DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXE and Phlpp2

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_001102601.2	Gene:	Phlpp2 / 498949	RGDID:	1562857	Length:	1359	Species:	Rattus norvegicus

Alignment Length:	1016	Identity:	198/1016 - (19%)
Similarity:	335/1016 - (32%)	Gaps:	312/1016 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 IFYRVMNDTVVRSSFLDR-----HQYIKEKIWLRNARLQEKQLLDSILPPQISL--------PLQ 266
            ::.::..|.|.|....:|     :.|:....:....|:||:     ...|.:|.        |.|
  Rat   121 LYLQLHGDLVRRLEPTERPLQIVYDYLSRLGFEDPVRIQEE-----ATNPDLSCMIRFYGEKPCQ 180

  Fly   267 KDIQGRIVMA--------KQGIHSWTAMER------------------TMAIQIHPDVSILYADV 305
            .|...||:::        |..:|.|.  ||                  |..:.|.|.|.....:|
  Rat   181 MDHLDRILLSGIYNVRKGKTQLHKWA--ERLVVLCGTCLIVSSVKDCQTGKMHILPLVGGKIEEV 243

  Fly   306 VNYTH-----------LTTTLTVEMLV----------KVLHDLYGRFDLAAYR--------YKVQ 341
            ....|           .|..::.|.|.          ||:.......||:.|.        :..|
  Rat   244 KRRQHSLAFSSAGAQAQTYHVSFETLAEYQRWQRQASKVVSQRISTVDLSCYSLEEVPEHLFYSQ 308

  Fly   342 RIKFLG--------------DCYYCVAGLSDPDPDHANN--------CVILGLSMINHIMEVRDI 384
            .|.:|.              |..|..:.|...:..| |.        |.|..|:.:|  :.....
  Rat   309 DITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSH-NKLGLFPVLLCEISTLTELN--LSCNGF 370

  Fly   385 HGLD------INMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIAN------VLESTGVPGCVHIS 437
            |.|.      :|::.....||:...:..|......:..|.::..|      |||...:...|.::
  Rat   371 HDLPSQIGNLLNLQTLCLDGNVLTALPDELGNLQQLTSLGISFNNFSQIPEVLEKLTMLDKVVMA 435

  Fly   438 GATLNNLDVNRFDIEDGPEEARDHPLLKKYRIRSYII------RQDLHMDDEDSDEFLGDLHSIS 496
            |   |.|::....:.......: |..|:...:::.||      :...|||..|:.  |.||...|
  Rat   436 G---NRLEILNLGVLTRMNHVK-HVDLRMNHLKTVIIENLEGNKHITHMDLRDNQ--LTDLDLSS 494

  Fly   497 LCNMGAQPRISDSANQSLRALFHEELREEFRKMPVSAFSPKRLLGICRFNTGK-------EVPA- 553
            ||              ||..|..|  |.:.|::.:|.||.:.|..    |..|       .||:
  Rat   495 LC--------------SLEQLHCE--RNQLRELTLSGFSLRNLYA----NWNKLTAVNVYPVPSL 539

  Fly   554 ------HQNLNICLTFTDPILERAYLKQTDYMYKYSIILSASVGCSLVYIELMDTQMICSSCFVL 612
                  .:||..|:  .|...|...|:..|..|.....:...:..||...:||...   :...||
  Rat   540 LTSLELSRNLLECI--PDWACEAKKLEILDISYNLLTEVPMRILSSLSLRKLMVGH---NHIHVL 599

  Fly   613 PASVATIQCILALIAWYKKYCWTRYGRNNVPHHYNGFSCFIFRIHDKILN-SLPIRICIYLFLMI 676
            ||.|..|.  |.::              :|.|:      .:.|:.|.:.: :|.:|   ||....
  Rat   600 PALVEHIP--LEVL--------------DVQHN------TLSRLPDTLFSKALNLR---YLNASA 639

  Fly   677 SSFFVMCLIVMSCQREE----FEMAYIEERLFHYEQEAHICFHPWVTTNMLSLMICLTFTFAHIP 737
            :|   :..:..:|..||    .::.|:...|...:....:..||.:....|:.....||..:.:.
  Rat   640 NS---LESLPSACAGEESLSVLQLLYLTNNLLTDQCIPVLVGHPHLRVLHLANNQLQTFPASKLN 701

  Fly   738 IM---------------VKTAVAILETLAYLLLIFFQFDFVFHHSVTTNPYFKSEYAHALLICIT 787
            .:               :.|.:|..:.|..|:                        |||..|.|.
  Rat   702 KLEQLEELNLSGNKLKAIPTTIANCKRLHTLV------------------------AHANNISIF 742

  Fly   788 FLIMFVKERQIEFTNKVNFNWRVDLRKEENAASLTNHSIIIILNNILPSHIVDVYL----NSLAK 848
            ..|:.:.  ||:|         |||    :...||.    |::...||:.:.|:.|    |.:.:
  Rat   743 PEILQLP--QIQF---------VDL----SCNDLTE----ILIPETLPATLQDLDLTGNTNLVLE 788

  Fly   849 HELYFENYRMVSVMFAMLINFEMDLRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVG-----CT 908
            |:        ...||:.:...::|.:.|...:..:.         ..:::....::.|     |
  Rat   789 HK--------TLDMFSHITTLKIDQKPLPTTDSTVT---------STFWSHGLAEMAGQRNKLC- 835

  Fly   909 YMAACGLDLNFA-------GSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLDEVVFVMTSYALD 966
             ::|..:| |||       |....:|.|.:|  ...:.....:|.::......:.||:..:: |.
  Rat   836 -VSALAMD-NFAEGVGAVYGMFDGDRNEELP--RLLQCTMADVLLEEVQHSTSDTVFMANTF-LV 895

  Fly   967 MMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGL 1031
            ..|.|..:.:...|.|....|...| |...||..:....||..|......|.||.: |::.|..
  Rat   896 SHRKLGMAGQKLGSSALLCYIRPDT-ADPTSSFSLTVANVGTCQAVLCRGGKPVPL-SKVFSLE- 957

  Fly  1032 PGHIHVTEETSEILQQ----------FGITCSYR--GMTFV 1060
                |..||...:..|          .|:||..|  |.|::
  Rat   958 ----HDPEEAQRVKDQKAIITEDNKVNGVTCCTRMLGCTYL 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	13/69 (19%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	40/231 (17%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	46/234 (20%)
Phlpp2	NP_001102601.2	RA_PHLPP2	66..178	CDD:340761	10/61 (16%)
		PH_PHLPP-like	185..279	CDD:270131	16/95 (17%)
		PLN00113	284..>762	CDD:215061	112/578 (19%)
		leucine-rich repeat	289..309	CDD:275380	3/19 (16%)
		leucine-rich repeat	310..336	CDD:275380	4/25 (16%)
		leucine-rich repeat	337..359	CDD:275380	5/22 (23%)
		leucine-rich repeat	360..382	CDD:275380	4/23 (17%)
		leucine-rich repeat	383..405	CDD:275380	3/21 (14%)
		leucine-rich repeat	406..428	CDD:275380	5/21 (24%)
		leucine-rich repeat	429..452	CDD:275380	4/25 (16%)
		leucine-rich repeat	453..476	CDD:275380	4/23 (17%)
		leucine-rich repeat	477..497	CDD:275380	10/35 (29%)
		leucine-rich repeat	498..517	CDD:275380	6/20 (30%)
		leucine-rich repeat	518..539	CDD:275380	5/24 (21%)
		leucine-rich repeat	540..562	CDD:275380	5/23 (22%)
		leucine-rich repeat	563..584	CDD:275380	3/20 (15%)
		leucine-rich repeat	586..607	CDD:275380	7/23 (30%)
		leucine-rich repeat	608..631	CDD:275380	5/42 (12%)
		leucine-rich repeat	632..681	CDD:275380	10/54 (19%)
		leucine-rich repeat	682..705	CDD:275380	3/22 (14%)
		leucine-rich repeat	706..728	CDD:275380	2/21 (10%)
		leucine-rich repeat	751..772	CDD:275380	9/37 (24%)
		PP2Cc	820..1069	CDD:238083	42/188 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900