Protein Alignment ACXE and adcy1a

DIOPT Version :9

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: NP_001161821.1
• Gene: adcy1a / 557026
• ZFINID: ZDB-GENE-070705-302
• Length: 1114
• Species: Danio rerio
• Alignment Length: 1200
• Identity: 313/1200 - (26%)
• Similarity: 519/1200 - (43%)
• Gaps: 313/1200 - (26%)

  Fly     6 GNCQLNYSKERMWEPGYLKAKCAELRLESEFRLYRIRLWKSYLLTFFMLHIFVTSVHCALLLATI 70
            |.|:.::.             |.|  ||:.|:.|.::|.::..|....:.|...|.     ||.:
Zfish    26 GACERDFD-------------CKE--LETLFQKYNLKLEQTATLKALAILILAASA-----LALV 70

  Fly    71 ERRSIIYFDVALSIGCALVLIL----VLSVNFCDEFIAKHTWYMYASSI--FASLTLVFADL--- 126
            |         .||.|....:..    |..|.|...||..:..|:..:.:  .|.|.|:|:..
Zfish    71 E---------LLSAGSRFTVSKGSHPVHCVIFTSLFIVTNVKYLQVTQLQQIARLALLFSFTFAL 126

  Fly   127 ------------TESIYHTYAHS-------WILGTFYDTYIIYMIYMFLPIHFISGAVLLALLVS 172
                        |:..:...|.|       |.|     ..:.::.|..||:..:. |||..:||:
Zfish   127 LCCPFPLALGHGTQGTHGPDAPSTTPEQGVWQL-----MLVTFVAYSLLPVRTLL-AVLFGVLVA 185

  Fly   173 GLYILYFVIFIAQGFAQ--------FASALFSVGGMSVDIVHYLCLNLVGIFYRVMNDTVVRSSF 229
            .   .:|::......|:        .|:|:..||           :||.|:|.||..:...|.:|
Zfish   186 A---SHFIVTATSVTARRPRVWTPLVANAVLLVG-----------VNLSGVFVRVRTERAQRKAF 236

  Fly   230 LDRHQYIKEKIWLRNARLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAIQI 294
            |.....|::::.|.:...::::||.|:||..:::.:::|.   :...::..|.       :.||.
Zfish   237 LQARNCIQQRLQLEDENEKQERLLMSLLPRNVAMEMKEDF---LKPPERIFHK-------IYIQR 291

  Fly   295 HPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDP 359
            |.:||||:||:|.:|.|.:..|.:.|||:|::|:|:||..|.....:|||.||||||||:||:.|
Zfish   292 HDNVSILFADIVGFTSLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQP 356

  Fly   360 DPDHANNCVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANV 424
            ..|||:.||.:||.||:.|..|.:...:|:|||:|:|:|.:..||:|..|.|:|:|..|||:||:
Zfish   357 KADHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANM 421

  Fly   425 LESTGVPGCVHISGATLNNLDVNRFDIEDGPEEARDHPLLKKYRIRS------------------ 471
            :|:.|:||.|||:.|||..|: ..:::|.|....| |..|.|:.|.:
Zfish   422 MEAGGLPGKVHITKATLECLN-GDYEVEPGFGHER-HAFLSKHAIETFFIVPSHRRKIFPGLILS 484

  Fly   472 --------------YIIRQDLHMDDEDSDEFLGDLHSISLCNMGAQPRISDSANQSLRALFHEEL 522
                          |::.|.:|.......|.  ...::..|....:.|...:|::.||.
Zfish   485 DIKPAKRMEFKTVCYLLVQLMHCRKMFKAEI--PFSNVMTCEDDDKRRALRTASEKLRN------ 541

  Fly   523 REEFRKMPVSAFSPKRLLGICRFNTGKEVPAHQ------NLN-ICLTFTDPILERAYLKQTDYMY 580
            |..|....|......|   :.|: .|:.:.|.|      :|| |.||:.....|:.||:..|..:
Zfish   542 RTSFSAGMVQNSPGTR---VNRY-IGRLIEARQTESEMADLNYITLTYRSREREQRYLQVYDDAF 602

  Fly   581 KYSIILS-----------------------ASVGC------SLVYIELMDTQMICS-SCFVLPAS 615
            ..::::|                       ..|.|      |::|:.:  |.:.|| .|..|  .
Zfish   603 ISAVVISLVLTSFFAVVYFLIIPQGLLVVILLVLCLCFHMASVMYLHV--THVQCSPDCLTL--Q 663

  Fly   616 VATIQCILALIAWYK--KYC------WTRYGRNNVPH----HYNGFSCFIFRIHDKILNSLPIRI 668
            :.|:.|...::..|.  :.|      |:..|.:::..    ..||             ..:..|:
Zfish   664 IRTVLCGFLVLLMYSVTQGCVVTCVPWSLEGNSSISMVTVVTVNG-------------TGVGYRV 715

  Fly   669 CIYLFLMISSFFVMCLIVMSCQREEFEMA-YIEERLFHYEQEAHICFHPWVTTNMLSLMICLTFT 732
            |.|          ...:.:||......:| |:.                  .:::..:::.|...
Zfish   716 CKY----------TPYVFLSCVMASLSVALYLR------------------VSSLPKILLLLLLN 752

  Fly   733 FAHIPIMVKTAVAILETLAYLLLIFFQFDFVFHHSVTTNPYFKSEYAHALLICITFLIMFVKERQ 797
            ..|        ..::||..|...:...|   ||    |:.|   :...|:|:....|::..  ||
Zfish   753 ILH--------TVVMETSGYRKAVGGGF---FH----THGY---DPVLAMLLFSGALVLHC--RQ 797

  Fly   798 IEFTNKVNFNWRVDLRKEEN---AASLTNHSIIIILNNILPSHIVDVYLNSLAKH-ELYFENYRM 858
            ::...::::.|.....:|.:   ...|.|..|:.   |:||:|:...:|.|..:: :||:::|..
Zfish   798 LDLKLRLDYLWATQAEEERDDMERVKLDNKRILF---NLLPAHVAQHFLLSNPRNMDLYYQSYSQ 859

  Fly   859 VSVMFAMLINF----------EMDLRSLRVLNEIIAEFDTLLLFYKE-YYTVEKIKIVGCTYMAA 912
            |.|:||.:.||          .|.:..||:||||||:||.|:  .|| |..:||||.:|.|||||
Zfish   860 VGVLFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDALM--DKECYRDIEKIKTIGSTYMAA 922

  Fly   913 CGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEA 977
            .||                .|||.::.:          :.:...:..:..||::|...|...|
Zfish   923 VGL----------------VPTEGSKVK----------KSISAHLCTVADYAIEMFDVLDAIN-- 959

  Fly   978 YQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETS 1042
            |||      ..|..:.:||:.|.|:||::||.:|.||||||.||:||||:|||:.|.|.|||:..
Zfish   960 YQS------YNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGKIQVTEDVF 1018

  Fly  1043 EILQ-QFGITCSYRGMTFVKGRGKIPTYLV 1071
            .:|. .:...|  ||...|||:|::.||.:
Zfish  1019 RLLSGYYDFNC--RGQVSVKGKGQMLTYFL 1046

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	60/276 (22%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	79/168 (47%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	87/231 (38%)
adcy1a	NP_001161821.1	AC_N	<154..285	CDD:292831	33/153 (22%)
		CYCc	251..446	CDD:214485	84/205 (41%)
		Guanylate_cyc	287..469	CDD:278633	84/183 (46%)
		DUF1053	513..601	CDD:283888	23/99 (23%)
		CYCc	819..1029	CDD:214485	87/248 (35%)
		Guanylate_cyc	852..1048	CDD:278633	87/232 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810