Protein Alignment ACXE and Ac3

DIOPT Version :10

• Sequence 1: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Alignment Length: 1253
• Identity: 323/1253 - (25%)
• Similarity: 549/1253 - (43%)
• Gaps: 309/1253 - (24%)

  Fly    69 TIERRSIIYFDVALSIGCALVLILVLSVNFCDEFIAKHT---------WYMYASSIF-------- 116
            |..||.....|||..:|.....:::|..:..:|....::         |:::|:::|
  Fly    24 TTSRRRQNDSDVAGGVGITGGGVVILPQHVLNELYHNYSIKQRRSGLKWFVFAAALFNIWTIGIP 88

  Fly   117 -----------ASLTLVFADLTESIYHTYAHS--------------------WILGTFYDTYIIY 150
                       ..:.|.:..|| ::.|....|                    |:|...:.|..:.
  Fly    89 WDQSAPTRVINCCMLLAYLALT-ALLHIGRRSDKPALRRFHQILLIIVPRALWLLSILHFTVYVI 152

  Fly   151 MIYMFLPIHFISGAVLLALLV----------SGL---YILYFV-IFIAQGFAQFASALFSVGGMS 201
            :...|.|...:..|:||..||          .||   .|.||: :.:..|::.:.|.|.:  .::
  Fly   153 LQPSFSPRDLLGWAILLNFLVYVTLPLQLIFLGLSIGCITYFICLSLPVGYSHWDSLLSN--QLA 215

  Fly   202 VDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLDSILPPQISLPLQ 266
            .:.|......|:|:.|..|.:...:.:||:..:.::.|:.:.....::::||.|:||..:::.::
  Fly   216 ANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMR 280

  Fly   267 KDIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRF 331
            :|:         |..|..|.:: :.:..|.:|||||||:|.:|.:::|.:.:.|||:|::|:.||
  Fly   281 EDL---------GSSSSEAFKK-IYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARF 335

  Fly   332 DLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVILGLSMINHIMEVRDIHGLDINMRIGVH 396
            |..|.:|:..|||.|||||||::|..|..||||..||.:||||:..|..|:......::||:|:|
  Fly   336 DRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIH 400

  Fly   397 SGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVHISGATLNNLDVNRFDIEDGPEEARDH 461
            :|.:.||::|:.:.|||::..||.:||.:||:|..|.||||..||..|: ..|::|....|.|:.
  Fly   401 TGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLN-GEFEVEAAFGEKREE 464

  Fly   462 PLLKKYRIRSYIIRQ------------------------------DLHMDDEDSDEFLGD---LH 493
             ||:...:::|.|.:                              |:..|::|:|..|.|   |.
  Fly   465 -LLRIAGLKTYFITKVVKAFASPCAKKINETQAEIAHPNPNGSTTDIVSDEDDNDATLDDEELLA 528

  Fly   494 SISLCNMGAQPRISDSANQSLRAL---FHEELREEFRKMPVSAFSPKRLLGICRFNTGKEVPAHQ 555
            ..|:.| |.|..|:.:|::..:..   |.:.|::|.               :.|       ..|:
  Fly   529 QNSVSN-GHQIGIAVTADEEEQVKLENFKQRLKDEL---------------VTR-------DGHE 570

  Fly   556 NL----NICLTFTDPILERAYLKQTDYMYKYSI--ILSASVGCSLVYIELMDTQMICSSCFVLPA 614
            ||    ||.|.|.:|.||:.|   ..|...||.  :|:|      :.::.:|   :..|..|||.
  Fly   571 NLTKDTNIFLRFKNPQLEQLY---AVYREPYSSLPLLAA------LLVQCID---VLYSYLVLPR 623

  Fly   615 S-------VATIQCILALIAWYKKYCWTRYGRNNVPHHYNGFSCFIF-----RIHD----KILNS 663
            |       .|.:..|..|:.            .::...::|.....|     |.:|    :.|.:
  Fly   624 STLHFINIAAPLVPIAMLVV------------ISLAESFSGMLPKFFVDVSKRFNDITFVRELAA 676

  Fly   664 LPIRICIYLFLMISSFFVMCLIVMSCQREEFEMAYIEERLFH----YEQEAHICFHPWVTTNMLS 724
            :.|.:.|....:|..||.:..:     |.|.   .:.|..|:    .|.:.::.....||...|
  Fly   677 IIIALTIGFSNVIDMFFFVTFV-----RTEH---IVSESEFNVTASLESDINLVVEGMVTAEHL- 732

  Fly   725 LMICLTFTFAH-----IP--------------IMVKTAVAILETLAY-----LLL---------- 755
                |..:|..     :|              :::..|:|::..|.:     |||
  Fly   733 ----LPASFVEQMRDAVPTERVLYPSYLSNFGVLILIAIAVIAQLTHLTKILLLLSIAALHCYFN 793

  Fly   756 IFFQFDFV-----FHHSVTTNPYFKSEYAHALLICITFLIMFVKERQIEFTNKVNFNWRVDLRKE 815
            ||...|..     |.|    .|...:.||.:.|:.:..|.:....|.::..::|.|.|:.::.::
  Fly   794 IFIMQDLYALEDDFEH----QPIISTRYAASGLLLVAALALSTLARHMDHEDRVIFKWKTEVAEQ 854

  Fly   816 ENAASLTNHSIIIILNNILPSHIVDVYL-NSLAKH-ELYFENYRMVSVMFAMLINF--------- 869
            :..|:........::.|:||.|:.:.:: |:...| :||.::|..|.|:||.:.||
  Fly   855 KETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETV 919

  Fly   870 -EMDLRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPP 933
             ...|..||.|||:|::||.||.. .::..:.|||.:|.|||||.|:::.     .|.|.:: |.
  Fly   920 NNQGLECLRFLNEVISDFDALLEL-PQFQDIIKIKTIGSTYMAASGINVQ-----RTVRNDA-PI 977

  Fly   934 TEFNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISS 998
            ||           :.|:      :.::..:||::...|...||        ::.....:.:||:.
  Fly   978 TE-----------RWSH------LAILVEFALELKHALQSINE--------QSFNHFVLKMGINH 1017

  Fly   999 GEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEILQQFGITCSYRGMTFVKGR 1063
            |.:.||::||.:||||||||.||:||||||||..|.|.|||||..||:.||.|...||:..|||:
  Fly  1018 GPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGK 1082

  Fly  1064 GKIPT-YLVGIDEN-----------LNFIPQKATRFPSHQERSTV-----------ISLQSTYTH 1105
            |::.| ||.|..::           ||.....|....|..|.|.:           .||:.....
  Fly  1083 GQLMTFYLQGKSQSSAEPVASGVVVLNGQDSSAVESTSELEASDIKMPLLKMNGPEQSLEIDQDR 1147

  Fly  1106 AENNNSIASTSRHTLQSL 1123
            :..|:|....|....|||
  Fly  1148 SLRNDSAGQESVAECQSL 1165

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AcyC	65..453	CDD:441717	124/445 (28%)
		Nucleotidyl_cyc_III	290..459	CDD:448371	74/168 (44%)
		Nucleotidyl_cyc_III	851..1071	CDD:448371	86/230 (37%)
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	107/345 (31%)
		Guanylate_cyc	294..476	CDD:425528	78/183 (43%)
		Guanylate_cyc	892..1092	CDD:425528	87/231 (38%)