMVQA----------------EAFDSVTIYFSDIVGFTALSAESTPMEVVTLLNDLYTCF 915

  Fly   332 DLAAYRYKVQRIKFLGDCYYCVAGLSDPDPD-HANNCVILGLSMIN--HIMEVRDIHGLDINMRI 393
            |.....:.|.:::.:||.|..|:||...:.. ||.....:.|:::.  |...:|....|.:.:||
Zfish   916 DAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLEAVHSFRIRHRPNLQLRLRI 980

  Fly   394 GVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVHISGATLNNL-DVNRFDIE-DGPE 456
            |:|||.:.|||:|....::.::|..|..|:.:||.|....:|:|.||...| :.|.|.:| .|..
Zfish   981 GIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRGDV 1045

  Fly   457 EARDHPLLKKYRIRSY 472
            |.:.     |.|:|:|
Zfish  1046 EMKG-----KGRMRTY 1056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	54/300 (18%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	53/173 (31%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147
npr1a	NP_001038402.1	PBP1_NPR_A	48..449	CDD:107380
		ANF_receptor	66..421	CDD:279440
		PK_GC-A_B	540..814	CDD:270944	49/268 (18%)
		TyrKc	554..808	CDD:197581	47/261 (18%)
		HNOBA	<823..868	CDD:285003	10/44 (23%)
		CYCc	847..1032	CDD:214485	57/203 (28%)
		Guanylate_cyc	874..1060	CDD:278633	59/204 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900