DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXE and Ac13E

DIOPT Version :9

Sequence 1:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster

Alignment Length:	1649	Identity:	330/1649 - (20%)
Similarity:	545/1649 - (33%)	Gaps:	675/1649 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ERMWEPGYLKAKCAELRLESEFR---LYRIRLWKSYLLTFFMLHIFVTSVHCAL---LLATIERR 73
            ||.....:|..|.....||.:::   ...:|:...:.|::.:|        |:|   |...::..
  Fly    62 ERAAAKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFTLSYILL--------CSLMWCLYFVVDGG 118

  Fly    74 SIIYFDVALSIGCALVLILVLSVNFCDEFIAKHTWYMY-----ASSIFASLTLVFADLTESIYHT 133
            |..::....|....|.|:.::::.|..       |.:|     .:|...:|.|..|.|....|..
  Fly   119 SEDFWRPISSSFSMLSLVTIMALCFTH-------WDLYREHRTVTSAVTALLLCGASLAFLTYTG 176

  Fly   134 YAHSWILGTF-YDTYIIYMIYMFLPIHFISGA----------VLLALLVSGLYILYFVIFIAQGF 187
            .|.| .||.| ....|:.:||..||:....||          .:::.:|.|...::.......|.
  Fly   177 RAFS-PLGHFAICLEIVLLIYTALPMPLWLGASTAISYSIAFEMVSHMVIGCSAIHGGPMHGGGG 240

  Fly   188 AQFASALFSVGGMS-----VDIVHYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIWLRNARL 247
            |...|.:.:.|..|     :.|:.:|.::|||:...:||...:|.:|:.    :.:.:.:|....
  Fly   241 AAGGSGMEANGDPSNRILILRIMAHLSVHLVGVHVLIMNLVRMRGTFMK----VGQNLLVRRQLE 301

  Fly   248 QEKQL----LDSILPPQIS----------------LPLQKDIQGRIVMAKQGIHSWTAMERTMAI 292
            .||||    :.|::||:::                ||.:..     .|..:..:...::.|...:
  Fly   302 MEKQLKEKMIHSVMPPKVADMLLNEGGPSGLDAGGLPPESH-----YMRPRASNDVKSLFRPFHM 361

  Fly   293 QIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLS 357
            ....:||||:||:|.:|.:::|.|.|.||::|:||:.|||........::|..||||||||:|..
  Fly   362 HSMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCP 426

  Fly   358 DPDPDHANNCVILGLSMINHIMEVRDIHGLD-INMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTI 421
            :|..|||..||.:||.||: .|...|....: :.||:|||:|.:..|::|..:::||:|..||::
  Fly   427 EPRADHAICCVEMGLGMID-AMRCFDAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSL 490

  Fly   422 ANVLESTGVPGCVHISGATLNNLDVNRFDIEDGPEEARDHPLLKKYRIRSYII---RQD------ 477
            ||.:||:|.|..||||..|.:.|. :.:.:|:| ||...|        |:|.:   |:|
  Fly   491 ANKMESSGKPEQVHISQETSSFLG-DAYYLEEG-EEVFGH--------RTYFVVGRRRDFTRTNS 545

  Fly   478 ----LHMDDEDSDEFLGDLHSISL----CNMGA-QP---------RISDSANQSLRALFHEELRE 524
                :..:...|...|...|..||    .|:.| ||         ::|.|.|.|........|..
  Fly   546 LSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNPSPVLSMRPRLTS 610

  Fly   525 EFRKM-----------------PVSAFSP---------------KRLLG---------------- 541
            ...||                 |.:|..|               |.|.|
  Fly   611 LSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPKIIITTKSLPGSLDSDEQPPVSPPLLP 675

  Fly   542 -------------------ICRF-----------------NTG--------------KEVPAHQN 556
                               |.||                 :.|              :|:..|..
  Fly   676 PANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGSSSAGHLDKEREREREKEKEELHQHNQ 740

  Fly   557 LN--ICLTFTD---------------------------------PILERAYLKQTDYMYKYSIIL 586
            ||  ..|.|.|                                 |:|..|   .|......|::.
  Fly   741 LNPEETLAFMDNQMQNGNGCGYQQLPVLVESNHRTQTLDIPAARPVLHHA---ATSTALASSVLR 802

  Fly   587 SASVG-------CS----LVYIELMDTQ------------------------------------- 603
            |...|       ||    .:|.:::|.:
  Fly   803 SPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRSDISPFGRSGSYRSQCGRQSTGGVNGAGPA 867

  Fly   604 ----------------------------------------------------------------- 603

  Fly   868 GVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTPNSLEPGPSSTSPCCLPAPGNSVGGGGIF 932

  Fly   604 --------MICSSC--------------------------------------------------- 609
                    .||.|.
  Fly   933 PPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIYALNQTAISQHRVSGYFTSSTSSISNLGEV 997

  Fly   610 --------------FVLPA--------------------SVATIQCI---------------LAL 625
                          .::||                    .:..|:|:               |..
  Fly   998 QGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPPLRK 1062

  Fly   626 IAWYKKYCWT---------RYGRNN---------VPHHYNGFSCFIFRIHDKILNSLPIRICI-- 670
            .:.|.|....         |:|..|         .|.:......|:         .:.:.:||
  Fly  1063 FSLYFKSRQLERDFRSKAHRFGAENETEGPPTLATPRYNTYIDIFV---------GIAVYLCISV 1118

  Fly   671 YLFLM----ISSFFVMCLIVMSC---------------------------------------QRE 692
            .||||    :|..|.:.:.:.||                                       :|:
  Fly  1119 SLFLMTQNTVSPSFRLWVTLFSCFTGIQVFALFLFTRQMCRRQSGSNVSNRFRSKSTTSEDLERD 1183

  Fly   693 E----------FEMAYIEERLFHYEQEAHICFHPW--------------VTTNMLSL-------- 725
            |          ||..  .:|:|    ||...::||              :..|.|.|
  Fly  1184 ERGAAPGGRPHFESC--ADRIF----EAISSWYPWHICLAVLMAMPVLLIIANFLLLDLEQLEAF 1242

  Fly   726 --------MICLTF--TFAHIPIMVKTAVAILETLAYLLLIFFQFDFVFHHSVTT---------- 770
                    .:|:..  .|..:...|:..:|.|..|.::.:...|. .|:.|:.:.
  Fly  1243 EYHYGFLIFVCIVHFCNFTQLNCWVRNVLAFLAALCFIGIAVSQL-MVYSHNRSDQQQDQEASNF 1306

  Fly   771 -------NPYFKSEYAHALLICITFLIMFVKERQIEFTNKVNFNWRVDLRKEENAASLTNHSIII 828
                   ..|....|...|||.:  |:.|: .|:.|...::.|.......:::.......:...:
  Fly  1307 IQEIKWFQDYHVEIYLDLLLILV--LVWFL-NREFEIGYRLTFYGNAVANQDKVRVQNMKNQADM 1368

  Fly   829 ILNNILPSHIVDVYLNSLAKHELYFENYRMVSVMFAMLINF-EMDLRS-------LRVLNEIIAE 885
            :|:||:|.|:.: :|.:.||   |.||:..::::||.::|| ||...|       ||||||:|.:
  Fly  1369 LLHNIIPKHVAE-HLKNTAK---YSENHHNIAIIFASIVNFNEMYDESYLGGKEFLRVLNELIGD 1429

  Fly   886 FDTLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSN 950
            ||. ||...|:..|||||.:|.|:|||.|||.:..|:.
  Fly  1430 FDE-LLSRPEFRAVEKIKTIGSTFMAASGLDPSHRGTG--------------------------- 1466

  Fly   951 EDLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDI 1015
               ||.:..:..:::.|...:    :|:.....:.|:   .:.||::.|:|.||::|.|:.:|||
  Fly  1467 ---DEHIHTLMEFSIAMQEVV----DAFNKDLLEFNL---ILRIGMNIGDVTAGVIGTSKLYYDI 1521

  Fly  1016 WGNPVNMASRMESTGLPGHIHVTEETSEILQQFGITCSY----RGMTFVKGRGKIPTYLVGI--- 1073
            ||:.||:||||:|||||..|.|.::....|     |..|    ||..:|||:..:..:|...
  Fly  1522 WGDAVNVASRMDSTGLPNRIQVGKDCLPFL-----TNRYEFEPRGSVYVKGKDHMEVFLYTTRRD 1581

  Fly  1074 ----DENLNFIPQKATRFPSHQER 1093
                |:..:.:.|..|:...|:.|
  Fly  1582 NPLDDDEADKVEQLGTKKMEHEGR 1605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	59/287 (21%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	70/169 (41%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	75/231 (32%)
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	77/222 (35%)
		Guanylate_cyc	361..535	CDD:278633	73/184 (40%)
		CYCc	1362..1556	CDD:214485	77/240 (32%)
		Guanylate_cyc	1388..1575	CDD:278633	75/229 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453973
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840