DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXE and NPR2

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	XP_024303324.1	Gene:	NPR2 / 4882	HGNCID:	7944	Length:	1103	Species:	Homo sapiens

Alignment Length:	277	Identity:	74/277 - (26%)
Similarity:	130/277 - (46%)	Gaps:	47/277 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 FYRVMN----DTVVRSSFLDRHQY-------IKEKIWLRNARLQEKQ----LLDSILPPQISLPL 265
            |.|..|    .:::.:..|...||       ::|:   ..|.|:||:    ||..|||..::..|
Human   841 FIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEER---TQAYLEEKRKAEALLYQILPHSVAEQL 902

  Fly   266 QKDIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGR 330
                       |:|        .|:..:....|:|.::|:|.:|.|:...|...:|.:|:|||..
Human   903 -----------KRG--------ETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTC 948

  Fly   331 FDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPD-HANNCVILGLSMINHIMEVRDIHGL--DINMR 392
            ||.....:.|.:::.:||.|..|:||...:.. ||.....:.|::::.:...|..|..  .:.:|
Human   949 FDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLR 1013

  Fly   393 IGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVHISGATLNNLD-VNRFDIE-DGP 455
            ||||:|.:.|||:|....::.::|..|..|:.:||.|....:|:|..|.:.|| :..|.:| .|.
Human  1014 IGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGD 1078

  Fly   456 EEARDHPLLKKYRIRSY 472
            .|.:.     |.::|:|
Human  1079 VEMKG-----KGKMRTY 1090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	17/70 (24%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	51/173 (29%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147
NPR2	XP_024303324.1	Periplasmic_Binding_Protein_Type_1	26..421	CDD:324556
		PK_GC-A_B	521..848	CDD:270944	3/6 (50%)
		HNOBA	<857..902	CDD:311573	13/47 (28%)
		CYCc	881..1065	CDD:214485	56/202 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900