Protein Alignment ACXE and adcy2b

DIOPT Version :10

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: XP_005170095.1
• Gene: adcy2b / 557902
• ZFINID: ZDB-GENE-060503-69
• Length: 1142
• Species: Danio rerio
• Alignment Length: 1204
• Identity: 328/1204 - (27%)
• Similarity: 544/1204 - (45%)
• Gaps: 274/1204 - (22%)

  Fly     2 PRSLG--NCQLNYSKERMWEPGYLKAKCAELRLESEFRLYRIRLWKSYLLTFFMLHIFVTSVHCA 64
            |..:|  :|.|. |.:.::|..|                   |:.:.:.|..|:|.|.:.:  |.
Zfish    64 PEDMGVSSCGLK-SPDWVYESYY-------------------RMSQQHPLIVFLLLIVMGA--CL 106

  Fly    65 LLLATI--------ERRSIIYFDVALSIGCALVLILVLSVNFCDEFIAKHTWYMYASSIFASLT- 120
            .|||..        |..:.|     :::...|.:.|.:.:..|.|.:.|....:::..|:..|.
Zfish   107 ALLAVFFASGLDMEEHMAFI-----MTVPTTLAIFLAIFILVCIESVFKKLLRLFSLLIWGCLVA 166

  Fly   121 -----LVFADLTESIYHTYAHSWILGTFYDTYIIYMIYMFLPIHFISGAVLLALLVSGLYILYFV 180
                 :.|..:        ...|...:|: .:|::::|..||.. :..||:.::|.|..:.|...
Zfish   167 MGYLFMFFGGI--------ICPWDQVSFF-LFIVFVVYTMLPFS-MRDAVIASVLTSSSHTLVLS 221

  Fly   181 IFIAQGFAQFASALFSVGGMSVDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIWLRNA 245
            |.::.......:.::.:   ..:|:.::|.|:.|.:::.:.|..::.::.|....||..|.|...
Zfish   222 ICLSNTSDHMEALVWQI---LANIIIFICGNVAGAYHKHLMDLALKQTYHDTCNCIKSPIKLEFE 283

  Fly   246 RLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERT-----MAIQIHPDVSILYADV 305
            :.|:::||.|:||..|:..::.:|..|:    :| .:::..|.|     :.:|.|.:|||||||:
Zfish   284 KHQQERLLLSLLPAHIARVMKAEIIQRL----KG-PNFSQAENTNNFHNLYVQRHTNVSILYADI 343

  Fly   306 VNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVIL 370
            |.:|.|.:..:...||.:|::|:|:||..|......|||.||||||||:||.||..|||.|||.:
Zfish   344 VGFTRLASDCSPGELVYMLNELFGKFDQIAKDNDCMRIKILGDCYYCVSGLPDPLLDHAKNCVKM 408

  Fly   371 GLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVH 435
            ||.|...|.:||:..|:|||||:||||||:..||||..|.|:|:|..|||:||.:|:.||||.||
Zfish   409 GLDMCEAIEKVREATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVH 473

  Fly   436 ISGATLNNLDVNRFDIEDGPEEARDHPLLKKYRIRSYII-------RQDL--------------- 478
            ||..||.:|: ..:.:|.|..::|| ..||::.|.:|::       |..|
Zfish   474 ISSVTLEHLN-GAYKVEQGNGQSRD-SYLKEHGIVTYLVINPKAEKRSPLLLSAIRPTMYGAKMR 536

  Fly   479 ----------------------HMDDEDSDEFLGDLHSISLCNMGAQPRISDSANQSLRALFHEE 521
                                  |.|...::..:.:...:.|.....|.|...:.:|..|  |.||
Zfish   537 ASVRMTQYLESWGAAKPFANLHHRDSMTNENGMINTRDVPLGQYNCQQRSERTKSQKKR--FEEE 599

  Fly   522 LREEFRKMPVSAFSPKRLLGICRFNTGKEVPAHQNL-NICLTFTDPILERAYLKQTDYMYKYSII 585
            |.|..            :..|...|:.|:....::: .|.|.|.:..||:.|...|...:||.:
Zfish   600 LNERI------------IRTIDGINSQKQWLKSEDIQRISLFFHNKALEKEYRATTLPAFKYYV- 651

  Fly   586 LSASVGCSLVYIELMDTQMICSSCFVLPASVATIQCILALIAWYKKYCWT----RYGRNNVPHHY 646
               :..|.:.:...:...::.....||..|......:||||..   .|:.    ::|:
Zfish   652 ---TCACLIFFCIFIVQVLVLPKTTVLEVSFGMAFLLLALILC---ICFAGHILQWGK------- 703

  Fly   647 NGFSCFIFRI--HDKILNSLP-IRICIYLFLMISSFFVMCLIVMSCQREEFEMAYI-EERL---- 703
             ..||.:.|:  ..|::.:.| ||:.:   .|.::..::.:.|       |.|.:: |:|:
Zfish   704 -AASCTMPRLPSSSKVITNKPWIRLAL---TMATTALILVMAV-------FNMFFLGEDRMVAST 757

  Fly   704 -----------------------FHYEQEAHICFHPWVTTNMLSLMICLTFTFAHIPIMVKTAVA 745
                                   |:.....:.|        :|.|:.|  ..|..|...:|..:.
Zfish   758 SLNISNSSMDGPYGQITNSSNNKFYLPYFIYSC--------ILGLISC--SVFLRINYELKMIIM 812

  Fly   746 ILETLAYLLLIFFQFDFVFHHSVTTNPYFKSEYAHALL---------------------ICITFL 789
            :...:||.::|           :.|:.....:|:.||.                     :.|.|:
Zfish   813 LGAVVAYNIII-----------LQTHASILDDYSMALYKTQQPDRPGVLKDLKTMGSISLFIFFV 866

  Fly   790 IMFVKERQIEFTNKVNFNWRVDLRKE-ENAASLTNHSIIIILNNILPSHIVDVYLNSLAKHE-LY 852
            .:.|..||.|:..:::|.||...:|| |...::.|.: .::|.|:||:|:.:.:|....|:| ||
Zfish   867 TLLVLARQNEYYCRLDFLWRNKFKKECEEIETMENLN-RVLLENVLPAHVAEHFLGRNWKNEDLY 930

  Fly   853 FENYRMVSVMFAMLINF-----EMD-----LRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGC 907
            .::|..|.||||.:.:|     |.|     |..||:||||||:||.||...| :..|||||.:|.
Zfish   931 HQSYDTVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDELLSKPK-FSGVEKIKTIGS 994

  Fly   908 TYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLA 972
            |||||.||::.             |..|:.:...|:.:.          :..|..:|..::..|
Zfish   995 TYMAATGLNVT-------------PGLEYAQYHDRQYMH----------IGTMVEFAFALVGKL- 1035

  Fly   973 KSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHV 1037
                   .:....:..|..:.:||:.|.|:||::||.:|.||||||.||:||||||||:.|.|.|
Zfish  1036 -------DVINKHSFNDFRMRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQV 1093

  Fly  1038 TEETSEILQQFGITCSYRGMTFVKGRGKIPTYLV 1071
            ||||:.|||..|..||.||:..|||:|.:.|:.|
Zfish  1094 TEETNWILQTLGYMCSCRGIINVKGKGDLRTFFV 1127

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AcyC	65..453	CDD:441717	131/406 (32%)
		Nucleotidyl_cyc_III	290..459	CDD:448371	86/168 (51%)
		Nucleotidyl_cyc_III	851..1071	CDD:448371	90/229 (39%)
adcy2b	XP_005170095.1	AcyC	97..516	CDD:441717	142/445 (32%)
		Guanylate_cyc	328..512	CDD:425528	92/185 (50%)
		Adcy_cons_dom	542..647	CDD:461877	22/118 (19%)
		Guanylate_cyc	929..1128	CDD:425528	91/231 (39%)