DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXE and ACXC

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster

Alignment Length:	1109	Identity:	566/1109 - (51%)
Similarity:	756/1109 - (68%)	Gaps:	26/1109 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RSLGNCQLNYSKERMWEPGYLKAKCAELRLESEFRLYRIRLWKSYLLTFFMLHIFVTSVHCALLL 67
            :.|..|.|:|:.||:||..||:.||.||.||.|:|.|::||..|.|..|::|.|.:......:.|
  Fly    16 KRLRPCHLDYANERLWEHSYLREKCKELNLEEEYRYYQVRLMVSNLTIFYVLFIILAMSFLTIEL 80

  Fly    68 ATIERRSIIYFDVALSIGCALVLILVLSVNFCDEFIAKHTWYMYASSIFASLTLVFADLTESIYH 132
            ..::..:.::|:..:.:...::::.|||:|||::|:::|.|.|.|||:.:...:|..|:....||
  Fly    81 LYVQHYNAVFFNFVIRVVSTILVLTVLSINFCEKFVSRHRWVMIASSVLSVYLVVLTDIVMISYH 145

  Fly   133 TYAHSWILGTFYDTYIIYMIYMFLPIHFISGAVLLALLVSGLYILYFVIFIAQGFAQFASALFSV 197
            .|.:.|.|.|.:|.:.:.||||||||..|.||.|||..||.:|:.:|:..:...........|..
  Fly   146 FYKNDWPLNTSFDVFTLCMIYMFLPIPSIKGAALLASSVSLIYVAFFMHSLTFNAVYTDRDSFGY 210

  Fly   198 GGMSVDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLDSILPPQIS 262
            ..:|.||:|.|..|::|||:|:||||:||:|||||||:|.|:.|||:|.|||..||||||||||:
  Fly   211 DVISTDILHNLGFNMMGIFFRIMNDTMVRASFLDRHQFIMEETWLRHALLQESILLDSILPPQIA 275

  Fly   263 LPLQKDIQGRIVMAKQGIHSWTAMERT----MAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKV 323
            .|:|:.|:.:|..::.....:....||    ||||||||||||||||||||||||||||..||||
  Fly   276 KPVQEKIKSKITQSENSPDRFQMGPRTTESFMAIQIHPDVSILYADVVNYTHLTTTLTVGNLVKV 340

  Fly   324 LHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVILGLSMINHIMEVRDIHGLD 388
            |||||||||:||..:||||||||||||||||||:.||||||..||.||:|||::|.|||...|||
  Fly   341 LHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGLD 405

  Fly   389 INMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVHISGATLNNLDVNRFDIED 453
            |:||||||||:|.||:||||||||||||.||.|||.|||||.||.||:||.||:.|:...:.|..
  Fly   406 IDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLNPADYTILS 470

  Fly   454 GPEEARDHPLLKKYRIRSYIIRQDLHMDDEDSDEFLGDLHSISLCNMGAQPRISDSANQSLRALF 518
            |.::|:..|:|:  .|.:|::...:..  |.....:|.:.|.|:..:.:..||..|  :..::..
  Fly   471 GTQKAQSDPVLQ--YIHTYLLTGQVAR--ESFITSIGGVRSSSVLEVKSIDRIRSS--RPSQSSM 529

  Fly   519 HEELREEFRKMPVSAFSPKRLLGIC----RFNTGKEVPAHQNLNICLTFTDPILERAYLKQTDYM 579
            .:|.|||||.|||...:   |...|    |.:|.|:......: .|..|.|..||..||.|.|::
  Fly   530 TDEFREEFRNMPVGGIN---LNSPCCRRTRLDTHKKTQREIGI-FCAAFKDSSLEWNYLHQPDFI 590

  Fly   580 YKYSIILSASVGCSLVYIELMDTQMICSSCFVLPASVATIQCILALIAWYKKYCWTRYGRNNVPH 644
            :|.|::|:..:||.|:||:::.....|::|.|:..........|..:||||..||.:.||... .
  Fly   591 FKSSMLLAWGIGCCLIYIQIVTNNFSCTACIVVDLVTFFFLTSLLCLAWYKNVCWWKSGRYEF-R 654

  Fly   645 HYNGFSCFIFRIHDKILNSLPIRICIYLFLMISSFFVMCLIVMSCQREEFEMAYIEERLFHYEQE 709
            .|..:||..|.|.:||.:|:.:||.:||.::.|.:.|:.||:::|.|:.:|::|||.:::|||.:
  Fly   655 IYGKYSCMAFHIFEKIQHSVSLRITVYLGILFSYYAVISLIMLNCDRDMYELSYIESKIYHYEMD 719

  Fly   710 AHICFHPWVTTNMLSLMICLTFTFAHIPIMVKTAVAILETLAYLLLIFFQFDFVFHHSVTTNPYF 774
            ...||||||.|||:||::.:::|||.||..:|..::..|||||||::||||.|:|.||.||.|:.
  Fly   720 RDTCFHPWVFTNMISLILGISYTFARIPFGLKIVISCCETLAYLLIVFFQFAFIFQHSATTTPFM 784

  Fly   775 KSEYAHALLICITFLIMFVKERQIEFTNKVNFNWRVDLRKEENAASLTNHSIIIILNNILPSHIV 839
            |:|.||.|.:|:..|.|:.||||.||..|:|:...|||:.::.||.|||.||||:||||||||:|
  Fly   785 KAELAHCLRVCMMLLTMYAKERQSEFNTKMNYKLNVDLQNKQKAADLTNQSIIILLNNILPSHVV 849

  Fly   840 DVYLNSLAKHELYFENYRMVSVMFAMLINFEMDLRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKI 904
            |:|||||||||||:||||||||||||||||.|:|.||||||:||.:||.||..|:|||.|||||:
  Fly   850 DLYLNSLAKHELYYENYRMVSVMFAMLINFPMNLPSLRVLNDIITQFDRLLTAYREYYVVEKIKV 914

  Fly   905 VGCTYMAACGLDLNFAGS---TSTNRKESIPPTEFNEEQSRRILFQQSNEDL--DEVVFVMTSYA 964
            ||||||||||||.|.|.:   |...|..|: ..|....::.|:..:..:.|:  |||||:||::|
  Fly   915 VGCTYMAACGLDFNLASNIRQTDHFRNSSL-HVEVEHARNHRMTDENYDSDMNNDEVVFIMTTFA 978

  Fly   965 LDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMEST 1029
            ||:|||||..|.||.|...:|:::.|.|.|||||||:|||:||||||||||||||||||||||||
  Fly   979 LDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMAGVVGASQPHYDIWGNPVNMASRMEST 1043

  Fly  1030 GLPGHIHVTEETSEILQQFGITCSYRGMTFVKGRGKIPTYLVGIDENLNFIPQKATRFPSHQERS 1094
            ||||||.||||:::|||:|.|.|.|||||||||||.||||.|||||||.|:..|... .|...|.
  Fly  1044 GLPGHIQVTEESAKILQEFDIKCIYRGMTFVKGRGDIPTYFVGIDENLKFMSAKLVN-RSLSRRF 1107

  Fly  1095 TVIS 1098
            :|:|
  Fly  1108 SVMS 1111

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	100/240 (42%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	126/168 (75%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	148/224 (66%)
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	106/251 (42%)
		CYCc	293..468	CDD:214485	126/174 (72%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	124/158 (78%)
		CYCc	833..1060	CDD:214485	152/227 (67%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	148/224 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449936
Domainoid	1	1.000	187	1.000	Domainoid score	I6943
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5228
OMA	1	1.010	-	-		QHG27505
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	1	1.000	-	-		FOG0007605
OrthoInspector	1	1.000	-	-		otm48748
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	10	9.810