DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXE and gucy1a1

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_001296458.1	Gene:	gucy1a1 / 550420	ZFINID:	ZDB-GENE-050417-230	Length:	679	Species:	Danio rerio

Alignment Length:	293	Identity:	81/293 - (27%)
Similarity:	135/293 - (46%)	Gaps:	47/293 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 VIFIAQGFAQFASALFSVGGMSVDIVHYLC---LNLVGI-FYRVMNDTVVRSSFLDRHQYIKEKI 240
            :||:::     .|||..:|...||.:..|.   |.|..| .:..:.|.|:..........:|:::
Zfish   374 MIFMSE-----MSALLFLGSPCVDKLEELTGRGLYLSDIPIHNALRDVVLVGEQTKAQDGLKKRL 433

  Fly   241 WLRNARLQEK------------QLLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAIQ 293
            ....|.|::.            :||.:|.|..::   |:..||..|.||:..|
Zfish   434 GKAKAALEQAHQALEEEKRRTVELLFTIFPGNVA---QRLWQGLPVQAKKFDH------------ 483

  Fly   294 IHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSD 358
                |::|::|:|.:|.:.:..|...:|.:|.:||.|||.......|.:::.:||.|....||..
Zfish   484 ----VTVLFSDIVGFTAICSRCTPMQVVNMLSELYTRFDHHCGELDVYKVETIGDAYCVAGGLHK 544

  Fly   359 PDPDHANNCVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIAN 423
            ..|.||....::.|.|:....||....|..|.||||:|||::.|||:|....::.::|.:||:||
Zfish   545 ESPTHAVQIALMALKMMELSDEVTTPMGEVIRMRIGIHSGSVLAGVVGVKMPRYCLFGNNVTLAN 609

  Fly   424 VLESTGVPGCVHISGATLNNLDVNRFDIEDGPE 456
            ..||..:|..:::|..|...|       :|.||
Zfish   610 KFESCSLPRKINVSPTTYRLL-------KDCPE 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	23/107 (21%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	53/167 (32%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147
gucy1a1	NP_001296458.1	HNOBA	279..470	CDD:285003	22/103 (21%)
		CYCc	449..635	CDD:214485	62/211 (29%)
		Guanylate_cyc	476..647	CDD:278633	57/183 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810