DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXE and Gycalpha99B

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster

Alignment Length:	374	Identity:	91/374 - (24%)
Similarity:	149/374 - (39%)	Gaps:	84/374 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 LTLVFADLTESIYHTYAHSWILGTFYDTYIIYMIYMFLPIHFISGAV---LLALLVSGLYILYFV 180
            ||:.|.|:...                ||..::|.:..|    .|||   .:.|.:.|..:
  Fly   316 LTMKFRDIVRR----------------TYTPFLIGLNNP----PGAVDFPAIGLEIKGQMV---- 356

  Fly   181 IFIAQGFAQFASALFSVGGMSVDIVHYLCLNLVGIFYR-------------VMNDTVVRSSFLDR 232
                  ....:::|..:|...:|.:..|..|  |:|..             |......:.....|
  Fly   357 ------HCPESNSLLFIGSPFLDGLDGLTCN--GLFISDIPLHDATREVILVGEQARAQDGLRRR 413

  Fly   233 HQYIKEKIWLRNA-----RLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAI 292
            ...||..|...|:     |.:...||..|.|.:|:..|                 |  :..::..
  Fly   414 MDKIKNSIEEANSAVTKERKKNVSLLHLIFPAEIAEKL-----------------W--LGSSIDA 459

  Fly   293 QIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLS 357
            :.:|||:||::|:|.:|.:.:..|..|::.:|..||..||.....:.|.:::.:||.|...:||.
  Fly   460 KTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVASGLH 524

  Fly   358 DPDPDHANNCVILGLSMIN----HIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLD 418
            ......|:....:.|.||:    ||..    .|..|.||||:|:|.:.|||:|....::.::|..
  Fly   525 RASIYDAHKVAWMALKMIDACSKHITH----DGEQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHS 585

  Fly   419 VTIANVLESTGVPGCVHISGATLNNLDVNR-FDIEDGPEEARDHPLLKK 466
            |||||..||......:::|..|.:.|..:. |:.|..|   ||...|.|
  Fly   586 VTIANKFESGSEALKINVSPTTKDWLTKHEGFEFELQP---RDPSFLPK 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	33/173 (19%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	53/173 (31%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002
		HNOBA	259..451	CDD:285003	32/166 (19%)
		CYCc	430..619	CDD:214485	59/211 (28%)
		Guanylate_cyc	457..647	CDD:278633	57/182 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453983
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740