DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXE and ACXA

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster

Alignment Length:	1111	Identity:	533/1111 - (47%)
Similarity:	740/1111 - (66%)	Gaps:	50/1111 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 CQLNYSKERMWEPGYLKAKCAELRLESEFRLYRIRLWKSYLLTFFMLHIFVTSVHCALLLATIER 72
            |.|.|:.||:||..||||:|.||.||.|:..|:|||..|.|..|..:.|.:......::.:..|.
  Fly    18 CNLEYTNERLWEQSYLKARCKELHLEEEYMKYKIRLMISSLTVFVPMLILLIVALQVIIWSFTEY 82

  Fly    73 RSIIYFDVALSIGCALVLILVLSVNFCDEFIAKHTWYMYASSIFASLTLVFADLTESIYHTYAHS 137
            ...||.:....:|..:::..:||:||.::|:.:|.|.|..:|..::..:|..|:..:.|:.|..:
  Fly    83 TKYIYINAIFDLGSLILVTGLLSINFFEDFVIRHRWVMTFTSTLSAYVVVLGDIAFNTYYYYKSN 147

  Fly   138 WILGTFYDTYIIYMIYMFLPIHFISGAVLLALLVSGLYILYFVIFIAQGFAQFASALFSVGGMSV 202
            |.|.|.||.:::.||||||||.....|.|||:.||..|::||:.|:|......|..:..:..:|:
  Fly   148 WPLNTLYDVFVLCMIYMFLPIPSSKAAALLAISVSLTYVIYFIHFMAFNEHNVAKYVHGLDIVSI 212

  Fly   203 DIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLDSILPPQISLPLQK 267
            |..|||..|::|||:|:||||:||||||||:|:|.|:||||.||.||..||||||||||:.|:||
  Fly   213 DFFHYLGFNMMGIFFRIMNDTMVRSSFLDRYQFITEEIWLRQARRQESLLLDSILPPQIAKPIQK 277

  Fly   268 DIQGRIVMAKQGIH----SWTAMERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLY 328
            .|:.:|:......:    |.|| |..|:||||.||||||||:||||.||||||||.|||||||||
  Fly   278 SIKEKIIQPDNDFYHLGTSRTA-ENFMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLY 341

  Fly   329 GRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVILGLSMINHIMEVRDIHGLDINMRI 393
            .||||||..:||||||||||||||||||.:.|||||...|.||:|||.:|.||.....|:|.|||
  Fly   342 ARFDLAALSFKVQRIKFLGDCYYCVAGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRI 406

  Fly   394 GVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVHISGATLNNLDVNRFDIEDGPEEA 458
            |||||.|||||||:||||:||||.||.||:.||:||.||.||:||.||::|:...::|..|.|.|
  Fly   407 GVHSGTLFAGVIGKAKLQYDIWGADVNIASRLEATGSPGYVHVSGRTLSSLNAEEYNIYPGTESA 471

  Fly   459 RDHPLLKKYRIRSYIIRQDLHMDDEDSDEFLGDLHSISLCNMGAQPRISDSANQSLRA-LFHEEL 522
            :..|:|:|:.:.:|::.....:|.:.:...:..:.::.|..:|     |:..:|.|:. |...|:
  Fly   472 QKDPVLQKHPMSTYLLTAIPSLDSDKTISIVEGVPNLDLQTVG-----SNRKSQILKPNLLSHEM 531

  Fly   523 REEFRKMPVSAFS-----PKRLLGICRFNTGKEVPAHQNLNI-CLTFTDPILERAYLKQTDYMYK 581
            |||||||||..|.     .:|...:      |.....::|.| |:.|.|..:|..||.|.||::|
  Fly   532 REEFRKMPVGGFKFQFPWSRRERNL------KNEKVERDLGIFCVAFKDKSVEWNYLHQPDYIFK 590

  Fly   582 YSIILSASVGCSLVYIELMDTQMICSSCFVLPASVATIQCILALIAWYKKYCWTRYGRNNVPHH- 645
            ||:.|...:||.|:||:.::...|..:..|:......:...|..|.||||.||...|:|.  |.
  Fly   591 YSVALGWGIGCCLIYIQSVNNSDIFYTGVVINIIAFFVLTFLLFICWYKKVCWWHSGQNE--HRS 653

  Fly   646 YNGFSCFIFRIHDKILNSLPIRICIYLFLMISSFFVMCLIVMSCQREEFEMAYIEERLFHYEQEA 710
            |...||.||.:.:||.:|..:|:.:|:.:::..:.|:.||:|||:::::|:..||.:|::|:.:.
  Fly   654 YGKLSCAIFHLFEKIQHSFVLRLTVYMMIILCYYMVISLILMSCEKDQYELDIIESKLYNYDMDP 718

  Fly   711 HICFHPWVTTNMLSLMICLTFTFAHIPIMVKTAVAILETLAYLLLIFFQFDFVFHHSVTTNPYFK 775
            ..|||||..|||::|::.:::|||.||..:||.:...|.:.::|::.||:.|:|.|||||:||.|
  Fly   719 FTCFHPWAYTNMMALILGMSYTFARIPFALKTFIGCAEAVVFVLVVCFQYAFIFEHSVTTSPYLK 783

  Fly   776 SEYAHALLICITFLIMFVKERQIEFTNKVNFNWRVDLRKEENAASLTNHSIIIILNNILPSHIVD 840
            :|.||:..:|:..:.|:.||||.||..|:|:...:||:.::.:|.:||.||||:||||||||:|:
  Fly   784 AEIAHSCRVCMMLITMYAKERQSEFNTKMNYKLNLDLQNKQKSADVTNQSIIILLNNILPSHVVE 848

  Fly   841 VYLNSLAKHELYFENYRMVSVMFAMLINFEMDLRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIV 905
            |||:|:||||||:|||||||||||||.||:|||.||||||:||..||.||..||:||.|||||:|
  Fly   849 VYLSSIAKHELYYENYRMVSVMFAMLTNFQMDLPSLRVLNDIITAFDRLLSAYKQYYVVEKIKVV 913

  Fly   906 GCTYMAACGLDL----------NFAGSTSTNRKESIPPTEFNEEQSR-RILFQQSNEDLDEVVFV 959
            |||||||||||.          || ||||.:       :|..:.:|| ....::.|.  |||.|:
  Fly   914 GCTYMAACGLDFSLIENLDSNSNF-GSTSLS-------SELEQVRSRLESSIKEKNH--DEVAFI 968

  Fly   960 MTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMAS 1024
            |.::|||:||.|:..|:||.....||.::.|.|.||||:|::|||:|||||||||||||||||||
  Fly   969 MATFALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPVNMAS 1033

  Fly  1025 RMESTGLPGHIHVTEETSEILQQFGITCSYRGMTFVKGRGKIPTYLVGIDENLNFIPQKATRF-- 1087
            |||||||.|||.||:||::.|::|.:.|.|||:|||||||:||||.||||::|.|:.:|..|.
  Fly  1034 RMESTGLSGHIQVTKETAQTLEEFDVMCYYRGLTFVKGRGEIPTYFVGIDKDLKFMSKKIDRLSE 1098

  Fly  1088 -PSHQE 1092
             ||:.:
  Fly  1099 NPSNPD 1104

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	100/240 (42%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	117/168 (70%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	139/230 (60%)
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	101/248 (41%)
		CYCc	262..464	CDD:214485	133/202 (66%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	120/182 (66%)
		CYCc	831..1055	CDD:214485	144/233 (62%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	139/230 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449937
Domainoid	1	1.000	187	1.000	Domainoid score	I6943
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG27505
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	1	1.000	-	-		FOG0007605
OrthoInspector	1	1.000	-	-		otm48748
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.860