DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXE and CG32301

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_728724.2	Gene:	CG32301 / 38285	FlyBaseID:	FBgn0052301	Length:	1111	Species:	Drosophila melanogaster

Alignment Length:	1158	Identity:	377/1158 - (32%)
Similarity:	576/1158 - (49%)	Gaps:	130/1158 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RSLGNCQLNYSKERMWEPGY----LKAKCAELRLESEFRLYRIRLWKSYLLTFFMLHIFVTSVHC 63
            |||||.           |||    |:.||.|||||..:..                       ||
  Fly    13 RSLGNM-----------PGYEWKLLRYKCRELRLEGVYHR-----------------------HC 43

  Fly    64 ALLLATIERRSIIYFDVALSIGCALVLILVLSVNFC--------------------DEFIAKHTW 108
            .|:...:..:.||..::.:.|...|:..:|.:::|.                    :..:.::..
  Fly    44 HLVSVALVTQLIIVIEILMLIHVILLFSVVKNIDFLTVLPYFAVMLLTPSILMPSREPNVEQYES 108

  Fly   109 YMYASSIFASLTLVFADLTESIYHTYAHSWILGTFYDTYIIYMIYMFLPIHFISG--AVLLALLV 171
            .....|...:|.|...||...|  .|...:.|...||..:|.:||:..||.|:..  |..|.|.|
  Fly   109 IAILVSCLMALLLTAMDLILPI--CYFRPFSLVPSYDHVVIVLIYLMFPIAFVKNGRAYFLGLAV 171

  Fly   172 SGLYILYFVIFIAQGFAQFASALFSVGGMSVDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYI 236
            |..|..|..:.      ...|.|..|..::....:...||::.:|.....:..:||..|.|:|.:
  Fly   172 SLFYFGYMALI------DKISTLDKVWELTAYGAYLFFLNMLCMFLSRFQEYNMRSGILSRYQVV 230

  Fly   237 KEKIWLRNARLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSIL 301
            .:.:..:.|..:||.|||||:|..::..||..|...|......:..:| ..|.:.::.||:||||
  Fly   231 YQNLVFQMAMKEEKALLDSIIPVTLARSLQDAIASHIEEDPSNLMPFT-KTRHLFMEPHPEVSIL 294

  Fly   302 YADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANN 366
            .||:|::|.||||:.|..||.:||:|:..|||||...:..|||||||.|.||.|:....|.|||.
  Fly   295 EADMVDFTGLTTTMEVSDLVAILHELFVSFDLAANHNRATRIKFLGDSYTCVTGIPSYFPTHANA 359

  Fly   367 CVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVP 431
            ||...|.||....||.......|::|||||||.:.||:||..|.|||||..||.|.|.|||:|:|
  Fly   360 CVNQALDMIEISREVSKRRNKKIDLRIGVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLP 424

  Fly   432 GCVHISGATLNNLDVNRFDIEDGPEEARDHPLLKKYRIRSYIIRQDLHMDDEDSDEFLGDLHSIS 496
            |.||||..||..|| |.:..|:|.:.|:..|||::..:.:|:||..| .:.||:|:...|..|::
  Fly   425 GMVHISSRTLGLLD-NHYVYEEGTDTAKLDPLLQRSNLSTYLIRSRL-PNFEDTDDLEDDNFSLN 487

  Fly   497 LCNMGAQPRISDSANQSLRALFHEELRE---EFRKMPVSAFSP----KRLLGICRFNTGKEVPAH 554
                  ..|.|.|.:|....:..:..|:   |...|||:....    :.:..|.:.:..:|...|
  Fly   488 ------DYRFSFSFSQDYEDIQVKAQRDMILEVEHMPVNRVQTCKIRRPMHRIAKEDINEEYRFH 546

  Fly   555 -QNLNICLTFTDPILERAYLKQTDYMYKYSIILSASVGCSLVYIEL------MDTQMICS--SCF 610
             ::..:..||....:|.::.|..|.:.|||:.:....|.:::.::|      ||..|:.|  ...
  Fly   547 LESYYLFTTFRSWRMEWSFNKMRDLLMKYSLGMMVFAGATIIAMDLLVKSEAMDYTMLFSLFLLI 611

  Fly   611 VLPASVATIQCILALIAWYKKYCWTRYGRNNVPHHYNGF--SCFIFRIHDKILNSLPIRICIYLF 673
            :||          .|:|.||| .|.| ||...|.....|  |.:..:..|.|..|:.:||.:.:.
  Fly   612 LLP----------LLLASYKK-LWLR-GRRLSPITQPTFFLSRWFIKASDLIEKSVFVRIPLAIM 664

  Fly   674 LMISSFFVMCLIVMSCQREEFEMAYIEERLFHYEQEAHICFHPWVTTNMLSLMICLTFTFAHIPI 738
            ::...:.:....|.||.....|:..|...| |..:...:||.||..|..:.:::.|......||:
  Fly   665 VLFLLYVMSSETVFSCDIARLELEIINSEL-HNLRPQMLCFMPWGVTYAVVIVLSLMLVIIGIPL 728

  Fly   739 MVKTAVAILETLAYLLLIFFQFDFVFHHSVTTNPYFKSEYAHALLICITFLIMFVKERQIEFTNK 803
            ::|..|.:....::::.:...:.|.|..|.|||....|..||:..:...|:::.|:|..:.:..|
  Fly   729 IIKLGVGLAILGSHVITVHAYYGFAFERSQTTNIGVTSSLAHSWYMVAFFIVVVVREGYLNYILK 793

  Fly   804 VNFNWRVDLRKEENAASLTNHSIIIILNNILPSHIVDVYLNSLAKHELYFENYRMVSVMFAMLIN 868
            .::...:...|:.....:...:|.||:.||||:|:.:|:.......:||:||:..|:||||.:.|
  Fly   794 ASYFMSMCFEKKHELTKVKTRTIKIIMANILPTHVAEVFKVRRRSDQLYYENFSQVAVMFATIEN 858

  Fly   869 FEMDLRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGL------DLNFAGSTSTNR 927
            :|.|...||.|:|:|..||.||:.|:.:|.:||||::|.||:|||||      |.:.:...||||
  Fly   859 YEADKSGLRALHEMICYFDELLVNYQSWYKIEKIKVMGWTYLAACGLHVDHYTDFSVSVPISTNR 923

  Fly   928 KES---------IPPTEFNEEQSRRILFQQ--SNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSI 981
            :..         ..|.:.:|...:.:...|  :||| |..:.|||.:||:::|.|..........
  Fly   924 ESDKLQKSGSVRFAPMDGDEIMIKDLHPTQATTNED-DNTILVMTEFALNLLRILRDIRSKGIFF 987

  Fly   982 AGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEILQ 1046
            ..|..:| |::.|||:.|.||||:||.|:|||||||:.|||||||.|||:...|||||.|:.:|:
  Fly   988 EKDSKLT-GSLKIGIAHGPVMAGVVGLSKPHYDIWGHTVNMASRMTSTGVRDGIHVTESTANVLR 1051

  Fly  1047 QFGITCSYRGMTFVKGRGKIPTYLVGIDENLNFIPQKATRFPSHQERSTVISL 1099
            .|.|.|:|||||||||.|::|||||.:||||:| .|.:....||  :.:::|:
  Fly  1052 DFNIRCTYRGMTFVKGVGQVPTYLVDLDENLHF-QQHSPDNDSH--KGSIVSV 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	58/262 (22%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	86/168 (51%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	108/236 (46%)
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	83/156 (53%)
		CYCc	812..1051	CDD:214485	100/240 (42%)
		Nucleotidyl_cyc_III	841..1076	CDD:299850	108/236 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453912
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	1	1.000	-	-		FOG0007605
OrthoInspector	1	1.000	-	-		otm48748
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45627
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.940