DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXE and npr1b

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	XP_009290669.2	Gene:	npr1b / 555911	ZFINID:	ZDB-GENE-100805-4	Length:	1070	Species:	Danio rerio

Alignment Length:	275	Identity:	76/275 - (27%)
Similarity:	132/275 - (48%)	Gaps:	42/275 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 RSSFLDR-----HQY---IKEKIWLR-NARLQEKQ----LLDSILPPQISLPLQKDIQGRIVMAK 277
            ||:.||.     .||   ::|.:..| .|.|:||:    ||..|||..::..|           |
Zfish   820 RSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQL-----------K 873

  Fly   278 QGIHSWTAMERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQR 342
            :|        .|:..:....|:|.::|:|.:|.|:...|...:|.:|:|||..||.....:.|.:
Zfish   874 RG--------ETVQAEAFDSVTIYFSDIVGFTSLSAESTPLQVVTLLNDLYTCFDAIIDNFDVYK 930

  Fly   343 IKFLGDCYYCVAGLSDPDPD-HANNCVILGLSMINHIMEVRDIHGLD--INMRIGVHSGNLFAGV 404
            ::.:||.|..|:||...:.. |......:.|:::..:...:..|..|  :.:|||:|||.:.|||
Zfish   931 VETIGDAYMVVSGLPVRNGKLHGREIARMSLALLEAVKTFKIRHRPDEQLKLRIGIHSGPVCAGV 995

  Fly   405 IGEAKLQFDIWGLDVTIANVLESTGVPGCVHISGATLNNL-DVNRFDIE-DGPEEARDHPLLKKY 467
            :|....::.::|..|..::.:||.|.|..:|:|.||...| :.|.|.:| .|..|.:.     |.
Zfish   996 VGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSATRAVLQEFNCFQLELRGDVEMKG-----KG 1055

  Fly   468 RIRSYIIRQDLHMDD 482
            ::|:|.:..::...|
Zfish  1056 KMRTYWLLGEVKAGD 1070

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	18/58 (31%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	51/173 (29%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147
npr1b	XP_009290669.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900